Flagyl coated pills 250mg N20
Condition: New product
999 Items
Rating:
Be the first to write a review!
More info
Active ingredients
Metronidazole
Release form
Pills
Composition
The active substance is metronidazole. Excipients: wheat starch - 82.15 mg, povidone - 17.5 mg, magnesium stearate - 0.35 mg. The composition of the shell: hypromellose - 2.1 mg, macrogol 20000 - 0.7 mg.
Pharmacological effect
It has a broad spectrum of activity in relation to anaerobic microorganisms (Peptostreptococcus, Clostridium. Crypters, and Khypus. anaerobes
Pharmacokinetics
When ingested, flagel is quickly and almost completely absorbed (approximately 80% in 1 hour). Food intake does not affect the absorption of the drug. Bioavailability is approximately 100%. After ingestion of 500 mg of the drug, the plasma concentration is after 1 hour - 10 μg / ml, and after 3 hours - 13.5 μg / ml. The half-life is equal to 8-10 hours, communication with blood proteins is insignificant and does not exceed 10-20%. The drug quickly penetrates into tissues (lungs, kidneys, liver, skin, bile, cerebrospinal fluid, saliva, seminal fluid, vaginal secretions), into breast milk and passes through the placental barrier. About 30-60% of metronidazole is metabolized by hydroxylation, oxidation and glucuronidation. The main metabolite (2-hydroxymetronidazole) also has an antiprotozoal and antimicrobial effect. Removal of the drug is carried out at 40-70% through the kidneys (in unchanged form - about 35% of the dose). In patients with impaired renal function, after repeated administration, cumulation of metronidazole in serum may be observed.
Indications
Protozoal infections: extraintestinal amebiasis, including amebic liver abscess, intestinal amebiasis (amoebic dysentery), trichomoniasis, balantidiasis, giardiasis, cutaneous leishmaniasis, trichomonas vaginitis, trichomonas urethritis; - infections caused by Bacteroides spp. (including Bacteroides fragilis, Bacteroides distasonis, Bacteroides ovatus, Bacteroides thetaiotaomicron, Bacteroides vulgatus): infections of bones and joints, infections of the central nervous system, including meningitis, brain abscess, bacterial endocarditis, pneumonia, empyema, and lung abscess, sepsis; - infections caused by Clostridium spp. ovarian infections of the vaginal fornix); pseudomembranous colitis (associated with antibiotics); gastritis or duodenal ulcer associated with Helicobacter pylori (complex therapy); th gut, adrectal region, appendectomy, gynecological surgery).
Contraindications
Hypersensitivity to imidazoles. Organic lesions of the central nervous system. Blood diseases, including leukopenia in history. Hepatic insufficiency (in the case of the appointment of large doses). Pregnancy. Breast-feeding
Precautionary measures
Since the simultaneous intake of the drug with alcohol can have an effect similar to that of disulfiram (fever, vomiting, tachycardia), patients should be warned that during treatment with flagelom should not drink alcoholic beverages or drugs containing alcohol. Long-term administration of the drug is preferably carried out under the control of blood formulas. In case of leukopenia, the possibility of continuing treatment depends on the risk of developing an infectious process. When treating Trichomonas vaginitis in women, it is necessary to abstain from sex. Necessarily simultaneous treatment of sexual partners. The treatment does not stop during menstruation. After treatment of trichomoniasis, control tests should be carried out for 3 consecutive cycles before and after menstruation. After giardiasis treatment, if symptoms persist, after 3–4 weeks to perform 3 feces analyzes at intervals of several days (in some successfully treated patients, lactose intolerance caused by invasion may persist for several weeks or months, recalling the symptoms of giardiasis). Treatment should be discontinued when signs of impaired motor coordination appear. It must be taken into account that metronidazole can immobilize treponemas, which leads to a false-positive Nelson test. Impact on the ability to drive and other mechanismsIn connection with the possibility of dizziness and other side effects associated with taking the drug, it is recommended to refrain from driving and other mechanisms
Use during pregnancy and lactation
Contraindicated
Dosage and administration
Inside For amebiasis, flagella is administered orally for 7 days at a dose of 1.5 g / day for 3 doses (adults). Gumliosis is treated for 5 days: adults are prescribed 750–1000 mg / day, children 6–10 years old - 375 mg / day ( 1.5 tab.) And children 10-15 years old - 500 mg / day (2 tab.). For children under 6 years of age, it is preferable to use metronidazole in the form of a suspension. When trichomoniasis in women (urethritis and vaginitis), flagyl is administered once a dose of 2 g or as a course of treatment for 10 days: 1 tab. (250 mg) 2 times / day. In case of trichomoniasis in men (urethritis), flagyl is administered once a dose of 2 g or as a course of treatment for 10 days, 1 tab.(250 mg) 2 times / day. For nonspecific vaginitis, 500 mg of Flagil is used 2 times / day for 7 days. When treating anaerobic infections, adults should be prescribed flagel for 1-1.5 g / day. For severely impaired renal function (CC less than 10 ml / min) it is recommended to reduce the daily dose of the drug by 2 times
Side effects
On the part of the gastrointestinal tract: nausea, metallic taste in the mouth, dry mouth, decreased appetite, glossitis, stomatitis, pancreatitis, anorexia, epigastric pain, vomiting, diarrhea, constipation. On the nervous system: headache, dizziness, poor coordination of movements ataxia, confusion, irritability, depression, irritability, weakness, insomnia, convulsions, confusion, hallucinations, peripheral neuropathy (especially with prolonged use). Allergic reactions: urticaria, skin rash, skin flushing, s false nose, fever, artralgii.So the urinary system: dysuria, polyuria, cystitis, incontinence, candidiasis possibly urine staining reddish-brown tsvet.Prochie: neutropenia, leukopenia, flattening of the T wave on an electrocardiogram
Overdose
Can be observed: leukopenia, neuropathy, ataxia, vomiting. As the specific antidote of metronidazole is not known, it is recommended to carry out supported symptomatic therapy.
Interaction with other drugs
It causes intolerance to ethanol. Simultaneous use with disulfiram can lead to the development of various neurological symptoms (the interval between administration is at least 2 weeks). It intensifies the effect of indirect anticoagulants, which leads to an increase in the time of prothrombin formation. Cimetidine inhibits metronidazole metabolism, which can lead to an increase concentrations in serum and an increased risk of side effects. Simultaneous prescription of drugs that stimulate microsomal oxide enzymes eniya in liver (phenobarbital, phenytoin), may accelerate the elimination of metronidazole, resulting in decreases its concentration in plasma.
special instructions
Since the simultaneous intake of the drug with alcohol can have an effect similar to that of disulfiram (fever, vomiting, tachycardia), patients should be warned that during treatment with flagelom should not drink alcoholic beverages or drugs containing alcohol. Long-term administration of the drug is preferably carried out under the control of blood formulas. In case of leukopenia, the possibility of continuing treatment depends on the risk of developing an infectious process.When treating Trichomonas vaginitis in women, it is necessary to abstain from sex. Necessarily simultaneous treatment of sexual partners. The treatment does not stop during menstruation. After treatment of trichomoniasis, control tests should be carried out for 3 consecutive cycles before and after menstruation. After giardiasis treatment, if symptoms persist, after 3–4 weeks to perform 3 feces analyzes at intervals of several days (in some successfully treated patients, lactose intolerance caused by invasion may persist for several weeks or months, recalling the symptoms of giardiasis). Treatment should be discontinued when signs of impaired motor coordination appear. It must be taken into account that metronidazole can immobilize treponemas, which leads to a false-positive Nelson test. Impact on the ability to drive and other mechanismsIn connection with the possibility of dizziness and other side effects associated with taking the drug, it is recommended to refrain from driving and other mechanisms