Hemomycin pores for cook. suspension 100mg 5ml 20ml
Condition: New product
1000 Items
Rating:
Be the first to write a review!
More info
Active ingredients
Azithromycin
Release form
Powder
Composition
In 5 ml of the finished suspension contains: Azithromycin dihydrate 104.809 mg, which corresponds to the content of azithromycin 100 mg Auxiliary substances: xanthan gum - 20.846 mg, sodium saccharinate - 4.134 mg, calcium carbonate - 162.503 mg, anhydrous silicon dioxide - 26.008 mg, sodium phosphate anhydrous - 17.259 mg mg, sorbitol - 2145.682 mg, apple flavoring - 3.303 mg, strawberry flavoring - 8.159 mg, cherry flavoring - 12.096 mg.
Pharmacological effect
Broad-spectrum antibiotic. Azithromycin is a representative of the macrolide antibiotic subgroup - azalides. It has a bactericidal effect in high concentrations. Hemomycin is active against aerobic gram-positive bacteria: Streptococcus pneumoniae, Streptococcus pyogenes, Streptococcus agalactiae, Streptococcus spp. groups C, F and G, Streptococcus viridans, Staphylococcus aureus; Aerobic Gram-negative bacteria: Haemophilus influenzae, Moraxella catarrhalis, Bordetella pertussis, Bordetella parapertussis, Legionella pneumophila, Haemophilus ducreyi, Helicobacter pylori, Campylobacter jejuni, Neisseria gonor rh o rr o syrhacrus, pylori pylori, neyseroslae neyserophylus pylori, Helicobacter pylori Anaerobic Bacterium
Pharmacokinetics
Asythromycin is rapidly absorbed from the gastrointestinal tract, due to its stability in an acidic environment and lipophilicity. After ingestion of Hemomycin in the dose of 500 mg of azithromycin Cmax in the blood plasma is achieved in 2.5-2.96 hours and is 0.4 mg / l. Bioavailability is 37%. DistributionAzithromycin penetrates well into the respiratory tract, organs and tissues of the urogenital tract, into the prostate gland, into the skin and soft tissues. High tissue concentrations (10–50 times higher than in plasma) and prolonged T1 / 2 are due to the low binding of azithromycin to plasma proteins, as well as its ability to penetrate into eukaryotic cells and concentrate in a low pH environment surrounding the lysosomes. This, in turn, determines a large apparent Vd (31.1 l / kg) and high plasma clearance. The ability of azithromycin to accumulate primarily in lysosomes is especially important for the elimination of intracellular pathogens. It has been proven that phagocytes deliver azithromycin to the site of infection, where it is released during phagocytosis. The concentration of azithromycin in the foci of infection is significantly higher than in healthy tissues (by an average of 24–34%) and correlates with the degree of inflammatory edema.Despite the high concentration in phagocytes, azithromycin does not significantly affect their function. Azithromycin remains in bactericidal concentrations in the inflammatory focus for 5-7 days after the last dose, which allowed developing short (3-day and 5-day) courses of treatment Metabolism In the liver, azithromycin is demethylated, the metabolites formed are inactive. Excretion Azithromycin is removed from blood plasma in 2 stages: T1 / 2 is 14-20 hours in the interval from 8 to 24 hours after taking the drug and 41 hours in the interval from 24 to 72 h, which allows you to use the drug 1 time / day.
Indications
Infectious and inflammatory diseases caused by microorganisms that are susceptible to the drug: - infections of the upper respiratory tract and ENT organs (tonsillitis, sinusitis, tonsillitis, otitis media), scarlet fever, lower infections of the respiratory tract (bacterial, including atypical pathogens, pneumonia, bronchitis); - infections of the urogenital tract (uncomplicated urethritis and / or cervicitis); - infections of the skin and soft tissues (erysipelas, impetigo, secondarily infected dermatosis); - Lyme disease (borreliosis) for the treatment of the initial stage (erythema migrans); - Diseases of the stomach and duodenum associated with Helicobacter pylori (as part of combination therapy) (for pills and capsules).
Contraindications
- liver failure; - renal failure; - children's age up to 12 years (for capsules and pills); - children's age up to 12 months (for a suspension of 200 mg / 5 ml); - children's age up to 6 months (for a suspension of 100 mg / 5 ml); - hypersensitivity to macrolide antibiotics.
Use during pregnancy and lactation
In pregnancy, Hemomycin is prescribed only when the expected benefit of therapy for the mother outweighs the potential risk to the fetus. If necessary, use of the drug during lactation should decide whether to stop breastfeeding for the duration of the drug.
Dosage and administration
In children older than 12 months, a suspension of 200 mg / 5 ml is used, in children over 6 months, a suspension of 100 mg / 5 ml. Children with infections of the upper and lower respiratory tract infections of the skin and soft tissues (except for chronic erythema migrans) Hemomycin in suspension form is prescribed at the rate of 10 mg / kg of body weight 1 time / day for 3 days (course dose - 30 mg / kg). Recommended dosing schemes for Hemomycin depending on the body weight of the child and the concentration of the suspension are presented in the following table. Daily dose (suspension 200 mg / 5 ml) Daily Dose (suspension 100 mg / 5ml) 2.5 kg 10-14 ml (100 mg) - 1/2 dimensional.spoons of 5 ml (100 mg) - 1 mer. spoon15-25 kg 5 ml (200 mg) - 1 mern. spoon 10 ml (200 mg) - 2 mer. spoons 26-35 kg 7.5 ml (300 mg) - 1.5 mer. spoons of 15 ml (300 mg) - 3 mer. spoons36-45 kg 10 ml (400 mg) - 2 mer. spoons of 20 ml (400 mg) - 4 mer. spoonsMore than 45 kg prescribe doses for adults prescribe doses for adults
Side effects
On the part of the digestive system: diarrhea (5%), nausea (3%), abdominal pain (3%); 1% or less - dyspepsia, vomiting, flatulence, melena, cholestatic jaundice, increased activity of liver enzymes, in children - constipation, anorexia, gastritis. On the side of the cardiovascular system: heartbeat, chest pain (1% or less). From the side of the central nervous system: dizziness, headache, vertigo, drowsiness; in children - headache (in the treatment of otitis media), hyperkinesia, anxiety, neurosis, sleep disturbance (1% or less). From the reproductive system: vaginal candidiasis. From the urinary system: nephritis (1% or less). Allergic reactions : rash, angioedema; children have conjunctivitis, pruritus, urticaria. Others: fatigue, photosensitization.
Overdose
Symptoms: nausea, temporary hearing loss, vomiting, diarrhea. Treatment: gastric lavage, conducting symptomatic therapy.
Interaction with other drugs
With simultaneous use of Hemomycin and antacids (aluminum and magnesium), azithromycin absorption is slowed down. Ethanol and food slow down and reduce azithromycin absorption. When co-administered with warfarin and azithromycin (in usual doses), there are no changes in prothrombin time, however, given that warfarin may increase the anticoagulant effect, patients need careful control of prothrombin time. The combined use of azithromycin and digoxin increases the concentration After the simultaneous use of Azithromycin, you can enjoy an increase in the toxicity of the latter to help you to enhance the effect of the company. , felodipine, as well as drugs undergoing microsomal oxidation (carbamazepine, terfenadine, cyclos porin,hexobarbide with heparin.
special instructions
The drug should be prescribed with caution during pregnancy, with arrhythmias (ventricular arrhythmias and lengthening of the QT interval are possible), children with severe impaired liver or kidney function. The drug should not be taken during a meal. drugs. After discontinuation of treatment, hypersensitivity reactions may persist in some patients, which requires specific therapy and medical monitoring.