Antigrippine powder for solution. Chamomile 5g N10
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Active ingredients
Paracetamol + Chlorphenamine + Ascorbic Acid
Release form
Powder
Composition
Paracetamol 500 mg chlorophenamine maleate 10 mg ascorbic acid 200 mg. Auxiliary substances
Pharmacological effect
Combined drug. Paracetamol has an analgesic and antipyretic effect; eliminates headache and other types of pain, reduces fever nasal congestion, sneezing, tearing, itching and redness of the eyes
Pharmacokinetics
Paracetamol is rapidly and almost completely (95%) absorbed after peroral administration, peak concentrations in the blood plasma are reached 30-60 min after administration. Bioavailability is about 80%, binding to plasma proteins - 20%, half-life - 2-2.5 hours. Paracetamol is metabolized mainly in the liver, metabolites are excreted mainly in the urine. Chlorphenamine after oral administration is slowly absorbed from the gastrointestinal tract, the absorption level is 80%, peak concentrations in plasma are reached for 2.5-6 hours. The level of binding to plasma proteins is 45%. Chlorphenamine is predominantly metabolized in the liver, the unchanged drug and its metabolites are excreted by moistening, the half-life is 30 hours. Ascorbic acid is rapidly absorbed in the intestine. After suction, vitamin C quickly passes into the blood and is distributed to all tissues of the organism. The concentration of vitamin C in tissues and lymphocytes in tens of times exceeds its concentration in the blood plasma. Excretion is carried out with urine unchanged and in the form of metabolites. When ingested in physiological doses, oxalic acid (55%) is the main metabolite.
Indications
Infectious and inflammatory diseases (ARVI, influenza), accompanied by fever, chills, headache, pain in the joints and muscles, nasal congestion and sore throat and sinuses.
Contraindications
- hypersensitivity to paracetamol, ascorbic acid, chlorphenamine or any other component of the drug; - erosive and ulcerative lesions of the gastrointestinal tract (in the acute phase); - severe renal and / or hepatic insufficiency; - alcoholism; - angle-closure glaucoma; glands; - children's age up to 15 years; - pregnancy and lactation.
Precautionary measures
With care: renal and / or hepatic failure, deficiency of glucose-6-phosphate dehydrogenase, congenital hyperbilirubinemia (Gilbert, Dubin-Johnson and Rotor syndromes), viral hepatitis, alcoholic hepatitis, old age.
Use during pregnancy and lactation
Contraindicated in pregnancy and lactation.
Dosage and administration
Inside Adults and children over 15 years old - 1 sachet 2-3 times a day. The contents of the bag should be completely dissolved in a glass (200 ml) of warm water (50-60 ° C) and immediately drink the resulting solution. It is better to take the drug between meals. The maximum daily dose is 3 sachets. The interval between doses of the drug should be at least 4 hours. In patients with impaired liver or kidney function and in elderly patients, the interval between doses of the drug should be at least 8 hours. The duration of reception without consultation with a doctor is not more than 5 days when prescribed as an anesthetic. and 3 days as an antipyretic.
Side effects
The drug is well tolerated in the recommended doses. In isolated cases, there are: from the CNS: headache, fatigue, from the gastrointestinal tract: nausea, epigastric pain; from the endocrine system: hypoglycemia (up to the development of coma); from the blood-forming organs : anemia, hemolytic anemia (especially for patients with deficiency of glucose-6-phosphate dehydrogenase); extremely rare - thrombocytopenia, allergic reactions: skin rash, itching, urticaria, angioedema, anaphylactoid reactions (including anaphylactic shock), erythema multiforme exudative (including Stevens-Johnson syndrome), toxic epidermal necrolysis (syndrome Lyellas); other: hypervitaminosis C, metabolic disorders, sensation of heat, dry mouth, accommodation paresis, urinary retention, drowsiness.All side effects of the drug should be reported to the doctor.
Overdose
Symptoms of an overdose of the drug due to its constituent substances. The clinical picture of acute intoxication with paracetamol develops within 6-14 hours after its administration. Symptoms of chronic intoxication appear 2-4 days after overdose. Symptoms of acute intoxication with paracetamol: diarrhea, loss of appetite, nausea and vomiting, abdominal discomfort and / or abdominal pain, increased sweating. depression, convulsions. Treatment: symptomatic.
Interaction with other drugs
Ascorbic acid - increases the concentration in the blood of benzylpenicillin and tetracyclines; - improves the absorption in the intestines of iron preparations (converts trivalent iron to bivalent); can increase the excretion of iron with simultaneous use with deferoxamine - increases the risk of crystalluria in the treatment of short-acting salicylates and sulfonamides, slows the kidneys excretion of acids, increases the excretion of drugs with alkaline reactions (including alkaloids), reduces the concentration of oral contraceptives .- increases the overall clearance of ethanol; - with simultaneous use reduces the chronotropic effect of isoprenaline. It can both increase and decrease the effect of anticoagulant drugs. Reduces the effects of the anti-psychotic drugs. increase the risk of side effects (urinary retention, dry mouth, hard ry). Glucocorticosteroids - increase the risk of developing glaucoma. Ethanol enhances the sedative effect of chlorphenamine maleate. Paracetamol When paracetamol interacts with inducers of microsomal oxidation in the liver (phenytoin, ethanol, barbiturates, rifampicin, phenylbutazone,tricyclic antidepressants) increases the production of hydroxylated active metabolites, which makes it possible to develop severe intoxication with small overdose. On the background of paracetamol intake, ethanol contributes to the development of acute pancreatitis. paracetamol increases the concentration in the blood plasma of the latter by 50%, increasing hepatotoxicity. The simultaneous reception of barbiturates reduces the effectiveness of paracetamol. Paracetamol reduces the effectiveness of uricosuric drugs.
special instructions
When taking metoclopramide, domperidone or colestiramine, you should also consult with your doctor. With long-term use in doses much higher than recommended, the likelihood of impaired liver and kidney function increases, control of the peripheral blood picture is necessary. Paracetamol and ascorbic acid may distort laboratory test results plasma glucose and uric acid, bilirubin, activity of hepatic transaminases, LDH). In order to avoid toxic CONTROL liver paracetamol should not be combined with the admission of alcoholic beverages, as well as to make people prone to chronic alcohol consumption. The risk of liver damage increases in patients with alcoholic hepatosis. Appointment of ascorbic acid to patients with rapidly proliferating and intensely metastatic tumors may aggravate the process. In patients with a high content of iron in the body, ascorbic acid should be used in minimal doses. In one sachet of honey-lemon contains 1.793 g of sugar, which corresponds to 0.15 XE. In one sachet of chamomile contains 2.058 g of sugar, which corresponds to 0.17 XE.