CYTOFLAVIN ampoules 10 ml 10 pcs
Condition: New product
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Active ingredients
Inosine + Nicotinamide + Riboflavin + Succinic Acid
Release form
Ampoules
Composition
Active ingredient: Inosine + Nicotinamide + Riboflavin + Succinic Acid (Inosinum + Nicotinamidum + Riboflavinum + Acidum succinicum) Active ingredient concentration: Succinic Acid 100 mg, inosine (Riboxin) 20 mg, Nicotinamide 10 mg, Riboflavin mononucleotide (Riboflavin)
Pharmacological effect
Metabolic drug. Pharmacological effects are due to the complex effect of the components contained in the preparation Cytoflavin. Stimulates the processes of cellular respiration and energy production, improves oxygen utilization by tissues, restores the activity of enzymes that provide antioxidant action. The drug activates intracellular protein synthesis, promotes glucose utilization, fatty acids and GABA resynthesis in neurons through Roberts shunt. It has a positive effect on the bioelectric activity of the brain . Tsitoflavin improves cerebral and coronary blood flow, activates metabolic processes in the central nervous system, reduces reflex disorders eniya, the recovery of impaired sensitivity and intellectual-mental functions mozga.Polozhitelno affects the neurological status parameters: reduces the severity of asthenic, cephalgic, vestibular-cerebellar, cochleovestibular syndrome, and eliminates disorders of emotional and volitional (reduces anxiety, depression). It improves cognitive-mnestic functions and quality of life. When administered, it helps to restore impaired consciousness. It has a quick awakening effect in post-anesthetic depression of consciousness. When using Cytoflavin in the first 12 hours from the onset of stroke, there is a favorable course of ischemic and necrotic processes in the affected area (reduction of the focus), restoration of neurological status and a decrease in the level of disability in the long-term period.
Pharmacokinetics
With intravenous infusion at a rate of about 2 ml / min (in terms of undiluted cytoflavin), succinic acid and inosine are utilized almost instantly and are not detected in the blood plasma. Inosine is metabolized in the liver to form hypoxanthine and subsequent oxidation to uric acid.In small amounts excreted by the kidneys. Nicotinamide is rapidly distributed in all tissues, penetrates the placental barrier, is excreted in breast milk. Metabolized in the liver with the formation of nicotinamide-N-methylnicotinamide, excreted by the kidneys. T1 / 2 of plasma is about 1.3 h, Vss is about 60 l, total clearance is about 0.6 l / min. Riboflavin is unevenly distributed: the largest amount is in the myocardium, liver, and kidneys. T1 / 2 of plasma is about 2 h, Vss is about 40 liters, total clearance is about 0.3 l / min. Gets through a placental barrier, it is allocated with breast milk. Plasma protein binding - 60%. Excreted by the kidneys, partly as a metabolite; when used in high doses, mostly unchanged.
Indications
Solution for intravenous administrationIn the composition of complex therapy in adults: - acute cerebrovascular accident; - dyscirculatory (vascular) encephalopathy stage 1-2 and the consequences of cerebral circulation disorder (chronic brain ischemia); - toxic and hypoxic encephalopathy in acute and chronic poisoning, endotoxicosis, depression of consciousness after anesthesia.
Contraindications
Lactation; hypersensitivity to the drug components. Patients on mechanical ventilation are not recommended to prescribe Cytoflavin when the partial pressure of oxygen in arterial blood is lower than 60 mm Hg.
Precautionary measures
In the formation of sediment use of the drug is prohibited.
Use during pregnancy and lactation
If necessary, you can use the drug inside during pregnancy and lactation (breastfeeding) in the absence of allergic reactions to the components of the drug.In / in the introduction of the drug during pregnancy is allowed, during lactation (breastfeeding) - is contraindicated.
Dosage and administration
The solution for IV injection Tsitoflavin is administered only intravenously in a drip dilution per 100-200 ml of 5-10% glucose solution, 0.9% sodium chloride solution. In acute cerebral circulation disorders, the drug is administered as early as possible from the onset of the disease in the amount of 10 ml per injection with an interval of 8-12 hours for 10 days. In a severe form of the disease, a single dose is increased to 20 ml. In case of dyscirculatory encephalopathy and the consequences of cerebral circulation disorders, Cytoflavin is administered in a dose of 10 ml of solution for 1 administration 1 time / day for 10 days. In toxic and hypoxic encephalopathy, the drug is administered in a dose of 10 ml solution for 1 introduction 2 times / day after 8-12 hours for 5 days.In a comatose state, the drug is administered in a volume of 20 ml for administration at a dilution of 200 ml of glucose solution. When depression of consciousness after anesthesia, the drug is administered once in the same doses.
Side effects
With the rapid on / in the drip: possible hyperemia of the skin of varying severity, feeling of heat, bitterness and dry mouth, sore throat. These adverse reactions do not require discontinuation of the drug. With long-term intake in high doses: transient hypoglycemia, hyperuricemia, exacerbation of gout are possible. On the digestive system: intravenous administration rarely - short-term pain and discomfort in the epigastric region, nausea. On the part of the respiratory system : with intravenous drip infusion rarely - short-term pain and discomfort in the chest, difficulty breathing, tingling sensation in the nose. On the CNS side: when ingested, transient headache is possible; with intravenous drip infusion rarely - headache, dizziness. Allergic reactions: itching is possible. Other: with intravenous drip infusion rarely - dysosmia, blanching of the skin of varying severity.
Overdose
Symptoms of an overdose of the drug Tsitoflavin not detected.
Interaction with other drugs
Succinic acid, inosine and nicotinamide (active ingredients of the drug Cytoflavin) are compatible with other drugs. Cytoflavin is compatible with hematopoietic stimulants, antioxidants and anabolic steroids. With simultaneous use of Cytoflavin, it should be noted that riboflavin reduces the activity of doxycycline, tetracycline, tetracycline, tetracycline, tetracycline, tetracycline, tetracycline reduces tetracycline, tetracycline. oxytetracycline, erythromycin and lincomycin; incompatible with streptomycin effects of chloramphenicol (disorders of hematopoiesis, optic neuritis).
special instructions
In critical conditions, intravenous administration of the drug is possible after normalization of central hemodynamics. During the period of treatment, plasma glucose levels should be monitored. Against the background of drug administration, urine stains in a light yellow color. Effects on the ability to drive vehicles and control mechanisms the drug does not affect the ability to concentrate.