Kenalog 40 suspension 40 mg ml 1 ml 5 pcs
Condition: New product
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Description
Suspension for injection Kenalog in ampoules - glucocorticosteroid preparation for the treatment of rheumatoid arthritis, connective tissue diseases, systemic lupus erythematosus, dermatosis, pulmonary emphysema and pulmonary fibrosis, etc.
Active ingredients
Triamcinolone
Release form
Suspension
Composition
Triamcinolone 40mg / ml. Excipients: Carmellose sodium, sodium chloride, benzyl alcohol, polysorbate, water for injections.
Pharmacological effect
GKS. Suppresses the function of leukocytes and tissue macrophages. Limits the migration of leukocytes to the area of inflammation. Violates the ability of macrophages to phagocytosis, as well as the formation of interleukin-1. It contributes to the stabilization of lysosomal membranes, thereby reducing the concentration of proteolytic enzymes in the area of inflammation. Reduces capillary permeability due to histamine release. Suppresses the activity of fibroblasts and the formation of collagen. Inhibits the activity of phospholipase A2, which leads to the suppression of the synthesis of prostaglandins and leukotrienes. Suppresses the release of COX (mainly COX-2), which also helps to reduce the production of prostaglandins. Reduces the number of circulating lymphocytes (T-and B-cells), monocytes, eosinophils and basophils due to their movement from the vascular bed to the lymphoid tissue, inhibits the formation of antibodies. Suppresses the release of pituitary ACTH and? -Lipotropin, but does not reduce the level of circulating?-Endorphin. It inhibits the secretion of TSH and FSH. With the direct application of the vessels has a vasoconstrictor effect. It has a pronounced dose-dependent effect on the metabolism of carbohydrates, proteins and fats. Stimulates gluconeogenesis, promotes the uptake of amino acids by the liver and kidneys and increases the activity of gluconeogenesis enzymes. In the liver, it enhances the deposition of glycogen, stimulating the activity of glycogen synthetase and the synthesis of glucose from the products of protein metabolism. An increase in blood glucose activates insulin secretion. Inhibits glucose uptake by fat cells, which leads to activation of lipolysis. However, due to an increase in insulin secretion, lipogenesis is stimulated, which contributes to the accumulation of fat.It has a catabolic effect in the lymphoid and connective tissue, muscles, adipose tissue, skin, bone tissue. Osteoporosis and Itsenko-Cushing syndrome are the main factors limiting long-term therapy of corticosteroids. As a result of the catabolic effect, growth can be suppressed in children. In high doses, it can increase the excitability of brain tissue and contributes to lowering the threshold of convulsive readiness. Stimulates excessive production of hydrochloric acid and pepsin in the stomach, which contributes to the development of peptic ulcers. With systemic use, therapeutic activity is due to anti-inflammatory, anti-allergic, immunosuppressive and anti-proliferative effects. When applied topically and locally, the therapeutic activity of triamcinolone acetonide is due to the anti-inflammatory, antiallergic and anti-exudative (due to the vasoconstrictor effect) action. According to the anti-inflammatory activity of triamcinolone acetonide is 6 times more active than hydrocortisone. The mineralocorticoid activity of triamcinolone acetonide is practically absent.
Pharmacokinetics
With systemic use, it is metabolized mainly in the liver and partially in the kidneys. The main metabolic pathway is 6 -? - hydroxylation. T1 / 2 - 3.5 hours. Excreted by the kidneys.
Indications
For systemic use: bronchial asthma, chronic bronchitis with broncho-obstructive syndrome, pemphigoid, psoriasis, dermatitis. Intra-articular administration: chronic inflammatory diseases of the joints, exudative arthritis, gout, dropsy of the joints, blockade of the shoulder joint, chronic inflammation of the inner layer of the joint capsule. For external use: eczema, psoriasis, neurodermatitis, various types of dermatitis and other inflammatory and allergic skin diseases of non-microbial etiology (as part of complex therapy).
Contraindications
For systemic use: bronchial asthma, chronic bronchitis with broncho-obstructive syndrome, pemphigoid, psoriasis, dermatitis. Intra-articular administration: chronic inflammatory diseases of the joints, exudative arthritis, gout, dropsy of the joints, blockade of the shoulder joint, chronic inflammation of the inner layer of the joint capsule.For external use: eczema, psoriasis, neurodermatitis, various types of dermatitis and other inflammatory and allergic skin diseases of non-microbial etiology (as part of complex therapy).
Use during pregnancy and lactation
If necessary, use during pregnancy (especially in the first trimester) and during lactation should assess the intended benefits to the mother and the risk of side effects in the fetus or child.
Dosage and administration
Individual, depending on indications and the applied dosage form.
Side effects
For systemic use: bronchial asthma, chronic bronchitis with broncho-obstructive syndrome, pemphigoid, psoriasis, dermatitis. Intra-articular administration: chronic inflammatory diseases of the joints, exudative arthritis, gout, dropsy of the joints, blockade of the shoulder joint, chronic inflammation of the inner layer of the joint capsule. For external use: eczema, psoriasis, neurodermatitis, various types of dermatitis and other inflammatory and allergic skin diseases of non-microbial etiology (as part of complex therapy).
Interaction with other drugs
Individual, depending on indications and the applied dosage form.
special instructions
Not intended for on / in the introduction. With caution and under strict medical supervision used for edematous syndrome, obesity, mental illness and diseases of the gastrointestinal tract. During the period of treatment, it is recommended to take vitamin D and eat foods rich in calcium. When applied topically to prevent local infectious complications, it is recommended to be used in combination with antimicrobial agents. Parenteral use in children under the age of 6 years is not recommended, at the age of 6-12 years - under strict indications. Avoid prolonged external use in children, regardless of age.