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Active ingredients
Sodium Heparin + Dexpanthenol + Dimethyl Sulfoxide
Release form
Gel
Composition
1 tube contains: Active substance: heparin sodium 500 IU, 1 IU heparin sodium - anticoagulant activity corresponding to the activity of 0.0077 mg II International Standard Heparin (WHO), dimethyl sulfoxide 150 mg, dexpanthenol 25 mg Supplementary substances: isopropanol 353.3 mg, carbomer 940 10 mg, macrogol glyceryl hydroxystearate 10 mg, trolamine 5 mg, mountain pine oil 2.5 mg, rosemary oil 2 mg, lemon oil 0.5 mg, purified water 438.6 mg.
Pharmacological effect
Combined preparation for external use. The action of the drug is due to its active ingredients. Sodium heparin is a direct acting anticoagulant; due to inactivation of biogenic amines and blocking lysosomal enzymes in tissues, it has an anti-inflammatory effect; accelerates the dissolution of microthrombus in the region of the subcutaneous capillaries; improves local blood flow; promotes the regeneration of connective tissue by inhibiting the activity of hyaluronidase. When applied topically, it also has a anti-edema effect. Dexpanthenol (provitamin B5) exhibits an anti-inflammatory and dermatoprotective effect; improving metabolic processes, stimulates regeneration processes. By improving the processes of epithelialization and granulation contributes to the regeneration of damaged tissues. Dimethyl sulfoxide has anti-inflammatory, local anesthetic, analgesic and antimicrobial action; has moderate fibrinolytic activity. Penetrates through the skin, mucous membranes, biological membranes, promotes deeper penetration into the tissues of other components of the drug.
Pharmacokinetics
When applied externally, sodium heparin quickly penetrates the skin: 1 h after application of the gel to the skin, the concentration in the underlying tissues is comparable to the concentration observed after i / v 5000 IU of heparin. Heparin does not penetrate the placental barrier and is not excreted in breast milk. Dexpanthenol - after resorption into the skin turns into pantothenic acid (vitamin B5), which, as part of coenzyme A, participates in numerous metabolic processes. Dimethyl sulfoxide quickly penetrates the skin, mucous membranes membranes, biological membranes (including through the membranes of microbial cells). After application to the skin, Cmax in plasma is reached in 4-8 hours. It is evenly distributed in the body, with the exception of the brain, where its concentration is minimal.Mainly excreted in urine (30% of the dose in the form of unchanged drug and dimethyl sulfone); to a small extent through the lungs and intestines. The metabolite dimethyl sulfide causes a characteristic garlic breath from some patients.
Indications
- hematomas, inflammation of soft tissues, muscles, tendons, tendon sheaths, ligaments after bruises, crush, injuries (including sports); - shoulder scapular periarthritis; - shoulder epicondylitis ("tennis elbow"); bursitis; - deforming osteoarthrosis (in the presence of a periarticular tissue lesion); - neuralgia.
Contraindications
- hypersensitivity to heparin, dimethyl sulfoxide, dexpanthenol and other components of the drug; - bronchial asthma; - pregnancy; - lactation period; - severe hepatic and / or renal failure; - marked cardiovascular disorders (including severe angina pectoris, myocardial infarction, stroke, severe atherosclerosis); - lupus erythematosus; - open wounds at the site of application of the drug; - children under 5 years of age.
Precautionary measures
Application for violations of liver function. Contraindications: severe hepatic impairment. Application of impaired renal function. Contraindications: severe renal insufficiency. Application in children. Contraindications: children under 5 years of age.
Use during pregnancy and lactation
Hepatrombin C gel is contraindicated for use during pregnancy and lactation.
Dosage and administration
Outer. The gel is applied with a thin layer to the affected skin or the skin over the painful area, trying to avoid applying the drug directly to wounds and abrasions. After applying the gel should not be bandaged. Before applying, the skin should be clean and dry. The procedure is repeated 1-2 times a day for 7-10 days or until the symptoms of the disease (pain, swelling, inflammation) disappear. If within 10 days of application of the gel does not occur a distinct improvement, it is recommended to consult a doctor.
Side effects
Hyperemia, itching and burning of the skin in the area of application; allergic reactions (urticaria, angioedema); smell of garlic from the mouth; change in taste.
Overdose
To date, cases of overdose of the drug Gepatrombin C is not described.With proper use of the gel, overdose is unlikely.
Interaction with other drugs
Dimethyl sulfoxide included in the gel significantly enhances the penetration of other drugs through the skin. To prevent the undesirable effects of these substances, other drugs should not be applied to the skin before or after the application of Gepatrombin C.
special instructions
It is not recommended to apply the gel to open wounds. If allergic skin reactions occur, treatment should be stopped.