Hemomycin capsules 250 mg 6 pcs
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Active ingredients
Azithromycin
Release form
Capsules
Composition
1 capsule contains: Azithromycin dihydrate 262.03 mg, which corresponds to the content of azithromycin 250 mg. Additional substances: anhydrous lactose - 163.6 mg * (151.57 mg), corn starch - 47 mg, sodium lauryl sulfate - 0.94 mg, magnesium stearate - 8.46 mg. * Amount of lactate anhydrous depends on the activity of the active substance. The composition of the shell: titanium dioxide (E171) is 1.44 mg, the patented blue V (E131) dye is 0.0164 mg, and gelatin is up to 96 mg.
Pharmacological effect
Broad-spectrum antibiotic. Azithromycin is a representative of the macrolide antibiotic subgroup - azalides. It has a bactericidal effect in high concentrations. Hemomycin is active against aerobic gram-positive bacteria: Streptococcus pneumoniae, Streptococcus pyogenes, Streptococcus agalactiae, Streptococcus spp. groups C, F and G, Streptococcus viridans, Staphylococcus aureus; Aerobic Gram-negative bacteria: Haemophilus influenzae, Moraxella catarrhalis, Bordetella pertussis, Bordetella parapertussis, Legionella pneumophila, Haemophilus ducreyi, Helicobacter pylori, Campylobacter jejuni, Neisseria gonor rh o rr o syrhacrus, pylori pylori, neyseroslae neyserophylus pylori, Helicobacter pylori Anaerobic Bacterium
Pharmacokinetics
Asythromycin is rapidly absorbed from the gastrointestinal tract, due to its stability in an acidic environment and lipophilicity. After ingestion of Hemomycin in the dose of 500 mg of azithromycin Cmax in the blood plasma is achieved in 2.5-2.96 hours and is 0.4 mg / l. Bioavailability is 37%. DistributionAzithromycin penetrates well into the respiratory tract, organs and tissues of the urogenital tract, into the prostate gland, into the skin and soft tissues. High tissue concentrations (10–50 times higher than in plasma) and prolonged T1 / 2 are due to the low binding of azithromycin to plasma proteins, as well as its ability to penetrate into eukaryotic cells and concentrate in a low pH environment surrounding the lysosomes. This, in turn, determines a large apparent Vd (31.1 l / kg) and high plasma clearance. The ability of azithromycin to accumulate primarily in lysosomes is especially important for the elimination of intracellular pathogens. It has been proven that phagocytes deliver azithromycin to the site of infection, where it is released during phagocytosis. The concentration of azithromycin in the foci of infection is significantly higher than in healthy tissues (by an average of 24–34%) and correlates with the degree of inflammatory edema.Despite the high concentration in phagocytes, azithromycin does not significantly affect their function. Azithromycin remains in bactericidal concentrations in the inflammatory focus for 5-7 days after the last dose, which allowed developing short (3-day and 5-day) courses of treatment Metabolism In the liver, azithromycin is demethylated, the metabolites formed are inactive. Excretion Azithromycin is removed from blood plasma in 2 stages: T1 / 2 is 14-20 hours in the interval from 8 to 24 hours after taking the drug and 41 hours in the interval from 24 to 72 h, which allows you to use the drug 1 time / day.
Indications
Infectious and inflammatory diseases caused by microorganisms that are susceptible to the drug: - infections of the upper respiratory tract and ENT organs (tonsillitis, sinusitis, tonsillitis, otitis media), scarlet fever, lower infections of the respiratory tract (bacterial, including atypical pathogens, pneumonia, bronchitis); - infections of the urogenital tract (uncomplicated urethritis and / or cervicitis); - infections of the skin and soft tissues (erysipelas, impetigo, secondarily infected dermatosis); - Lyme disease (borreliosis) for the treatment of the initial stage (erythema migrans); - Diseases of the stomach and duodenum associated with Helicobacter pylori (as part of combination therapy) (for pills and capsules).
Contraindications
- liver failure; - renal failure; - children's age up to 12 years (for capsules and pills); - children's age up to 12 months (for a suspension of 200 mg / 5 ml); - children's age up to 6 months (for a suspension of 100 mg / 5 ml); - hypersensitivity to macrolide antibiotics.
Precautionary measures
The drug should be prescribed with caution during pregnancy, with arrhythmias (ventricular arrhythmias and prolongation of the QT interval are possible) in children with severe impaired liver function or kidney problems.
Use during pregnancy and lactation
In pregnancy, Hemomycin is prescribed only when the expected benefit of therapy for the mother outweighs the potential risk to the fetus. If necessary, use of the drug during lactation should decide whether to stop breastfeeding for the duration of the drug.
Dosage and administration
The drug is taken orally 1 time / day for 1 hour before meals or 2 hours after meals, becauseif taken with food, azithromycin absorption is reduced. If a single dose of a drug is missed, it should be taken as soon as possible, and subsequent doses - with an interval of 24 hours. Capsules An adult with upper and lower respiratory tract infections. Hemomycin is prescribed in 500 mg each (2 caps .) per day for 3 days; course dose - 1.5 g. In infections of the skin and soft tissues, 1 g (4 capsules) is prescribed on the 1st day, then 500 mg (2 capsules) daily from day 2 to day 5; course dose - 3 g. For acute uncomplicated urethritis or cervicitis, 1 g (4 capsules) is administered once. For Lyme disease (borreliosis), 1 g (4 capsules) is prescribed for the initial stage (erythema migrans) for the first day. and 500 mg (2 capsules) daily from the 2nd to the 5th day (course dose - 3 g). For diseases of the stomach and duodenum associated with Helicobacter pylori, 1 g (4 capsules) is prescribed per day for 3 days as part of combined anti-helicobacter therapy. Children over 12 years old with infections of the upper and lower respiratory tract, skin and soft tissues the drug is prescribed at the rate of 10 mg / kg 1 time / day for 3 days (course dose - 30 mg / kg) or on the first day - 10 mg / kg, then 4 days - 5-10 mg / kg / day. treatment of erythema migrans - 20 mg / kg on the first day and 10 mg / kg from day 2 to day 5.
Side effects
On the part of the digestive system: diarrhea (5%), nausea (3%), abdominal pain (3%); 1% or less - dyspepsia, vomiting, flatulence, melena, cholestatic jaundice, increased activity of liver enzymes, in children - constipation, anorexia, gastritis. On the side of the cardiovascular system: heartbeat, chest pain (1% or less). From the side of the central nervous system: dizziness, headache, vertigo, drowsiness; in children - headache (in the treatment of otitis media), hyperkinesia, anxiety, neurosis, sleep disturbance (1% or less). From the reproductive system: vaginal candidiasis. From the urinary system: nephritis (1% or less). Allergic reactions : rash, angioedema; children have conjunctivitis, pruritus, urticaria. Others: fatigue, photosensitization.
Overdose
Symptoms: nausea, temporary hearing loss, vomiting, diarrhea. Treatment: gastric lavage, conducting symptomatic therapy.
Interaction with other drugs
With simultaneous use of Hemomycin and antacids (aluminum and magnesium), azithromycin absorption is slowed down. Ethanol and food slow down and reduce azithromycin absorption. When co-administered with warfarin and azithromycin (in usual doses), no prothrombin time was detected, butthat the interaction of macrolides and warfarin may increase the anticoagulant effect, patients need careful control of prothrombin time. Combined use of azithromycin and digoxin increases the concentration of the latter. azithromycin reduces clearance and enhances the pharmacological action of triazolam. Azitromycin slows down ix and increases the plasma concentration and toxicity of cycloserine, anticoagulants, methylprednisolone, felodipine, as well as medicaments suffer from microsomal oxidation (carbamazepine, terfenadine, cyclosporine, hexobarbital, ergot alkaloids, valproate, disopyramide, bromocriptine, phenytoin, oral hypoglycemic agents, theophylline and other xanthine derivatives) - due to azithromycin inhibition of microsomal oxidation in hepatocytes. Linkosamines weaken the effectiveness of azithromic ina, and tetracycline and chloramphenicol increase. Pharmaceutical interaction Pharmaceutically azithromycin is incompatible with heparin.
special instructions
You should not take the drug during a meal. It is recommended that the interval of at least 2 hours between taking Hemomycin and antacid drugs. After discontinuation of treatment, some patients may persist hypersensitivity reactions, which requires specific therapy and medical control.