Estrogel transdermal gel 80g
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Active ingredients
Estradiol
Release form
Gel
Composition
Active ingredient: 17β-estradiolActivating substances: carbomer (Carbopol 980), trolamine (triethanolamine), ethanol, purified water. Concentration of the active substance (mcg): 600 mcg;
Pharmacological effect
Estrogen preparation for external use. Estradiol, the active substance of the drug Oestrogel, is an estrogen. Against the background of Estrogel treatment, the severity of menopausal syndrome (including hot flashes, increased sweating, dry vagina, low mood) is significantly reduced. Eströzel’s clinical efficacy in treating the symptoms of the postmenopausal period is comparable to that when taking estrogen drugs inside. The use of the drug helps to reduce the total cholesterol concentration without changing the cholesterol / HDL ratio. vitamin K-dependent coagulation factors (II, VII, IX, X), reduces the concentration of antithrombin III.
Pharmacokinetics
Absorption and distribution When the gel is applied, ethanol evaporates quickly and estradiol penetrates the skin. However, most of it enters the systemic circulation immediately, and a certain amount of estradiol is retained in the subcutaneous fat and released into the systemic circulation gradually. The estradiol in the blood reaches C 3-4 after 3-4 hours. Bioavailability is 82%. does not undergo a first-pass effect, which provides a higher concentration of estradiol in the blood plasma compared to oral forms. Metabolism and elimination of estradiol when using Estrogel corresponds to exists biotransformation and excretion of natural estrogen.
Indications
Estrogen-deficient conditions (heat sensation, sweating, sleep disturbances, dizziness, irritability, atrophic changes in the organs of the urogenital system), postmenopausal osteoporosis (prophylaxis).
Contraindications
Malignant tumors of the breast and endometrium, severe abnormal liver function, uterine bleeding of unknown etiology, thromboembolic diseases, pregnancy.
Precautionary measures
Do not exceed the recommended dose. With caution, you should use the drug for ischemic heart disease, circulatory failure, diabetes, migraine, bronchial asthma, inflammatory diseases of the female genital organs, epilepsy, severe hypertension, abnormal liver function, a history of thrombophlebitis, thrombosis or thrombosis, thrombosis, or thrombosis, thrombosis, thrombosis, thrombosis, thrombosis, thrombosis, thrombosis, thrombosis, thrombosis, thrombosis, thrombosis, thrombosis, thrombosis, thrombosis or thrombosis, thrombosis or thrombosis, thrombosis, thrombosis, thrombosis, thrombosis, thrombosis or thrombosis, thrombosis or thrombosis, thrombosis, thrombosis, thrombosis, thrombosis, thrombosis or thrombosis, thrombosis, thrombosis, thrombosis, thrombosis, thrombosis, thrombosis, thrombosis or thrombosis. against the background of the use of estrogen, familial hyperlipoproteinemia, pancreatitis, endometriosis, gallbladder disease in history (especially cholelithiasis), jaundice in history (in t. . During previous pregnancy), hepatic porphyria, leiomyoma, hypercalcemia associated with bone metastases of breast cancer.
Use during pregnancy and lactation
Oestrogel is contraindicated for use during pregnancy and during breastfeeding.
Dosage and administration
The use of the drug Oestrogel should be carried out by the woman; in the morning or in the evening, preferably on clean skin. 1 dose of the applicator corresponds to 2.5 g of gel and contains 1.5 mg of estradiol. You should apply 1-2 doses of the applicator (2.5 g of gel) with a thin layer on the skin of the abdomen, lumbar region or forearms until complete absorption of 1 time / day. Application is considered correct and effective if the gel is absorbed completely within 2-3 minutes. If the sticky consistency persists for more than 5 minutes after application, it means that too little surface area of the skin is covered with the gel. The area of application should be at least the area of two palms. Oestrogel is prescribed continuously or cyclically. Dose and duration of therapy set individually.
Side effects
Headache, nausea, breast tension, spotting, glandular endometrial hyperplasia, skin irritation.
Overdose
Symptoms: nausea, vomiting, in some cases - metrorrhagia. Treatment: drug withdrawal, symptomatic therapy.
Interaction with other drugs
With simultaneous use, estrogens may reduce the effect of indirect anticoagulants, hypotensive and hypoglycemic drugs (correction of the dosage regimen of hypoglycemic drugs may be necessary). When used simultaneously, estrogens increase the effectiveness of hypolipidemic drugs. In the simultaneous use of estrogens and drugs that induce microsomal enzymes (m . h.barbiturates, carbamazepine, griseofulvin, rifampicin), it is possible to reduce the concentration of estradiol in the blood plasma. When used simultaneously, estrogens weaken the effect of male sex hormones, diuretic drugs. Anesthesia accelerates estradiol metabolism. With simultaneous use of estrogen with phenylbutazone and some antibiotics (including ampicillin, p iffampicin) decreases the concentration of estradiol in the blood plasma, which is associated with changes in the microflora in the intestine. When used simultaneously with estrogens, folic acid and thyroid hormone preparations increase the effect of estradiol.
special instructions
Before treatment, it is necessary to conduct a gynecological examination, and during long-term therapy it should be carried out at least 1 time per year. Estradiol treatment should be combined with gestagens as recommended by the doctor. the risk of developing breast and endometrial cancers (depending on the duration of treatment and the dose of estrogen). Hyperplasia (atypical or glandular) often precedes endometrial cancer. The combination of estrogen and progestogen has a protective effect on the endometrium. Treatment should be stopped within 4-6 weeks. before the planned surgical treatment. It is not a contraceptive and does not protect against pregnancy. If irregular menstrual discharge occurs during treatment (in women with an intact uterus), diagnostic curettage is necessary to exclude a malignant uterine neoplasm. other localization of thromboembolism, the appearance of jaundice, the amplification or the emergence of previously non-existent migraine-like pains, sudden violation rhenium significant increase AD.Sleduet systematically monitoring of liver function and blood pressure, blood glucose in diabetes.