Zyrtec drops for oral administration 10 ml
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Description
Bronchogen is a biologically active food supplement. The source of peptides with a tissue-specific effect on the cells of the lungs and bronchial mucosa. The results of clinical studies have shown that the peptides that make up the Bronchogen contribute to reducing the frequency of coughing episodes, eliminating the effects of bronchospasm and reducing the amount of secreted sputum.
Active ingredients
Cetirizine
Release form
Solution
Composition
AKS-B peptide complex (alanine, glutamic acid, aspartic acid, leucine) - Bronchogen - 100 mcg. Auxiliary substances: MCC, beet sugar, lactose, starch, tween-80.
Pharmacological effect
Antiallergic drug. Histamine H1 receptor blocker, competitive histamine antagonist, hydroxyzine metabolite. It prevents the development and facilitates the course of allergic reactions, has antipruritic and anti-exudative action. It affects the early histamine-dependent stage of allergic reactions, limits the release of inflammatory mediators at a late stage of an allergic reaction, reduces the migration of eosinophils, neutrophils and basophils, stabilizes the membranes of mast cells. Reduces capillary permeability, prevents the development of tissue edema, relieves spasm of smooth muscles. Eliminates skin reactions to the introduction of histamine, specific allergens, as well as cooling (with cold urticaria). Reduces histamine-induced bronchoconstriction in bronchial asthma of the lungs. Practically has no anticholinergic and antiserotoninovogo action. In therapeutic doses, it has almost no sedative effect. After a single dose of cetirizine in a dose of 10 mg, the effect begins after 20 minutes (in 50% of patients) and after 60 minutes (in 95% of patients), the effect lasts more than 24 hours. Against the background of treatment tolerance to the antihistamine effect of cetirizine does not develop. After cessation of treatment, the effect lasts up to 3 days.
Pharmacokinetics
The pharmacokinetic parameters of cetirizine vary linearly. Absorption After ingestion, the drug is rapidly and completely absorbed from the gastrointestinal tract. In adults, after a single dose of the drug in a therapeutic dose of Cmax in plasma is achieved after 1 ± 0.5 h and is 300 ng / ml.Taking the drug with food does not affect the amount of absorption. Distribution Cetirizine binds to plasma proteins by 93 ± 0.3%. Vd - 0.5 l / kg. When taking the drug in a dose of 10 mg for 10 days, cetirizine is not cumulated. Metabolism is metabolized in small quantities in the liver by O-dealkylation to form a pharmacologically inactive metabolite (unlike other histamine H1-receptor blockers in the liver with the participation of isoenzymes of the cytochrome P450 system). Excretion of T1 / 2 in adults is approximately 10 hours. Approximately 2/3 of the dose taken is excreted by the kidneys unchanged. Pharmacokinetics in special clinical situations T1 / 2 in children the age of 6-12 years - 6 hours; in children 2-6 years old - 5 hours; in children aged 6 months to 2 years - 3.1 hours. In elderly patients and patients with chronic liver diseases, a single dose of the drug in a dose of 10 mg T1 / 2 increases by about 50%, and the system clearance decreases by 40%. patients with mild renal failure (CK> 40 ml / min) pharmacokinetic parameters are similar to those in patients with normal renal function. In patients with moderately severe renal failure and in patients on hemodialysis (CK <7 ml / min), when taking the drug inside Pb 10 mg T1 / 2 is increased by 3 times, and the total clearance is reduced by 70% relative to patients with normal renal function, which requires a corresponding change mode dozirovaniya.Tsetirizin virtually eliminated from the body during hemodialysis.
Indications
Bronchogen is advisable to use for the prevention of bronchopulmonary diseases, especially in smokers and the elderly. The use of bronchogen increases the effectiveness of complex treatment of acute and chronic bronchitis, chronic bronchitis with an asthmatic component, smoker's bronchitis.
Contraindications
- terminal stage of renal failure (CC <10 ml / min); - pregnancy; - lactation period (breastfeeding); - hereditary intolerance to galactose, lactase deficiency or glucose-galactose malabsorption syndrome; - children under 6 years old (for pills); - children's age up to 6 months (for drops); - hypersensitivity to the drug components; - hypersensitivity to hydroxyzine. The drug should be prescribed with caution in chronic renal failure (correction of the dosage regimen is required), When chronic liver disease, elderly patients (due to a possible decrease in the glomerular filtration).
Precautionary measures
Before use, it is recommended to consult a doctor.
Use during pregnancy and lactation
Contraindicated in pregnancy. At the time of treatment should stop breastfeeding.
Dosage and administration
Inside, while eating. Adults - 1-2 caps. 1-2 times a day. Reception duration - 1 month. It is advisable to repeat the course in 4-6 months.
special instructions
Contraindicated in case of individual intolerance to the components, pregnancy, breastfeeding.