Furamag capsules 25mg N30 Latvia
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Active ingredients
Furazidin
Composition
1 caps Furazidin potassium 25 mg, which corresponds to the content of furazidina 21.85 mg. Excipients: potassium carbonate - 6.
Pharmacological effect
Antimicrobial agent of broad-spectrum, belonging to the group of nitrofurans. Furamagu resistance develops slowly and does not reach a high degree. Active against gram-positive cocci: Streptococcus spp., Staphylococcus spp .; Gram-negative bacilli: Escherichia coli, Salmonella spp., Shigella spp., Proteus mirabilis, Klebsiella spp., Enterobacter spp .; protozoa: Lamblia intestinalis and other microorganisms resistant to antibiotics. With respect to Staphylococcus spp., Escherichia coli, Aerobacter aerogenes, Bacterium citrovorum, Proteus mirabilis, Proteus morganii Furamag, is more active than other nitrofurans. Furamag exhibits higher activity for Enterococcus faecalis, Staphylococcus spp. compared with other groups of antibacterial drugs. Against most bacteria, the bacteriostatic concentration ranges from 1: 100,000 to 1: 200,000. The bactericidal concentration is about 2 times greater. Under the influence of nitrofurans in microorganisms, the respiratory chain and the tricarboxylic acid cycle (Krebs cycle) are suppressed, and other biochemical processes of microorganisms are inhibited, resulting in the destruction of their membrane or cytoplasmic membrane. As a result of the action of nitrofurans, microorganisms secrete less toxins, and therefore the improvement of the patient’s general condition is possible even before the pronounced suppression of the growth of microflora. Nitrofurans, unlike many other antimicrobial agents, not only do not inhibit the body's immune system, but rather activate it: they increase the complement titer and the ability of leukocytes to phagocytose microorganisms. At therapeutic doses, nitrofurans stimulate leukopoiesis.
Pharmacokinetics
Absorption After taking the drug inside, furazidin is absorbed in the small intestine by passive diffusion. The absorption of nitrofurans from the distal segment of the small intestine exceeds the absorption from the proximal and medial segments by 2 and 4 times, respectively (should be considered when simultaneously treating urogenital infections and diseases of the gastrointestinal tract, in particular chronic enteritis). Nitrofurans are poorly absorbed from the colon. Cmax in the blood plasma lasts from 3 to 7 or 8 hours, furazidin is detected in urine after 3-4 hours.Being a mixture of potassium salt of furazidine and magnesium carbonate basic in the ratio of 1: 1, oral administration of furamag has a higher bioavailability than simple furazidin (after taking the furamag capsule in an acidic stomach, the conversion of furazidine potassium does not occur in poorly soluble furazidin). Distribution In the body, furazidine is distributed evenly. It is clinically important to have a high content of the active substance in the lymph (delaying the spread of infection through the lymphatic ducts). In bile, its concentration is several times higher than in serum, and in cerebrospinal fluid - several times lower than in serum. In saliva, the content of furazidine is 30% of its concentration in serum. The concentration of furazidine in the blood and tissues is relatively small, which is associated with its rapid release, while the concentration in the urine is much higher than in the blood. Metabolism Slightly biotransformed (less than 10%). Withdrawal Unlike nitrofurantoin (furadonin), after taking Furamag, the urine pH does not change. 4 hours after taking the drug, the concentration of furazidine in the urine significantly exceeds the concentration that is formed after taking the same dose of furagin. Excreted by the kidneys by glomerular filtration and tubular secretion (85%), partially undergoes reverse reabsorption in the tubules. At low concentrations of furazidine in the urine, filtration and secretion predominate, at high concentrations, secretion decreases and reabsorption increases. Furazidin, being a weak acid, does not dissociate in acidic urine, undergoes intensive reabsorption, which may enhance the development of systemic side effects. When alkaline urine excretion of furazidina increases. Pharmacokinetics in special clinical situations With a decrease in renal excretory function, the intensity of metabolism increases.
Indications
Infections caused by microorganisms sensitive to furazidine: - urogenital infections (acute cystitis, urethritis, pyelonephritis) - gynecological infections - infections of the skin and soft tissues - severe infected burns - with prophylactic purposes for urological operations (including cystoscopy, catheterization).
Contraindications
- severe chronic renal failure - pregnancy - lactation period (breastfeeding) - children's age up to 3 years (for this dosage form) - hypersensitivity to nitrofuran preparations. The drug is used with caution when glucose-6-phosphate dehydrogenase is deficient.
Use during pregnancy and lactation
The drug is contraindicated during pregnancy and lactation (breastfeeding).
Dosage and administration
The drug should be taken orally after a meal, drinking plenty of fluids. Adults appoint 50-100 mg 3 times / day. Children are prescribed 25-50 mg 3 times / day (but not more than 5 mg / kg body weight per day). The course of treatment is 7-10 days. If necessary, repeat the course of treatment should be a break for 10-15 days. For the prevention of infection during urological operations, cystoscopy, catheterization, etc. the drug is prescribed to adults on 50 mg, for children - on 25 mg once for 30 minutes before the procedure. In case of skipping the drug, the next dose should be taken at the usual time. Do not take double the dose to compensate for the missed dose.
Side effects
On the part of the digestive system: rarely - nausea, vomiting, loss of appetite, abnormal liver function. From the side of the central nervous system and peripheral nervous system: rarely - headache, dizziness, polyneuritis. Allergic reactions: rarely - skin rash (including papular rash). Furamag low toxicity.
Overdose
Symptoms: manifestations of a neurotoxic nature, ataxia, tremor. Treatment: should drink plenty of fluids. For the relief of acute symptoms used antihistamines. For the prevention of neuritis it is possible to prescribe vitamins (thiamine bromide).
Interaction with other drugs
Furamag should not be used simultaneously with ristomycin, chloramphenicol, sulfonamides (the risk of hematopoiesis is increased). It is not recommended to prescribe drugs that can acidify urine (including ascorbic acid, calcium chloride) simultaneously with nitrofurans.
special instructions
To reduce the likelihood of side effects Furamag drink down with plenty of liquid. With the appearance of side effects, the use of the drug should be discontinued (toxic effects are more common in patients with reduced renal excretory function). The patient should inform the doctor about any side effects that occur during treatment with the drug. During the period of treatment, the patient is advised to refrain from the use of alcoholic beverages, since there may be an increase in side effects.Influence on ability to drive motor transport and control mechanisms Influence on ability to drive motor transport and control mechanisms is not noted.