Oflomelide ointment for external use 50 g
Condition: New product
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Active ingredients
Methyluracil + Ofloxacin + Lidocaine
Release form
Ointment
Composition
1 g of ofloxacin 10 mg dioxomethyl tetrahydropyrimidine (methyluracil) 40 mg lidocaine hydrochloride (in the form of monohydrate) 30 mg. Excipients: macrogol 1500 (polyethylene oxide 1500, low molecular weight polyethylene glycol 1500), macrogol 400 (polyethylene oxide 400, low molecular weight polyethylene glycol 400), propylene glycol, methyl parahydroxybenzoate (nipagin or methyl paraben), propyl parahydroxybenzoate (napalzole).
Pharmacological effect
The combined drug has antimicrobial, anti-inflammatory, local anesthetic, regenerating effect. Ofloxacin is a broad-spectrum antimicrobial agent from the group of fluoroquinolones. It has a bactericidal effect due to the blockade of DNA gyrase in bacterial cells. Highly active against gram-positive microorganisms: Staphylococcus spp. (including Staphylococcus aureus, Staphylococcus epidermidis), Streptococcus spp .; Gram-negative microorganisms: Pseudomonas aeruginosa, Acinetobacter spp., Escherichia coli, Klebsiella spp., Proteus spp., Enterobacter spp., Citrobacter spp .; anaerobes: Propionibacterium acnes; intracellular microorganisms: Chlamydia spp. (including Chlamydia trachomatis), Legionella spp., Mycoplasma spp. Methyluracil is a tissue repair stimulator. It has anabolic activity. Accelerates the processes of cell regeneration in wounds, accelerating the growth and granulation maturation of tissue and epithelialization. Lidocaine has a local anesthetic effect due to the blockade of sodium channels, which prevents the generation of impulses in the terminations of sensitive neurons and conduction of impulses along the nerve fibers. When applied externally dilates blood vessels, has no local irritating action. The water-soluble hydrophilic (hyperosmolar) base of the ointment is a mixture of polyethylene oxides (polyethylene glycols) with a molecular weight of 400 and 1500, providing a dehydrating (moisture-absorbing) effect on tissue, 20 times superior in strength to the hyper-osmotic effect of 10% sodium chloride solution.
Pharmacokinetics
Data on the pharmacokinetics of the drug Oflomelide not provided
Indications
Infected purulent wounds of various localization and etiology in the first (purulent-necrotic) phase of the wound process, including accompanied by severe pain syndrome: - infected II-IV degree burns - pressure ulcers - trophic ulcers - postoperative and post-traumatic wounds and fistulas - wounds after opening abscesses, phlegmon, after surgical treatment of abscessing furuncles, carbuncles, hydradenitis, supers, after atrophy, with an abscess, furdencles, carbuncles, hydradenitis, with an atomic sweat, after a surgical treatment of abscessated furuncles, carbuncles, hydradenitis, atrophic abscesses, after abscess treatment of abscessated furuncles, carbuncles, hydradenitis, with an athema
Contraindications
- pregnancy - lactation period - children and adolescents under 18 years of age - hypersensitivity to the drug components.
Use during pregnancy and lactation
The drug is contraindicated in pregnancy and lactation (breastfeeding).
Dosage and administration
The drug is used externally, 1 time / day for 1-2 weeks. The maximum daily dose should not exceed 100 g of ointment. The duration of treatment depends on the dynamics of cleansing wounds from purulent exudate and the timing of relief of the inflammatory process. After standard treatment of wounds and burns, the ointment is applied directly to the wound surface with a thin layer (after that a sterile gauze bandage is applied) or a gauze bandage with subsequent application to the lesion. Tampons soaked in ointment, loosely fill the cavity of purulent wounds after their surgical treatment, and gauze turunda with ointment is introduced into the fistulous passages. In the treatment of infected burns, the drug is used daily or 2-3 times a week, depending on the amount of purulent discharge.
Side effects
Possible: allergic reactions.
Interaction with other drugs
There are no cases of drug interactions that would reduce the effectiveness and safety of the drugs used.