Nurofen coated pills 200mg N10
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Active ingredients
Ibuprofen
Release form
Pills
Composition
Ibuprofen 200 mg Auxiliary substances: croscarmellose sodium - 30 mg, sodium lauryl sulfate - 0.5 mg, sodium citrate dihydrate - 43.5 mg, stearic acid - 2 mg, silicon colloid dioxide - 1 mg. The composition of the shell: carmellose sodium - 0.7 mg, talc - 33 mg, acacia gum - 0.6 mg, sucrose - 116.1 mg, titanium dioxide - 1.4 mg, macrogol 6000 - 0.2 mg, black ink [Opacode S-1-277001] (shellac - 28.225%, iron dye black oxide (E172) - 24.65%, propylene glycol - 1.3%, isopropanol * - 0.55%, butanol * - 9.75%, ethanol * - 32.275%, purified water * - 3.25%).
Pharmacological effect
NSAIDs. It has a quick directional effect against pain (analgesic), antipyretic and anti-inflammatory effect. The mechanism of action of ibuprofen, a derivative of propionic acid, is due to the inhibition of the synthesis of prostaglandins - mediators of pain, inflammation and hyperthermic reaction. Indiscriminately blocks COX-1 and COX-2, thereby inhibiting the synthesis of prostaglandins. In addition, ibuprofen reversibly inhibits platelet aggregation. The analgesic effect of the drug lasts up to 8 h.
Indications
Headache . migraine. toothache . painful menstruation. neuralgia backache . muscle pain. rheumatic pain. joint pains. feverish conditions with flu and catarrhal diseases.
Contraindications
Hypersensitivity to ibuprofen or any of the components that make up the drug. complete or incomplete combination of bronchial asthma, recurrent nasal polyposis and paranasal sinuses, and intolerance to acetylsalicylic acid or other NSAIDs (including a history of). erosive and ulcerative diseases of the digestive tract organs (including gastric ulcer and duodenal ulcer, Crohn's disease, ulcerative colitis) or ulcerative bleeding in the active phase or in history (two or more confirmed episodes of peptic ulcer or ulcerative bleeding) a bleeding or perforation of a gastrointestinal ulcer in history, provoked by the use of NSAIDs. severe liver failure or liver disease in the active phase. severe renal failure (Cl creatinine <30 ml / min), confirmed hyperkalemia. decompensated heart failure. period after coronary artery bypass surgery. cerebrovascular or other bleeding. fructose intolerance, glucose-galactose malabsorption, sucrase-isomaltase deficiency. hemophilia and other bleeding disorders (incl.hypocoagulation), hemorrhagic diathesis. pregnancy (III trimester). children's age up to 6 years.
Use during pregnancy and lactation
Use of the drug in the III trimester of pregnancy is contraindicated. The use of the drug in the I – II trimesters of pregnancy should be avoided; if necessary, the drug should be consulted with a doctor. There is evidence that ibuprofen in small quantities can penetrate into breast milk without any negative consequences for the health of the infant, so usually with a short-term admission there is no need to stop breastfeeding. If necessary, long-term use of the drug should consult a doctor to decide whether to stop breastfeeding for the period of use of the drug.
Dosage and administration
Inside, drinking water. Patients with hypersensitivity of the stomach are advised to take the drug with meals. For short term use only. Before taking the drug should be carefully read the instructions. Adults and children over 12 years old: inward on 1 tab. (200 mg) up to 3-4 times per day. To achieve a faster therapeutic effect in adults, the dose can be increased to 2 table. (400 mg) up to 3 times per day. Children from 6 to 12 years: 1 tab. (200 mg) up to 3-4 times a day. the drug can be taken only in the case of a child’s body weight of more than 20 kg. The interval between taking pills should be at least 6 hours. The maximum daily dose for adults is 1200 mg (6 tab.). The maximum daily dose for children from 6 to 18 years old is 800 mg (4 tab.). If while taking the drug for 2–3 days the symptoms persist or worsen, it is necessary to stop treatment and consult a doctor.
Side effects
The risk of side effects can be minimized if you take the drug in a short course, at the minimum effective dose necessary to eliminate the symptoms. In older people, there is an increased frequency of adverse reactions against the background of the use of NSAIDs, especially gastrointestinal bleeding and perforations, in some cases with a fatal outcome. Side effects are predominantly dose-dependent. The following adverse reactions were observed with short-term ibuprofen in doses not exceeding 1200 mg / day (6 tab.).In the treatment of chronic conditions and prolonged use may cause other adverse reactions. The frequency of adverse reactions was estimated based on the following criteria: very often (& # 8805 .1 / 10). often (from & # 8805 .1 / 100 to <1/10). infrequently (from & # 8805 .1 / 1000 to <1/100), rarely (from & # 8805 .1 / 10000 to <1/1000), very rarely (<1/10 000), the frequency is unknown (estimated data frequencies are absent). From the side of blood and lymphatic system: very rarely - blood disorders (anemia, leukopenia, aplastic anemia, hemolytic anemia, thrombocytopenia, pancytopenia, agranulocytosis). The first symptoms of such disorders are fever, sore throat, superficial oral ulcers, flu-like symptoms, severe weakness, bleeding from the nose and subcutaneous hemorrhages, hemorrhages and hemorrhages of unknown etiology. Immune system: infrequently - hypersensitivity reactions, nonspecific allergic reactions and anaphylactic reactions, reactions of the respiratory tract (bronchial asthma, including its exacerbation, bronchospasm, shortness of breath, dyspnea), skin reactions (itching, urticaria, purpura, Quincke's edema, exfoliative and bullous dermatosis, including toxic epidermal necrolysis (Lyell's syndrome), Stevens-Johnson syndrome, erythema multiforme, allergic rhinitis, eosinophilia. very rarely - severe hypersensitivity reactions, including swelling of the face, tongue and larynx, shortness of breath, tachycardia, hypotension (anaphylaxis, angioedema, or severe anaphylactic shock). On the part of the digestive tract: infrequently - abdominal pain, nausea, dyspepsia (including heartburn, bloating). rarely - diarrhea, flatulence, constipation, vomiting. very rarely - peptic ulcer, perforation or gastrointestinal bleeding, melena, bloody vomiting, in some cases with a fatal outcome, especially in elderly patients, ulcerative stomatitis, gastritis. Accuracy is unknown - exacerbation of colitis and Crohn's disease. On the part of the liver and biliary tract: very rarely - abnormal liver function, increased activity of hepatic transaminases, hepatitis and jaundice. On the part of the kidneys and urinary tract: very rarely - acute renal failure (compensated and decompensated) especially with prolonged use, combined with an increase in plasma urea concentration and the appearance of edema, hematuria and proteinuria, nephritic syndrome, nephrotic syndrome, papillary necrosis, interstitial nephritis, cystitis. From the nervous system: infrequently - headache. very rarely - aseptic meningitis.On the part of the cardiovascular system: the frequency is unknown - heart failure, peripheral edema, with prolonged use, the risk of thrombotic complications (for example, myocardial infarction) is increased, and blood pressure is increased. On the part of the respiratory system and mediastinal organs: the frequency is unknown - asthma, bronchospasm, shortness of breath. Laboratory indicators: hematocrit or Hb (may decrease). bleeding time (may increase). plasma glucose concentration (may decrease). creatinine clearance (may decrease). plasma creatinine concentration (may increase). hepatic transaminase activity (may increase). If you experience side effects, you should stop taking the drug and consult a doctor.
special instructions
The risk of side effects can be minimized if you take the drug in a short course, at the minimum effective dose necessary to eliminate the symptoms. In older people, there is an increased frequency of adverse reactions against the background of the use of NSAIDs, especially gastrointestinal bleeding and perforations, in some cases with a fatal outcome. Side effects are predominantly dose-dependent. The following adverse reactions were observed with short-term ibuprofen in doses not exceeding 1200 mg / day (6 tab.). In the treatment of chronic conditions and prolonged use may cause other adverse reactions. The frequency of adverse reactions was estimated based on the following criteria: very often (& # 8805 .1 / 10). often (from & # 8805 .1 / 100 to <1/10). infrequently (from & # 8805 .1 / 1000 to <1/100), rarely (from & # 8805 .1 / 10000 to <1/1000), very rarely (<1/10 000), the frequency is unknown (estimated data frequencies are absent). From the side of blood and lymphatic system: very rarely - blood disorders (anemia, leukopenia, aplastic anemia, hemolytic anemia, thrombocytopenia, pancytopenia, agranulocytosis). The first symptoms of such disorders are fever, sore throat, superficial oral ulcers, flu-like symptoms, severe weakness, bleeding from the nose and subcutaneous hemorrhages, hemorrhages and hemorrhages of unknown etiology. Immune system: infrequently - hypersensitivity reactions, nonspecific allergic reactions and anaphylactic reactions, reactions of the respiratory tract (bronchial asthma, including its exacerbation, bronchospasm, shortness of breath, dyspnea), skin reactions (itching, urticaria, purpura, Quincke's edema, exfoliative and bullous dermatosis, incl.toxic epidermal necrolysis (Lyell's syndrome), Stevens-Johnson syndrome, erythema multiforme), allergic rhinitis, eosinophilia. very rarely - severe hypersensitivity reactions, including swelling of the face, tongue and larynx, shortness of breath, tachycardia, hypotension (anaphylaxis, angioedema, or severe anaphylactic shock). On the part of the digestive tract: infrequently - abdominal pain, nausea, dyspepsia (including heartburn, bloating). rarely - diarrhea, flatulence, constipation, vomiting. very rarely - peptic ulcer, perforation or gastrointestinal bleeding, melena, bloody vomiting, in some cases with a fatal outcome, especially in elderly patients, ulcerative stomatitis, gastritis. Accuracy is unknown - exacerbation of colitis and Crohn's disease. On the part of the liver and biliary tract: very rarely - abnormal liver function, increased activity of hepatic transaminases, hepatitis and jaundice. On the part of the kidneys and urinary tract: very rarely - acute renal failure (compensated and decompensated) especially with prolonged use, combined with an increase in plasma urea concentration and the appearance of edema, hematuria and proteinuria, nephritic syndrome, nephrotic syndrome, papillary necrosis, interstitial nephritis, cystitis. From the nervous system: infrequently - headache. very rarely - aseptic meningitis. On the part of the cardiovascular system: the frequency is unknown - heart failure, peripheral edema, with prolonged use, the risk of thrombotic complications (for example, myocardial infarction) is increased, and blood pressure is increased. On the part of the respiratory system and mediastinal organs: the frequency is unknown - asthma, bronchospasm, shortness of breath. Laboratory indicators: hematocrit or Hb (may decrease). bleeding time (may increase). plasma glucose concentration (may decrease). creatinine clearance (may decrease). plasma creatinine concentration (may increase). hepatic transaminase activity (may increase). If you experience side effects, you should stop taking the drug and consult a doctor.