More info
Active ingredients
Econazole
Release form
Cream
Composition
Econazole nitrate 10 mg Auxiliary substances: sodium hydroxide - 0.9 mg, sodium dihydrogen phosphate dihydrate - 3.65 mg, phosphoric acid - 0.02 mg, chlorocresol - 1 mg, cetomacrogol 1000 - 50 mg, cetostearyl alcohol (cetyl alcohol 60%, stearyl alcohol 40%) 70 mg, white soft paraffin - 150 mg, liquid paraffin - 60 mg, purified water - sc. required up to 1 year
Pharmacological effect
Econazole is an imidazole derivative, a broad-spectrum antifungal drug for local use. It has a fungicidal and bactericidal effect. It inhibits the synthesis of ergosterol, which regulates the permeability of the cell wall of microorganisms. Active in the field of dermatophyxia. , Aspergillus, Cladosporium, Scopulariopsis brevicautus and some gram-positive bacteria (streptococci, staphylococci and Nocardia minutissima). Effective against fungi resistant to treatment with other drugs. When applied topically causes the death of fungi within 3 days, contributes to the rapid regression of burning and itching of the skin.
Pharmacokinetics
When applied externally, the drug penetrates all layers of the skin and the nail plate. Therapeutic concentrations are created in the stratum corneum and other layers of the epidermis, as well as in the dermis. When applied to the skin, systemic absorption is minimal and practically insignificant. Less than 1% of the applied dose is excreted with feces - the intestines, and kidneys.
Indications
- dermatomycosis of the scalp caused by dermatophytes, yeasts, mold fungi, incl. complicated by superinfection with gram-positive bacteria; - erythrasma; - versicolor versicolor; - skin infections caused by gram-positive microorganisms.
Contraindications
- Hypersensitivity to econazole and other components that make up the drug; - Children under 18 years of age. Do not apply the drug on areas with damaged skin.
Use during pregnancy and lactation
During pregnancy (I-II trimester) is used only if the intended benefit to the mother outweighs the potential risk to the fetus. When prescribing the drug during lactation, breastfeeding should be stopped.
Dosage and administration
Outside. Adults and children over 18: apply a thin even layer of cream on the affected area and rub until completely absorbed 2 times a day (morning and evening). Duration of application is 2 weeks, in the treatment of highly keratinized skin areas (feet) - up to 1 ,5 months.
Side effects
Individual intolerance to econazole and other components that make up the drug. Local reactions are possible in the form of burning, itching, irritation and redness of the skin, urticaria, dryness, hypopigmentation, skin atrophy.
Overdose
In case of accidental ingestion of the cream, nausea, vomiting, diarrhea are possible. Treatment: gastric lavage, ingestion of activated charcoal, and symptomatic therapy.
Interaction with other drugs
No data available.
special instructions
In patients with eczema, before starting treatment, anti-eczema therapy should be carried out. In the absence of the effect of therapy in the recommended time frame, it is necessary to verify the diagnosis. When the first symptoms of hypersensitivity appear, the drug should be canceled. Avoid contact of the drug with eyes, mucous membranes, open wounds. If any of the side effects develop when using the drug, its further use should be discontinued and consult a doctor. Information on the possible effect of the medicinal product for medical use on the ability to drive vehicles and mechanisms The drug does not affect the ability to drive vehicles and engage in other potentially dangerous species activities requiring increased concentration of attention and speed of psychomotor reactions.