More info
Active ingredients
Furazidin
Release form
Pills
Composition
1 tablet contains: Active substance: furazidin 50 mg. Adjuvants: corn starch - 27.5 mg, sucrose - 13.75 mg, silica, anhydrous colloidal silicon dioxide - 1.25 mg, stearic acid - 7.5 mg.
Pharmacological effect
Antimicrobial agent of broad-spectrum, belongs to the group of nitrofurans. Under the influence of nitrofurans, the respiratory chain and the tricarboxylic acid cycle (Krebs cycle) are suppressed, and other biochemical processes of microorganisms are inhibited, resulting in the destruction of their membrane or cytoplasmic membrane. It is active against gram-positive cocci: Streptococcus spp., Staphylococcus spp .; Gram-negative bacilli: Escherichia coli, Salmonella spp., Shigella spp., Proteus spp., Klebsiella spp., Enterobacter spp .; protozoa: Lamblia intestinalis and other antibiotic-resistant microorganisms. Regarding Staphylococcus spp., Escherichia coli, Aerobacter aerogenes, Bacterium citrovorum, Proteus mirabilis, Proteus morganii furazidin, compared to other nitrofuranes, is more active than the other nitrofuranes, Proteus mirabilis, Proteus mirabilis, Proteus mirabilis, Furazidine. ranges from 1: 100,000 to 1: 200,000. The bactericidal concentration is about 2 times greater. As a result of the action of nitrofurans, microorganisms secrete less toxins, and therefore it is possible to improve the patient’s general condition even before pronounced growth inhibition ikroflory. Nitrofurans activate the body's immune system: they increase the titer of complement and the ability of leukocytes to phagocytose microorganisms. In therapeutic doses, furazidine stimulates leukopoiesis. Furazidine resistance develops slowly and does not reach a high degree.
Pharmacokinetics
After oral administration, furazidin is absorbed from the small intestine by passive diffusion. The absorption of nitrofurans from the distal segment of the small intestine exceeds the absorption from the proximal and medial segments by 2 and 4 times, respectively (should be considered when simultaneously treating urogenital infections and diseases of the gastrointestinal tract, in particular chronic enteritis). Nitrofurans are poorly absorbed from the colon. Cmax in the blood plasma lasts from 3 to 7 or 8 hours, in the urine furazidin is detected after 3-4 hours. In the body, furazidin is distributed evenly. Clinically important is the high content of the drug in the lymph (delaying the spread of infection through the lymphatic ducts). In bile, its concentration is several times higher than in serum, and in the cerebrospinal fluid - several times lower than in serum.In saliva, the content of furazidine is 30% of its concentration in serum. The concentration of furazidin in the blood and tissues is relatively low, which is associated with its rapid release, while the concentration in the urine is much higher than in the blood. It is slightly metabolized (<10%). , partially subjected to reverse reabsorption in the tubules. At low concentrations of furazidine in the urine, filtration and secretion predominate, at high concentrations, secretion decreases and reabsorption increases. Furazidin, being a weak acid in acid urine does not dissociate, is subjected to intensive reabsorption, which can enhance the development of systemic side effects. With alkaline urine, the excretion of furazidine increases. When the excretory function of the kidneys decreases, the intensity of metabolism increases.
Indications
For oral administration: urogenital infections (acute cystitis, urethritis, pyelonephritis); gynecological infections; skin and soft tissue infections; severe infected burns; with prophylactic purposes for urological operations (including cystoscopy, catheterization). For external and local use: infectious and inflammatory diseases of the oral cavity and pharynx, infected wounds.
Contraindications
Chronic renal failure severe; pregnancy; lactation period (breastfeeding); children up to 4 years; hypersensitivity to furazidine and other nitrofurans.
Use during pregnancy and lactation
The drug is contraindicated during pregnancy and lactation (breastfeeding).
Dosage and administration
Is ingested after a meal. Adults - 50-100 mg 3 times / day, children over 3 years old - 25-50 mg (no more than 5 mg / kg body weight) 3 times / day. The course of treatment is 7-10 days. If necessary, repeat the course of treatment should be a break for 10-15 days. For the prevention of infection (including during urological operations, cystoscopy, catheterization) - 50 mg once 30 minutes before the procedure. Apply externally 2-3 times / day for washing wounds or wetting the dressing material. Apply topically 2-3 times / day in the form of rinsing the mouth and throat.
Side effects
On the part of the digestive system: rarely - nausea, vomiting, loss of appetite, abnormal liver function. On the part of the central nervous system and peripheral nervous system: rarely - headache, dizziness, polyneuritis. Allergic reactions: rarely - skin rash (including papular rash ).
Overdose
Symptoms: neurotoxic reactions, polyneuritis, abnormal liver function, acute toxic hepatitis. Treatment: discontinuation of the drug, intake of large amounts of fluid, symptomatic therapy, antihistamine medicines, vitamins of group B. There is no specific antidote.
Interaction with other drugs
When combining furazidina with ristomycin, chloramphenicol, sulfonamides increases the risk of hematopoietic depression (should not be used simultaneously). It is not recommended to use drugs capable of acidifying urine (including ascorbic acid, calcium chloride) along with nitrofurans.
special instructions
To reduce the likelihood of side effects, furazidine is washed down with a large amount of fluid. If side effects appear, use should be discontinued (toxic effects are more common in patients with reduced renal excretory function). During treatment, it is recommended that the patient refrain from drinking alcohol, as side effects may increase. take a double dose to compensate for the missed dose. Use with caution when glucose-6-phosphate dehydrogenase deficiency.