Fluimucil effervescent pills 20 pcs
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Active ingredients
Acetylcysteine
Release form
Pills
Composition
Acetylcysteine 600 mg. Auxiliary substances: citric acid, sodium bicarbonate, aspartame, lemon flavor.
Pharmacological effect
Mucolytic drug. It dilutes sputum, increases its volume and facilitates its separation. The action of acetylcysteine is associated with the ability of its sulfhydryl groups to break intra- and intermolecular disulfide bonds of acid mucopolysaccharides of sputum, which leads to depolarization of mucoproteins and a decrease in the viscosity of sputum. Remains active in the presence of purulent sputum. Increases the secretion of less viscous sialomucins by goblet cells, reduces the adhesion of bacteria to the epithelial cells of the bronchial mucosa. Stimulates mucosal cells of the bronchi, the secret of which lyses fibrin. It has a similar effect on the secret produced in inflammatory diseases of the upper respiratory tract. It has an antioxidant effect, due to the presence of the SH-group, capable of neutralizing electrophilic oxidative toxins. Acetylcysteine easily penetrates into the cell, it is deacetylated to L-cysteine, from which intracellular glutathione is synthesized. Glutathione is a highly reactive tripeptide, a powerful antioxidant and cytoprotector that neutralizes endogenous and exogenous free radicals and toxins. Acetylcysteine prevents depletion and helps to increase the synthesis of intracellular glutathione, which is involved in the redox processes of cells, contributing to the detoxification of harmful substances. This explains the effect of acetylcysteine as an antidote for paracetamol poisoning. It protects alpha1-antitrypsin (an elastase inhibitor) from the inactivating effect of HOCL, an oxidizing agent produced by myeloperoxidase of active phagocytes. It also has an anti-inflammatory effect (due to the suppression of the formation of free radicals and active oxygen-containing substances responsible for the development of inflammation in the lung tissue).
Pharmacokinetics
Absorption: When ingestion is well absorbed from the gastrointestinal tract. After ingestion, Cmax in plasma is reached after 1-3 hours and is 15 mmol / l. Bioavailability is 10% due to the pronounced effect of "first pass" through the liver.Distribution: It penetrates into the extracellular space, mainly distributed in the liver, kidneys, lungs, bronchial secretions. It penetrates the placental barrier. Binding to plasma proteins - 50%. Metabolism: Deacetylated rapidly to cysteine in the liver. In plasma, there is a mobile equilibrium of free and plasma-bound acetylcysteine and its metabolites (cysteine, cystine, diacetylcystine). Excretion: T1 / 2 when administered orally is 1 hour, with cirrhosis of the liver increases to 8 hours. Excreted in the urine as inactive metabolites (inorganic sulfates, diacetylcysteine), a small part is excreted unchanged through the intestines.
Indications
- respiratory diseases, accompanied by disturbance sputum discharge (including bronchitis, tracheitis, bronchiolitis, pneumonia, bronchiectasis, cystic fibrosis, lung abscess, pulmonary emphysema, laryngotracheitis, interstitial lung disease, pulmonary atelectasis / occlusion due to bronchial mucus plug /) - catarrhal and purulent otitis, sinusitis, incl. sinusitis (to facilitate the secretion of secretions); - to remove viscous secretions from the respiratory tract in post-traumatic and postoperative conditions.
Contraindications
- gastric ulcer and duodenal ulcer in the acute phase; - lactation period; - children's age up to 2 years (for granules for preparing an oral solution); - children and adolescents up to 18 years (for effervescent pills); - hypersensitivity to acetylcysteine.; Use of the drug in the form of granules for preparation of the solution for ingestion in children under 2 years old is possible only if there are vital indications and with strict medical control.; With caution prescribed for ulcers of the stomach and dva tsatiperstnoy ulcers, oesophageal varices, hemoptysis, pulmonary hemorrhage, phenylketonuria, asthma, diseases of the adrenal gland, liver and / or renal insufficiency, arterial hypertension.
Dosage and administration
The drug in the form of effervescent pills prescribed to adults 600 mg (1 tab.) 1 time / day. Before use, the effervescent tablet is dissolved in 1/3 cup of water. Granules for the preparation of oral solution prescribed for adults and children over 6 years old - 200 mg 2-3 times / day; children aged 2 to 6 years - 200 mg 2 times / day or 100 mg 3 times / day; children aged 1 to 2 years, 100 mg 2 times / day. In newborns, the drug is used only for health reasons at a dose of 10 mg / kg body weight under the strict supervision of a physician.Before use, the required amount of granules is dissolved in 1/3 glass of water. Children of the first year of life are given to drink the resulting solution from a spoon or feeding bottle. The duration of treatment is set individually. In case of acute diseases, the duration of treatment is from 5 to 10 days, in case of chronic diseases - up to several months.