artrosilene aerosol 15% 25 ml
Condition: New product
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Active ingredients
Ketoprofen
Release form
Spray
Composition
1 g of aerosol foam for external use contains 15%: Active ingredients: ketoprofen lysine salt 150 mg. Auxiliary substances: polysorbate, polypropylene, povidone, non-rholenic liquid, benzyl alcohol, purified water; propellant - propane-butane.
Pharmacological effect
NSAIDs. It has anti-inflammatory, analgesic and antipyretic effects. When applied externally, artrosilene reduces the manifestations of inflammation and pain in the affected joints, tendons, ligaments, muscles. When articular syndrome causes a reduction in pain in the joints at rest and when moving, reducing morning stiffness and swelling of the joints. Ketoprofena lysine salt does not have a catabolic effect on articular cartilage
Pharmacokinetics
When skin application is absorbed slowly; a dose of 50–150 mg in 5–8 h creates a plasma concentration level of 0.08–0.15 mcg / ml. Practically does not accumulate in the body. Bioavailability is about 5%.
Indications
Diseases of the musculoskeletal system (including rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, osteoarthritis of the peripheral joints and spine, rheumatic soft tissue lesions); muscle pain of rheumatic and non-rheumatic origin; traumatic injuries of soft tissues
Contraindications
Hypersensitivity, incl. other NSAIDs, aspirin asthma, lactation, gastric ulcer and duodenal ulcer in the acute phase, peptic ulcer, ulcerative colitis in the acute phase, Crohn's disease, diverticulitis, hemophilia and other disorders of blood coagulation, chronic renal failure, weeping dermatosis, eczema; violation of the integrity of the skin; children under 6 years old. With caution: bronchial asthma, chronic heart failure, old age. pregnancy (I, II trimester). hepatic porphyria, erosive-ulcerative lesions Gastrointestinal tract, severe liver and kidney dysfunction, children under 12 years.
Use during pregnancy and lactation
It can not be used in the third trimester of pregnancy. Experience with Artrozilena during lactation is not available. Use in the I and II trimesters is possible only after consulting a doctor.
Dosage and administration
When applied externally, a single dose of aerosol is 1-2 g (walnut volume). The preparation should be applied 2-3 times / day, gently rubbing until completely absorbed. The duration of treatment should not exceed 10 days (without consulting a doctor).
Side effects
Local reactions: erythema, rash, burning sensation, itching. Sometimes local reactions can spread beyond the area of application of the drug, very rarely can be serious and generalized. Allergic reactions: dermatitis, contact eczema, urticaria, bullous dermatitis, photosensitization reactions. Systemic adverse reactions, such as renal dysfunction, occur rarely. development of any adverse effects should consult a doctor
Overdose
Extremely low degree of systemic absorption of the active ingredients of the drug for external use makes overdosing almost impossible. If accidental ingestion of large quantities of the drug (more than 20 g), the occurrence of systemic adverse reactions characteristic of NPVS may occur. Treatment: gastric lavage, intake of activated carbon
Interaction with other drugs
Inductors of microsomal oxidation in the liver (phenytoin, ethanol, barbiturates, flumecinol, rifampicin antihypertensives and diuretics. Joint administration with other NSAIDs, GCS, ethanol, corticotropin can lead to the formation of ulcers and the development of gastrointestinal bleeding, and an increased risk of developing impaired renal function. Simultaneous administration with oral anticoagulants, heparin, thrombolytics, antiaggregants, cefoperadose. cefamandol and cefotetan increases the risk of bleeding. Increases the hypoglycemic effect of insulin and oral hypoglycemic drugs (dose recalculation is necessary). Together with sodium valproate assignment causes a disturbance aggregation trombotsitov.Povyshaet plasma concentration of verapamil and nifedipine, lithium, metotreksata.Antatsidy colestyramine and reduce absorption.
special instructions
The drug should be applied only to intact skin. Avoid contact with eyes and mucous membranes.In order to avoid manifestations of hypersensitivity and photosensitivity, it is recommended to avoid exposure of the skin to sunlight during the course of treatment.