Augmentin powder 125mg + 31.25mg 5ml 100ml
Condition: New product
1000 Items
Rating:
Be the first to write a review!
More info
Active ingredients
Amoxicillin + Clavulanic Acid
Release form
Powder
Composition
Powder for suspension for oral administration is white or almost white in color, with a characteristic odor. upon dilution, a suspension of white or almost white color is formed; on standing, a precipitate of white or almost white color slowly forms. 5 ml ready slurry. amoxicillin (in the form of trihydrate) 125 mg clavulanic acid (in the form of potassium salt) 31.25 mg Auxiliary substances: xanthan gum - 12.5 mg, aspartame - 12.5 mg, succinic acid - 0.84 mg, colloidal silicon dioxide - 25 mg, hypromellose - 150 mg, orange flavor 1 - 15 mg, orange flavor 2 - 11.25 mg, raspberry flavor - 22.5 mg, Bright Treacle flavor - 23.75 mg, silicon dioxide - 125 mg.
Pharmacological effect
Amoxicillin is a semi-synthetic broad-spectrum antibiotic that has activity against many gram-positive and gram-negative microorganisms. At the same time, amoxicillin is susceptible to destruction of.-Lactamases, and therefore the spectrum of amoxicillin activity does not extend to microorganisms that produce this enzyme. Clavulanic acid is an inhibitor of &. 946.-Lactamase, structurally related to penicillins, has the ability to inactivate a wide range of &. 946.-Lactamases found in microorganisms resistant to penicillins and cephalosporins. Clavulanic acid is sufficiently effective against plasmid & # 946.-Lactamase, which most often causes resistance of bacteria, and less effective against chromosomal & # 946.-Lactamase type 1, which are not inhibited by clavulanic acid. The presence of clavulanic acid in the Augmentin preparation. protects amoxicillin from destruction by enzymes - &. 946.-lactamases, which allows you to extend the antibacterial spectrum of amoxicillin. Below is the in vitro combination of amoxicillin with clavulanic acid. Bacteria usually sensitive to the combination of amoxicillin with clavulanic acid Gram-positive aerobes: Bacillus anthracis, Enterococcus faecalis, Listeria monocytogenes, Nocardia asteroides, Streptococcus pyogenes1,2, Streptococcus agalactiae1,2, Streptococcus spp. (other beta-hemolytic streptococci) 1,2, Staphylococcus aureus (sensitive to methicillin) 1, Staphylococcus saprophyticus (sensitive to methicillin), Staphylococcus spp. (coagulase-negative, methicillin-sensitive).Gram-negative aerobes: Bordetella pertussis, Haemophilus influenzae1, Helicobacter pylori, Moraxella catarrhalis1, Neisseria gonorrhoeae, Pasteurella multocida, Vibrio cholerae. Other: Borrelia burgdorferi, Leptospira icterohaemorrhagiae, Treponema pallidum. Gram-positive anaerobes: Clostridium spp., Peptococcus niger, Peptostreptococcus magnus, Peptostreptococcus micros, Peptostreptococcus spp. Gram-negative anaerobes: Bacteroides fragilis, Bacteroides spp., Capnocytophaga spp., Eikenella corrodens, Fusobacterium nucleatum, Fusobacterium spp., Porphyromonas spp., Prevotella spp. Bacteria that are likely to acquire resistance to the combination of amoxicillin with clavulanic acid Gram-negative aerobes: Escherichia coli1, Klebsiella oxytoca, Klebsiella pneumoniae1, Klebsiella spp., Proteus mirabilis, Proteus vulgaris, Proteus spp. Gram-positive aerobes: Corynebacterium spp., Enterococcus faecium, Streptococcus pneumoniae1,2, Streptococcus Viridans2 group. Bacteria with natural resistance to the combination of amoxicillin with clavulanic acid. enterocolitica. Other: Chlamydia pneumoniae, Chlamydia psittaci, Chlamydia spp., Coxiella burnetti, Mycoplasma spp. 1 - for these types of microorganisms, the clinical efficacy of the combination of amoxicillin with clavulanic acid was demonstrated in clinical studies. 2 - strains of these species of bacteria do not produce. # -46. Lactamase. Sensitivity with amoxicillin monotherapy suggests a similar sensitivity to the combination of amoxicillin with clavulanic acid.
Indications
Bacterial infections caused by susceptible microorganisms: - infections of the upper respiratory tract and ENT organs (for example, recurrent tonsillitis, sinusitis, otitis media), usually caused by Streptococcus pneumoniae, Haemophilus influenzae *, Moraxella catarrhalis *, Streptococcus pyogenes. - lower respiratory tract infections: exacerbations of chronic bronchitis, lobar pneumonia and bronchopneumonia, usually caused by Streptococcus pneumoniae, Haemophilus influenzae * and Moraxella catarrhalis * (except pills 250 mg / 125 mg). - infections of the urogenital tract: cystitis, urethritis, pyelonephritis, infections of the female genital organs, usually caused by species of the family Enterobacteriaceae (mainly Escherichia coli *), Staphylococcus saprophyticus and species of the genus Enterococcus. - gonorrhea caused by Neisseria gonorrhoeae * (except pills 250 mg / 125 mg). - infections of the skin and soft tissues, usually caused by Staphylococcus aureus *, Streptococcus pyogenes and species of the genus Bacteroides *. - infections of bones and joints: osteomyelitis, usually caused by Staphylococcus aureus *, with the need for long-term therapy. - odontogenic infections, such as periodontitis, maxillary sinusitis, severe dental abscesses with spreading cellulitis (for pills 500 mg / 125 mg or 875 mg / 125 mg). - other mixed infections (for example, septic abortion, postpartum sepsis, intra-abdominal sepsis) as part of step therapy (for pills of 250 mg / 125 mg or 500 mg / 125 mg, or 875 mg / 125 mg). * - some representatives of the specified kind of microorganisms produce &. 946.-lactamase, which makes them insensitive to amoxicillin.Infections caused by microorganisms susceptible to amoxicillin can be treated with Augmentin, since amoxicillin is one of its active ingredients. Drug Augmentin. also indicated for the treatment of mixed infections caused by amoxicillin-sensitive microorganisms, as well as microorganisms producing amoxicillin with clavulanic acid, which are sensitive to a combination of. The sensitivity of bacteria to the combination of amoxicillin with clavulanic acid varies depending on the region and over time. Where possible, local sensitivity data should be taken into account. If necessary, microbiological samples and bacteriological sensitivity analysis should be carried out.
Use during pregnancy and lactation
In reproductive studies in animals, oral and parenteral administration of the drug Augmentin. did not cause teratogenic effects. In a single study in women with premature rupture of the membranes, it was found that preventive drug therapy may be associated with an increased risk of necrotizing enterocolitis in the newborn. Like all drugs, Augmentin. It is not recommended to use during pregnancy, except in cases where the expected benefit to use for the mother outweighs the potential risk to the fetus. Drug Augmentin. can be used during breastfeeding. With the exception of the possibility of diarrhea or candidiasis of the mucous membranes of the oral cavity, associated with the penetration into the breast milk of trace amounts of the active ingredients of this drug, no other adverse effects were observed in breastfed babies. In the event of adverse effects in breastfed babies, breastfeeding should be discontinued.
Side effects
The adverse events listed below are listed in accordance with the damage to organs and organ systems and the frequency of occurrence. The frequency of occurrence is determined as follows: very often (& # 8805 .1 / 10), often (& # 8805 .1 / 100, <1/10), infrequently (& # 8805 .1 / 1000, <1/100), rarely (& # 8805 .1 / 10 000, <1/1000), very rarely (<1/10 000).Frequency categories were formed on the basis of clinical studies of the drug and post-registration observation. Infectious and parasitic diseases: often - candidiasis of the skin and mucous membranes. On the part of the blood and lymphatic system: rarely - reversible leukopenia (including neutropenia) and reversible thrombocytopenia. very rarely - reversible agranulocytosis and reversible hemolytic anemia, prolongation of prothrombin time and bleeding time, anemia, eosinophilia, thrombocytosis. On the part of the immune system: very rarely - angioedema, anaphylactic reactions, a syndrome similar to serum sickness, allergic vasculitis. On the part of the nervous system: infrequently - dizziness, headache. very rarely - reversible hyperactivity, convulsions (convulsions can be observed in patients with impaired renal function, as well as in those who receive high doses of the drug), insomnia, agitation, anxiety, behavior change. On the part of the gastrointestinal tract: adults: very often - diarrhea, often - nausea, vomiting. children - often - diarrhea, nausea, vomiting. the entire population: nausea is most often observed when taking high doses of the drug. If, after starting the drug, undesirable reactions from the gastrointestinal tract are observed, they can be eliminated if you take the drug at the beginning of the meal. Infrequently - digestive disorders. very rarely - antibiotic-associated colitis, induced by antibiotics (including pseudomembranous colitis and hemorrhagic colitis), black "hairy" tongue, gastritis, stomatitis. In children, when using the suspension, very rarely was a change in the color of the surface layer of the tooth enamel. Oral care helps to prevent discoloration of tooth enamel, as for this purpose it is enough to brush your teeth. Liver and biliary tract: infrequently - moderate increase in ACT and / or ALT activity (observed in patients receiving beta-lactam antibiotics, but its clinical significance is unknown). very rarely - hepatitis and cholestatic jaundice (these phenomena were observed during therapy with other penicillins and cephalosporins), an increase in the concentration of bilirubin and alkaline phosphatase. Adverse effects of the liver were observed mainly in men and elderly patients, and may be associated with long-term therapy.These adverse events are very rarely observed in children. These signs and symptoms usually occur during or immediately after the end of therapy, but in some cases they may not appear for several weeks after completion of therapy. Adverse events are usually reversible. Adverse effects on the part of the liver can be severe, in extremely rare cases there have been reports of deaths. In almost all cases, these were persons with severe comorbidities or persons receiving potentially potentially hepatotoxic drugs at the same time. On the part of the skin and subcutaneous tissues: rarely - rash, itching, urticaria. rarely erythema multiforme. very rarely - Stevens-Johnson syndrome, toxic epidermal necrolysis, bullous exfoliative dermatitis, acute generalized exantmatous pustus. In case of skin allergic reactions, treatment with Augmentin. need to stop. On the part of the kidneys and urinary tract: very rarely - interstitial nephritis, crystalluria, hematuria.
special instructions
The adverse events listed below are listed in accordance with the damage to organs and organ systems and the frequency of occurrence. The frequency of occurrence is determined as follows: very often (& # 8805 .1 / 10), often (& # 8805 .1 / 100, <1/10), infrequently (& # 8805 .1 / 1000, <1/100), rarely (& # 8805 .1 / 10 000, <1/1000), very rarely (<1/10 000). Frequency categories were formed on the basis of clinical studies of the drug and post-registration observation. Infectious and parasitic diseases: often - candidiasis of the skin and mucous membranes. On the part of the blood and lymphatic system: rarely - reversible leukopenia (including neutropenia) and reversible thrombocytopenia. very rarely - reversible agranulocytosis and reversible hemolytic anemia, prolongation of prothrombin time and bleeding time, anemia, eosinophilia, thrombocytosis. On the part of the immune system: very rarely - angioedema, anaphylactic reactions, a syndrome similar to serum sickness, allergic vasculitis. On the part of the nervous system: infrequently - dizziness, headache. very rarely - reversible hyperactivity, convulsions (convulsions can be observed in patients with impaired renal function, as well as in those who receive high doses of the drug), insomnia, agitation, anxiety, behavior change.On the part of the gastrointestinal tract: adults: very often - diarrhea, often - nausea, vomiting. children - often - diarrhea, nausea, vomiting. the entire population: nausea is most often observed when taking high doses of the drug. If, after starting the drug, undesirable reactions from the gastrointestinal tract are observed, they can be eliminated if you take the drug at the beginning of the meal. Infrequently - digestive disorders. very rarely - antibiotic-associated colitis, induced by antibiotics (including pseudomembranous colitis and hemorrhagic colitis), black "hairy" tongue, gastritis, stomatitis. In children, when using the suspension, very rarely was a change in the color of the surface layer of the tooth enamel. Oral care helps to prevent discoloration of tooth enamel, as for this purpose it is enough to brush your teeth. Liver and biliary tract: infrequently - moderate increase in ACT and / or ALT activity (observed in patients receiving beta-lactam antibiotics, but its clinical significance is unknown). very rarely - hepatitis and cholestatic jaundice (these phenomena were observed during therapy with other penicillins and cephalosporins), an increase in the concentration of bilirubin and alkaline phosphatase. Adverse effects of the liver were observed mainly in men and elderly patients, and may be associated with long-term therapy. These adverse events are very rarely observed in children. These signs and symptoms usually occur during or immediately after the end of therapy, but in some cases they may not appear for several weeks after completion of therapy. Adverse events are usually reversible. Adverse effects on the part of the liver can be severe, in extremely rare cases there have been reports of deaths. In almost all cases, these were persons with severe comorbidities or persons receiving potentially potentially hepatotoxic drugs at the same time. On the part of the skin and subcutaneous tissues: rarely - rash, itching, urticaria. rarely erythema multiforme. very rarely - Stevens-Johnson syndrome, toxic epidermal necrolysis, bullous exfoliative dermatitis, acute generalized exantmatous pustus.In case of skin allergic reactions, treatment with Augmentin. need to stop. On the part of the kidneys and urinary tract: very rarely - interstitial nephritis, crystalluria, hematuria.