Buy Essentiale Forte N Capsules 300mg N100

Essentiale Forte N Capsules 300mg N100

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Active ingredients


Release form



1 capsule contains: Active substance: phospholipids from soybeans containing 76% (3-sn-phosphatidyl) choline (synonyms - essential phospholipids, EPL) 300 mg; Auxiliary substances: solid fat - 57.000 mg, soybean oil - 36.000 mg, hydrogenated castor oil - 1.600 mg, 96% ethanol - 8.100 mg, ethyl vanillin - 1.500 mg, 4-methoxyacetophenone - 0.800 mg, α-tocopherol - 0.750 mg.; Capsule composition: gelatin - 67.945 mg, purified water - 11.495 mg, titanium dioxide ( E171) - 0.830 mg, iron dye yellow oxide (E172) - 2.075 mg, iron dye black oxide (E172) - 0.332 mg, iron dye oxide red (E172) - 0.198 mg of sodium lauryl sulfate - 0.125 mg.

Pharmacological effect

Essential phospholipids are the main elements of the structure of the membrane of cells and cell organelles. In liver diseases there is always damage to the membranes of the liver cells and their organelles, which leads to impaired activity of the associated enzymes and receptor systems, deterioration of the functional activity of the liver cells and reduced ability to regenerate.; Phospholipids that are part of the drug Essentiale; Forte H, correspond in their chemical structure to endogenous phospholipids, but surpass endogenous phospholipids in activity due to the higher content of polyunsaturated (essential) fatty acids in them. Embedding these high-energy molecules in the damaged parts of the cell membranes of hepatocytes restores the integrity of the liver cells and contributes to their regeneration. Cis-double bonds of their polyunsaturated fatty acids prevent parallel arrangement of hydrocarbon chains in cell membrane phospholipids, the phospholipid structure of cell membranes of hepatocytes is loosened, which increases their fluidity and elasticity, improves metabolism. The resulting functional blocks increase the activity of enzymes fixed on the membranes and contribute to the normal, physiological pathway of the most important metabolic processes.; Phospholipids, which are part of the preparation Essentiale; forte, regulate lipoprotein metabolism, transferring neutral fats and cholesterol to oxidation sites, this is mainly due to the increased ability of high-density lipoproteins to bind to cholesterol.; Thus, the drug has a normalizing effect on lipid and protein metabolism, detoxification function of the liver, to restore and preservation of the cellular structure of the liver and phospholipid-dependent enzyme systems,which ultimately prevents the formation of connective tissue in the liver and contributes to the natural restoration of liver cells.; With the excretion of phospholipids in the bile, a decrease in the lithogenic index and stabilization of bile occur.


Absorption, distribution, metabolism; More than 90% of ingested phospholipids are absorbed in the small intestine. Most of them are cleaved by phospholipase A to 1-acyl-lysophosphatidylcholine, 50% of which is immediately subjected to reverse acetylation in polyunsaturated phosphatidylcholine during the process of absorption in the intestinal mucosa. This polyunsaturated phosphatidylcholine with lymph flow enters the blood and from there, mainly in a high-density form associated with lipoprotenes, enters the liver. The pharmacokinetics studies in humans were carried out using radioactively labeled dilinoleyl (3H and 14C). The choline portion was labeled with 3H, and the linoleic acid residue had 14C as a label. Cmax 3H is reached 6-24 hours after administration and amounts to 19.9% ​​of the prescribed dose. T1 / 2 of the choline component is 66 hours; Cmax14C is reached after 4 -12 hours after administration and amounts to 27.9% of the prescribed dose. T1 / 2 of this component is 32 hours; Both isotopes are more than 90% absorbed in the intestine.; Excretion; In the feces, 2% of the administered dose of 3H and 4.5% of the administered dose of 14C are detected, in urine - 6% of 3H and only the minimum amount is 14C.


- chronic hepatitis; - cirrhosis of the liver; - fatty degeneration of the liver of various etiologies; - toxic liver damage; - alcoholic hepatitis; - abnormal liver function in other somatic diseases; - pregnancy toxicosis; - prevention of recurrence of gallstone formation; - psoriasis (as a means of adjuvant therapy); - radiation syndrome.


- children's age up to 12 years (lack of sufficient evidence); - known hypersensitivity to phosphatidylcholine or other auxiliary ingredients of the drug.

Use during pregnancy and lactation

Perhaps the use of the drug during pregnancy according to indications

Dosage and administration

Inside Capsules should be swallowed whole, drinking plenty of water (approximately 1 cup) .; For adolescents over 12 years old and weighing more than 43 kg, and also for adults Essentiale; Forte H is recommended to take 2 capsules 3 times / day with meals. As a rule, the duration of use is not limited.

Side effects

Essentiale forte N is usually well tolerated.; For evaluation purposes, the following definitions are used: very often (more than 1/10), often (more than 1/100-less than 1/10), infrequently (more than 1/1000-less than 1/100); rarely (more than 1/10 000-less than 1/1000), very rarely (less than 1/10 000), unknown; frequency (according to the available data it is impossible to establish the frequency; occurrence) .; On the part of the digestive system: perhaps -; feeling of discomfort in the stomach, mild stools, diarrhea.; Allergic; reactions: in very rare cases, skin allergies are possible; reactions (rash, exanthema , Urticaria, pruritus).


Currently, no cases of overdose have been reported.

Interaction with other drugs

Drug interaction of the drug is not described.