Tanakan oral solution 30ml
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Active ingredients
Ginkgo bilobate leaf extract
Release form
Solution
Composition
100 ml of solution contains: extract of ginkgo bilobate leaves (EGb 761;) 4 g, incl. flavonol glycosides 24%, ginkgolide bilobalides 6%. Adjuvants: sodium saccharin - 500 mg, orange flavoring - 0.75 ml, lemon flavoring - 0.75 mg, ethanol 96% - 59 ml, purified water - up to 100 ml.
Pharmacological effect
An angioprotective agent of plant origin. A standardized and titrated preparation of plant origin, the effect of which is due to the effect on the metabolic processes in the cells, the rheological properties of the blood, and the vasomotor reactions of the blood vessels. The preparation improves the supply of oxygen and glucose to the brain. Normalizes the tone of the arteries and veins, improves microcirculation. It helps to improve blood flow, prevents erythrocyte aggregation. It has an inhibitory effect on platelet activation factor. Improves metabolic processes, has an antihypoxic effect on tissues. Interferes with the formation of free radicals and lipid peroxidation of cell membranes. Affects the release, reuptake and catabolism of neurotransmitters (norepinephrine, acetylcholine, dopamine, serotonin) and their ability to bind to membrane receptors.
Pharmacokinetics
Ginkgolides A and B and bilobalides have a bioavailability of 80% to 90% when taken orally. Cmax is reached in 1-2 hours; T1 / 2 ranges from 4 hours (ginkgolide A and bilobalide) to 10 hours (ginkgolide B). The main route of elimination is the kidneys.
Indications
Cognitive and neurosensory deficiency of various genesis (with the exception of Alzheimer's disease and dementia of various etiologies). Intermittent claudication in chronic obliterating arteriopathies of the lower extremities (2 degrees in Fontein). Disorders of vascular genesis, reduction in its acuity. coordination disorders of predominantly vascular genesis. Illness and Raynaud's syndrome.
Contraindications
Erosive gastritis in the acute phase. Gastric and duodenal ulcer in the acute phase. Acute cerebral circulation disorders. Acute myocardial infarction. Low blood clotting. Congenital galactosemia, lactase deficiency,lactose intolerance, glucose / galactose malabsorption syndrome (for pills). Children and adolescents under 18 years. craniocerebral injuries and diseases of the brain, since the drug in the form of a solution contains 450 mg of ethyl alcohol per dose (1 dose).
Precautionary measures
C caution should be prescribed to patients with alcoholism, liver diseases, head injuries and brain diseases, since the drug in the form of a solution contains 450 mg of ethyl alcohol per dose (1 dose).
Use during pregnancy and lactation
The use of the drug Tanakan is contraindicated during pregnancy and lactation (breastfeeding) due to the lack of clinical data on the use of the drug in this group of patients.
Dosage and administration
Assign adults inside 40 mg (1 tab. Or 1 ml of oral solution) 3 times / day with meals. The tablet should be taken with half a glass of water. Solution for oral administration should be dissolved in half a glass of water. When taking the drug in the form of a solution for oral administration should use the attached pipette dispenser (1 dose = 1 ml of solution). The minimum course of treatment is at least 3 months. Increasing the duration and conducting repeated courses of treatment is possible on the recommendation of a doctor.
Side effects
Allergic reactions redness, skin rash, swelling, itching, urticaria. From the blood coagulation system, reduced blood clotting and the possibility of bleeding (with prolonged use). Dermatological reactions eczema. nausea, vomiting, abdominal pain, dyspepsia, diarrhea. In case of adverse reactions, the patient should stop taking the drug and consult a doctor.
Overdose
Currently, overdose cases are not registered.
Interaction with other drugs
In clinical studies with EGb 761, both inhibition and induction of cytochrome P450 isoenzymes were detected.With co-administration of EGb 761 with midazolam, the level of the latter changed presumably due to exposure to CYP3A4. Thus, care must be taken when sharing EGb 761 and drugs metabolized by the CYP3A4 isoenzyme and having a low therapeutic index. Patients who regularly receive acetylsalicylic acid (as an antiplatelet agent), anticoagulants (direct and indirect action) and other drugs that lower blood coagulability. With simultaneous use of Tanakan in the form of an oral solution with antibiotics of the cephalosporins group (cefamandol, cefopera Azone, Latonexia, Gentamicin ornidazole, secnidazole, tinidazole), ketoconazole, cytostatics (procarbazine), tricyclic antidepressants, tranquilizers, such reactions as hyperthermia may occur, hyperemia of the skin, vomiting, palpitations, since 1 dose of Tanakan in the form of oral solution contains 450 mg of ethyl alcohol.
special instructions
Before using the drug, consultation with a doctor is necessary. Improvement of the condition is manifested 1 month after the start of treatment. One single dose of the oral solution contains 450 mg of ethyl alcohol (57% v / v), the maximum daily dose is 1.35 g of ethyl alcohol. Effect on ability to drive motor vehicles and control mechanisms. During the period of taking the drug, it is not recommended to perform potentially hazardous activities that require high concentration of attention and psychomotor speed of reactions (including REMEDIES work with moving mechanisms), since the the drug may cause dizziness and the solution contains ethyl alcohol.