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Active ingredients
Drotaverine + Caffeine + Naproxen + Paracetamol + Pheniramine Maleate
Release form
Pills
Composition
Active substance: Caffeine + Paracetamol + propyphenazone + Phenobarbital * (Caffeine + Paracetamol + Propyphenazone + Phenobarbital) Concentration of active ingredient (mg) Paracetamol - 325 mg naproxen - 100 mg Caffeine Anhydrous - 50mg, drotaverine hydrochloride - 40 mg, pheniramine maleate - 10 mg.
Pharmacological effect
Combined medication, has analgesic, anti-inflammatory, antispasmodic, antipyretic effect. Paracetamol is an analgesic antipyretic, has antipyretic and analgesic effect due to COX blockade in the central nervous system and the effect on pain centers and thermoregulation. associated with non-selective suppression of the activity of COX, which regulates the synthesis of prostaglandins. Caffeine - a psychogogic agent, causes an expansion of enosnyh vessels in skeletal muscle, heart, kidney; increases mental and physical performance, helps to eliminate fatigue and drowsiness; increases the permeability of histohematic barriers and increases the bioavailability of non-narcotic analgesics, thereby enhancing the therapeutic effect. It has a tonic effect on the brain vessels. Drotaverine - has myotropic antispasmodic effect due to inhibition of PDE 4, acts on the smooth muscles of the gastrointestinal tract, biliary tract, urinary system, vessels. Pheniramin is a blocker of histamine H1 receptors. It has an antispasmodic and mild sedative effect, reduces the effects of exudation, and also enhances the analgesic effect of paracetamol and naproxen.
Pharmacokinetics
Data on the pharmacokinetics of the drug Pentalgin not provided.
Indications
mild and moderate pain syndrome of various genesis (including pain in joints, muscles, sciatica, algomenorrhea, neuralgia, headache, migraine, toothache), feverish states, colds and other diseases accompanied by pain and inflammation.
Contraindications
severe liver failure; severe renal failure; gastric ulcer and duodenal ulcer in the acute phase; bronchial asthma; bronchospasm; anemia, leukopenia; conditions,accompanied by respiratory depression, traumatic brain injury, severe arterial hypertension, acute myocardial infarction, arrhythmias, alcohol intoxication, glaucoma, glucose-6-phosphate dehydrogenase deficiency, children under 12 years of age, hypersensitivity to the components of the drug.
Precautionary measures
With caution should use the drug in elderly patients.
Use during pregnancy and lactation
The drug is contraindicated for use during pregnancy. If you need to use the drug during lactation should stop breastfeeding.
Dosage and administration
The maximum daily dose is 4 pills. The duration of treatment is not more than 3 days as an antipyretic and not more than 5 days as an anesthetic.
Side effects
Allergic reactions: skin rash, pruritus, urticaria, angioedema; From the hematopoietic organs: thrombocytopenia, leukopenia, agranulocytosis, anemia, methemoglobinemia; From the nervous system: agitation, anxiety, increased reflexes, tremor, headache, headache, headache, headache, headache, headache, headache, headache, headache, headache, headache, headache, headache, headache, headache, headache, headache, headache, headache, headache, headache, headache, tremor, tremors, anemia, methemoglobinemia decreased concentration; From the side of the cardiovascular system: palpitations, arrhythmias, increased blood pressure; From the side of the digestive system: erosive and ulcerative lesions of the gastrointestinal tract, nausea, rv that, epigastric discomfort, abdominal pain, constipation, abnormal liver function; From the urinary system: renal dysfunction; From the senses: hearing loss, tinnitus, increased intraocular pressure in patients with angle-closure glaucoma; Other: dermatitis, tachypnea (increased breathing).
Overdose
Symptoms: pallor of the skin, anorexia (lack of appetite), abdominal pain, nausea, vomiting, gastrointestinal bleeding, agitation, anxiety, confusion, tachycardia, arrhythmia, hyperthermia (fever), frequent urination, headache, tremor or muscle twitching; epileptic seizures, increased activity of hepatic transaminases, hepatonecrosis, an increase in prothrombin time. Symptoms of abnormal liver function may appear 12-48 hours after an overdose.In severe overdose, liver failure develops with progressive encephalopathy, coma, or death; acute renal failure with tubular necrosis; arrhythmia, pancreatitis. If you suspect an overdose, you should immediately seek medical help. Treatment: gastric lavage followed by the administration of activated carbon. Acetylcysteine is a specific antidote for paracetamol poisoning. The introduction of acetylcysteine is important within 8 hours after taking paracetamol. In case of gastrointestinal bleeding, it is necessary to administer antacids and gastric lavage with ice-cold 0.9% sodium chloride solution; maintaining lung ventilation and oxygenation; with epileptic seizures - in / in the introduction of diazepam; maintaining fluid and salt balance.
Interaction with other drugs
While taking the drug Pentalgin with barbiturates, tricyclic antidepressants, rifampicin, ethanol increases the risk of hepatotoxic action (these combinations should be avoided). Paracetamol enhances the effect of anticoagulants of indirect action and reduces the efficacy of uricosuric drugs. increases the risk of acute pancreatitis. Inhibitors of microsomal oxide effects (including cimetidine) reduce the risk of hepatotoxic effects of paracetamol. When used simultaneously with diflunisal, the plasma concentration of paracetamol increases by 50%, which increases the risk of developing hepatotoxicity. and methotrexate, reduces the excretion of lithium and increases its concentration in the blood plasma. When combined use of caffeine and barbiturates, primidone, anticonvulsant zhnyh means (hydantoin derivatives, especially phenytoin) may increase the metabolic clearance and increased caffeine; while taking caffeine and cimetidine, oral contraceptives, disulfiram, ciprofloxacin, norfloxacin - reducing the metabolism of caffeine in the liver (slowing its excretion and increasing concentrations in the blood). Simultaneous consumption of caffeine-containing drinks and other means of stimulating the central nervous system,It can lead to excessive stimulation of the CNS. With simultaneous use, drotaverine may weaken the anti-Parkinsonian effect of levodopa. With simultaneous use of pheniramine with tranquilizers, hypnotics, MAO inhibitors, ethanol may increase the inhibitory effect on the central nervous system.
special instructions
It is necessary to avoid the simultaneous use of the drug Pentalgin with other agents containing paracetamol and / or NSAIDs, as well as with means to alleviate the symptoms of a cold, flu and nasal congestion. When using the drug Pentalgin for more than 5-7 days, monitor the performance of the peripheral blood and liver function. Paracetamol distorts the results of laboratory studies of glucose and uric acid in the blood plasma. If it is necessary to determine the 17-keto steroids, Pentalgin should be canceled 48 hours before research. It should be borne in mind that naproxen increases bleeding time. The effect of caffeine on the central nervous system depends on the type of nervous system and may manifest as excitation and inhibition of higher nervous activity. During treatment, you should not drink alcoholic beverages. Effect on driving ability and control mechanisms In the period treatment, the patient must take care when driving vehicles and engaging in other potentially hazardous activities that require increased concentration and attention. trots of psychomotor reactions.