Creon 10,000 capsules 20 pcs
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Active ingredients
Pancreatin
Release form
Capsules
Composition
Active ingredient: Pancreatin (Pancreatin) Active ingredient concentration (mg): 150
Pharmacological effect
Enzyme agent. Contains pancreatic enzymes - amylase, lipase and proteases, which facilitate the digestion of carbohydrates, fats and proteins, which contributes to their more complete absorption in the small intestine. In diseases of the pancreas, it compensates for the insufficiency of its exocrine function and contributes to the improvement of the digestive process.
Pharmacokinetics
The pharmacokinetics of pancreatin has not been studied.
Indications
Cystic fibrosis, chronic pancreatitis, after surgery on the pancreas, after gastrectomy, pancreatic cancer, partial resection of the stomach (eg, Billroth II), obstruction of the pancreatic ducts or common bile duct (eg, due to neoplasm), Shvakhman-Diamond syndrome.
Contraindications
Hypersensitivity to pancreatin of porcine origin or to one of excipients, acute pancreatitis, exacerbation of chronic pancreatitis.
Precautionary measures
Do not exceed recommended doses.
Use during pregnancy and lactation
The safety of using pancreatin during pregnancy has not been studied enough. Use is possible in cases where the expected benefit to the mother outweighs the potential risk to the fetus. In experimental studies, it was found that pancreatin does not have a teratogenic effect.
Dosage and administration
Inside. Doses of the drug are selected individually depending on the severity of the disease and the composition of the diet. Capsules should be taken during or immediately after each meal (including snacks), swallowed whole, not broken and not chewed, drinking plenty of liquids. For difficulty swallowing (for example, in young children or elderly patients), the capsules are gently opened, and minimicrospheres are added to liquid foods that do not require chewing and have a sour taste, for example, apple sauce or fruit juice. ku (pH <5.5). It is not recommended to add the contents of the capsules to hot food. Any mixture of minimicrospheres with food or liquid cannot be stored, and should be taken immediately after preparation. It is important to ensure that the patient receives sufficient fluid at all times, especially with increased fluid loss. Inadequate fluid intake can lead to or increase constipation.
Side effects
Nausea, vomiting, constipation and bloating, diarrhea, itching, urticaria, allergic reactions.
Overdose
No cases of drug overdose have been reported.
Interaction with other drugs
With simultaneous use with antacids containing calcium carbonate and / or magnesium hydroxide, it is possible to decrease the effectiveness of pancreatin. With simultaneous use, it is theoretically possible to reduce the clinical efficacy of acarbose.
special instructions
It is not recommended to use in the acute phase of chronic pancreatitis. In cystic fibrosis, the dose should be adequate to the amount of enzymes that are necessary for fat absorption, taking into account the quality and quantity of food consumed. lipase) due to an increased risk of stricture development (fibrous colonopathy) in the ileo-cecal and in the ascending colon. With a high activity of the lipase contained in pancreatin, the likelihood of nce of constipation in children. Increasing the dose of pancreatin in this category of patients should be carried out gradually. Violations of the digestive system can occur in patients with hypersensitivity to pancreatin, or in patients with meconium ileus or bowel resection in history.