Hemomycin pills 500 mg 3 pcs
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Active ingredients
Azithromycin
Release form
Pills
Composition
Active ingredient: Azithromycin Concentration of active ingredient (mg): 500 mg
Pharmacological effect
Broad-spectrum antibiotic. Azithromycin is a representative of the macrolide antibiotic subgroup - azalides. It has a bactericidal effect in high concentrations. Hemomycin is active against aerobic gram-positive bacteria: Streptococcus pneumoniae, Streptococcus pyogenes, Streptococcus agalactiae, Streptococcus spp. groups C, F and G, Streptococcus viridans, Staphylococcus aureus; Aerobic Gram-negative bacteria: Haemophilus influenzae, Moraxella catarrhalis, Bordetella pertussis, Bordetella parapertussis, Legionella pneumophila, Haemophilus ducreyi, Helicobacter pylori, Campylobacter jejuni, Neisseria gonor rh o rr o syrhacrus, pylori pylori, neyseroslae neyserophylus pylori, Helicobacter pylori Anaerobic Bacterium
Pharmacokinetics
Asythromycin is rapidly absorbed from the gastrointestinal tract, due to its stability in an acidic environment and lipophilicity. After ingestion of Hemomycin in the dose of 500 mg of azithromycin Cmax in the blood plasma is achieved in 2.5-2.96 hours and is 0.4 mg / l. Bioavailability is 37%. DistributionAzithromycin penetrates well into the respiratory tract, organs and tissues of the urogenital tract, into the prostate gland, into the skin and soft tissues. High tissue concentrations (10–50 times higher than in plasma) and prolonged T1 / 2 are due to the low binding of azithromycin to plasma proteins, as well as its ability to penetrate into eukaryotic cells and concentrate in a low pH environment surrounding the lysosomes. This, in turn, determines a large apparent Vd (31.1 l / kg) and high plasma clearance. The ability of azithromycin to accumulate primarily in lysosomes is especially important for the elimination of intracellular pathogens. It has been proven that phagocytes deliver azithromycin to the site of infection, where it is released during phagocytosis. The concentration of azithromycin in the foci of infection is significantly higher than in healthy tissues (by an average of 24–34%) and correlates with the degree of inflammatory edema. Despite the high concentration in phagocytes, azithromycin does not significantly affect their function. Azithromycin remains in bactericidal concentrations in the focus of inflammation for 5-7 days after the last dose,which allowed developing short (3-day and 5-day) courses of treatment. Metabolism In the liver, azithromycin is demethylated, the resulting metabolites are not active. Excretion The removal of azithromycin from blood plasma takes place in 2 stages: T1 / 2 is 14-20 hours in the range from 8 to 24 hours after taking the drug and 41 hours in the range from 24 to 72 hours, which allows you to use the drug 1 time / day.
Indications
Infectious and inflammatory diseases caused by susceptible microorganisms: infections of the upper respiratory tract and upper respiratory tract (tonsillitis, sinusitis, tonsillitis, otitis media), scarlet fever, infections of the lower respiratory tract (bacterial, including caused by atypical pathogens, pneumonia, bronchitis); infections of the skin and soft tissues (erysipelas, impetigo, secondarily infected dermatoses); infections of the urogenital tract (uncomplicated urethritis and / or cervicitis); Lyme disease (borreliosis), for the treatment of the initial stage (erythema migrans); a disease of the stomach and duodenum associated with Helicobacter pylori (as part of combination therapy).
Contraindications
hypersensitivity to macrolide antibiotics; severely impaired liver and kidney function; lactation period; children under 12 years old. With caution - pregnancy, arrhythmia (ventricular arrhythmias and QT interval are possible), children with severely impaired liver function or kidney problems.
Precautionary measures
The drug should be prescribed with caution during pregnancy, with arrhythmias (ventricular arrhythmias and prolongation of the QT interval are possible) in children with severe impaired liver function or kidney problems.
Use during pregnancy and lactation
In pregnancy, Hemomycin is prescribed only when the expected benefit of therapy for the mother outweighs the potential risk to the fetus. If necessary, use of the drug during lactation should decide whether to stop breastfeeding for the duration of the drug.
Dosage and administration
Azithromycin should always be taken 1 hour before a meal or 2 hours after a meal. The drug is taken 1 time / day. Adults: When the upper and lower respiratory tract infection is prescribed, 500 mg / day is prescribed for 3 days (the course dose is 1.5 g) In infections of the ruts and soft tissues, 1 g is prescribed (4 drops,250 mg) on the 1st day and 500 mg daily from the 2nd to the 5th day (course dose - 3 g). In case of uncomplicated urethritis and / or cervicitis, 1 g is administered once (4 drops, 250 mg each) In case of Lyme disease (Borreliosis), for the treatment of the initial stage (erythema migrans), 1 g (4 cape, 250 mg) is prescribed on the 1st day and 500 mg daily from the 2nd to the 5th day (course dose - 3 g). For diseases of the stomach and duodenum, associated with Helicobacter pylori, 1 g (4 cape, 250 mg) per day is prescribed for 3 days as part of combination therapy. Schennuyu dose should be taken as early as possible, and the next - with a break of 24 h. The drug is prescribed to children over 12 years with infections of the upper and lower respiratory tract, skin and soft tissues at the rate of 10 mg / kg 1 time per day for 3 days ( course dose - 30 mg / kg) or on the first day - 10 mg / kg, then 4 days - 5-10 mg / kg / day. In the treatment of erythema migrans - 20 mg / kg on the first day and 10 mg / kg from 2 to 5 days.
Side effects
On the part of the gastrointestinal tract: diarrhea (5%), nausea (3%), abdominal pain (3%); 1% or less - dyspepsia (flatulence, vomiting), melena, cholestatic jaundice, increased activity of hepatic transaminases; in children, constipation, anorexia, gastritis, a change in taste, candidiasis of the oral mucosa. Since the cardiovascular system: palpitations, chest pain (1% or less). From the nervous system: dizziness, headache, drowsiness; in children, headache (with otitis media therapy), hyperkinesia, anxiety, neurosis, sleep disturbance (1% or less). From the genitourinary system: vaginal candidiasis, nephritis (1% or less). Allergic reactions: rash, angioedema, in children - conjunctivitis, pruritus, urticaria. Others: increased fatigue; photosensitization.
Overdose
Symptoms: nausea, temporary hearing loss, vomiting, diarrhea. Treatment: gastric lavage, conducting symptomatic therapy.
Interaction with other drugs
With simultaneous use of Hemomycin and antacids (aluminum and magnesium), azithromycin absorption is slowed down. Ethanol and food slow down and reduce azithromycin absorption. When co-administered with warfarin and azithromycin (in usual doses), no prothrombin time was detected, but considering warfarin may increase the anticoagulant effect,Patients need careful control of prothrombin time. The combined use of azithromycin and digoxin increases the concentration of the latter. With the simultaneous use of a combination of CURRs, azithromycin and ergotamine and dihydroergotamine, they increase the toxic effect of the latter (vasospasm, dysesthesia). excretion and increases plasma concentration and toxicity of cycloserine, indirect anticoagulants, ethelope; in hepatocytes. Linkozaminy weaken the effectiveness of azithromycin, and tetracycline and chloramphenicol - strengthen. Pharmaceutical interaction Pharmaceutical ki azithromycin incompatible with heparin.
special instructions
You should not take the drug during a meal. It is recommended that the interval of at least 2 hours between taking Hemomycin and antacid drugs. After discontinuation of treatment, some patients may persist hypersensitivity reactions, which requires specific therapy and medical control.