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Active ingredients
Ketoprofen
Release form
Cream
Composition
1 g of cream contains: Active ingredient: 50 mg.Vspomogatelnye ketoprofen substances: methyl parahydroxybenzoate - 2 mg propyl parahydroxybenzoate - 0.5 mg, propylene glycol - 70 mg isopropyl myristate - 50 mg, petrolatum white - 320 mg, elfakos ST9 - 30 mg Propylene Glycol Glyceryl oleate - 90 mg, magnesium sulfate - 5 mg, purified water - 382.5 mg.
Pharmacological effect
NSAIDs. It has analgesic, anti-inflammatory and anti-edema effect. Inhibits the activity of COX, which leads to inhibition of prostaglandin synthesis. In addition, ketoprofen inhibits lipoxygenase, the synthesis of bradykinin, stabilizes lysosomal membranes and prevents the release of enzymes involved in the inflammatory process. Ketoprofen does not adversely affect the condition of the articular cartilage.
Pharmacokinetics
Absorption Ketoprofen is absorbed very slowly and practically does not accumulate in the body. Bioavailability is 5%. Ketoprofen penetrates into the subcutaneous tissue, ligaments and muscles, synovial fluid and reaches therapeutic concentrations there. The concentration of the drug in the blood plasma is extremely low. Metabolism and elimination of Ketoprofen is metabolized in the liver to form conjugates that are mainly excreted in the urine. Ketoprofen is characterized by slow urine excretion. The pharmacokinetics in special clinical situations of ketoprofen does not depend on the age, the presence of severe renal failure, or cirrhosis of the liver.
Contraindications
Hypersensitivity to ketoprofen, or other components of the drug, as well as salicylates or other nonsteroidal anti-inflammatory drugs. History of asthma attacks after the use of NSAIDs and salicylates. The third trimester of pregnancy. The age of 12 years old. . Open or infected wound. With caution: impaired liver and / or kidney function, erosive and ulcerative lesions of the gastrointestinal tract, blood diseases, bronchial asthma, chronic heart failure Accuracy
Use during pregnancy and lactation
The drug is contraindicated for use in the III trimester of pregnancy. Use in I and II trimesters is possible in cases where the expected benefit of therapy for the mother outweighs the potential risk to the fetus. The use of the drug Ketonal during lactation (breastfeeding) is not recommended.
Dosage and administration
For external use. A small amount of cream (3-5 cm) with light rubbing movements apply a thin layer to the skin of an inflamed or painful area of the body 2-3 times a day. The duration of the course of treatment should not exceed 14 days.
Side effects
Infrequently - skin irritation, allergic skin reactions, hyperemia, itching, rash, burning sensation; rarely - edema, erythema, eczema, including vesicular, bullous and flaktenulnozno that can spread and acquire a generalized nature; purple-like, violent rash; increased sweating, urticaria, dermatitis (contact, exfoliative) photosensitivity, including serious skin reactions from exposure to the sun; purpura, erythema multiforme, dermatitis, resembles lichen, skin necrosis, Stevens-Johnson syndrome. There were reports of local skin reactions, in the future could go beyond the site of application of the drug.
Overdose
Symptoms: irritation, erythema, pruritus. Treatment: discontinue use of the drug. The patient needs to see a doctor.
Interaction with other drugs
Since the concentration of the drug in the blood plasma is extremely low, the manifestation of symptoms of interaction with other drugs (similar symptoms with systemic use) are possible only with frequent and prolonged use. Simultaneous use of other topical forms (ointments, gels) containing ketoprofen or other NSAIDs is not recommended. Simultaneous taking acetylsalicylic acid reduces ketoprofen binding to plasma proteins. Ketoprofen reduces the elimination of methotrexate and increases its toxicity. Interactions with other drugs and the effect on their elimination are not significant. Patients taking coumarin-containing anticoagulants are advised to carry out treatment under the supervision of a physician.
special instructions
It is necessary to avoid getting the cream in the eyes, on the skin around the eyes, mucous membranes. If any side effects appear, you should stop using the drug and consult a doctor. If the patient forgot to apply the cream, you should use it at the time when the next dose should be applied. , but do not double it. Ketonal cream for external use can be used in combination with other dosage forms of the drug Ketonal (capsules, pills, suppositories). The total daily dose, regardless of the dosage form, should not exceed 200 mg. In the event of skin reactions, includingdeveloped when combined with octocrylene-containing drugs, treatment should be discontinued immediately. To reduce the risk of photosensitivity, it is recommended to protect skin-treated areas with clothing from UVA exposure throughout the entire treatment period and for 2 more weeks after discontinuing the gel. Do not use as occlusive dressings. Hands should be thoroughly washed after each application of the preparation. The effect on the ability to drive vehicles and control mechanisms denied There is no effect of Ketonal cream on the ability to drive vehicles and other potentially dangerous activities requiring concentration of attention and psychomotor speed.