Locoid curl emulsion 0.1% 30g
Condition: New product
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Description
Lokoid Krelo - glucocorticosteroid (GCS) for topical administration.
Active ingredients
Hydrocortisone 17-Butyrate
Release form
Emulsion
Composition
active ingredient: hydrocortisone 17-butyrate - 1 mg. auxiliary components: paraffin wax - 50 mg. soft white paraffin - 35 mg. cetostearyl alcohol - 20 mg. cetomacrogol 25-20 mg. borage oil - 17.5 mg. propylene glycol - 50 mg. butylhydroxytoluene - 0.2 mg. butyl parahydroxybenzoate - 1.5 mg. propyl parahydroxybenzoate - 3 mg. sodium citrate - 5 mg. citric acid - 6 mg. purified water - 790.8 mg.
Pharmacological effect
The active component of Loco Cretel - hydrocortisone butyrate, synthetic non-halogenated GCS. Due to the esterification of the hydrocortisone molecule with butyrate (butyric acid residue), the activity of the substance increases dramatically in comparison with native hydrocortisone, due to which Lokoid Krelo is a fast-acting drug with anti-inflammatory, anti-edematous, antipruritic effectiveness. When using hydrocortisone butyrate in recommended doses, suppression of the hypothalamic-pituitary-adrenal system does not occur. The consequence of its use in high doses for a long time, especially under occlusive dressings, can be an increase in plasma cortisol concentration, usually not accompanied by inhibition of reactivity of the pituitary-adrenal system. With the abolition of the drug, cortisol production quickly normalizes.
Pharmacokinetics
absorption: after application of the drug, the accumulation of the active substance occurs in the epidermis, mainly in the granular layer, its systemic absorption is insignificant. Hydrocortisone 17-butyrate in a small amount in unchanged form is absorbed into the systemic circulation. metabolism: hydrocortisone 17-butyrate is metabolized to hydrocortisone and other metabolites mostly directly in the epidermis and then in the liver.
Indications
According to the instructions, Lokoid Krelo is recommended for the treatment of such superficial, uninfected, sensitive to local GCS skin diseases such as dermatitis (including contact, atopic, seborrheic), psoriasis and eczema.
Contraindications
There are CONTRAINDICATIONS.BEFORE USE IT IS REQUIRED TO READ THE INSTRUCTIONS
Use during pregnancy and lactation
In connection with the ability of glucocorticoids to penetrate the placenta, and the possible effect on the development of the fetus, especially pronounced when applying Lokoid Krelo on large surfaces of the skin, the use of the drug during pregnancy is possible with special care, under the supervision of a doctor. Due to the lack of these quantitative indicators of hydrocortisone released in breast milk, it is necessary to prescribe the drug during lactation.
Dosage and administration
Emulsion Lokoid Crelou applied externally. On the affected areas the drug is applied with a light massaging movements with a thin layer 1-3 times a day. With the manifestation of positive dynamics, it is possible to reduce the multiplicity of application to 2-3 times per week. If necessary, after applying Lokida Krelo on the surface of foci with moistness, it is allowed to apply an occlusive dressing. The remaining emulsion from the treated surface is washed with water. The maximum weekly dose of the drug is 30–60 g (1–2 vials). Lokoid Krelo is recommended for the treatment of acute inflammation, especially in weeping areas. Also, this dosage form is optimally used for application to the affected skin with abundant hair, for example, on the hairy part of the scalp.
Side effects
Local reactions: irritation of the skin, in rare cases - other local reactions characteristic of GCS therapy. Systemic reactions: with prolonged use, application to large surfaces and / or the use of occlusive dressings, side effects characteristic of systemic GCS can be observed. The risk of local and systemic side effects when using Locoid Crelot is lower than when using fluorinated steroids.
Overdose
There is no data on Lokida Krelo's overdose. With prolonged use of the drug in high doses, it is possible to enhance the side effects described above. When symptoms of hypercortisolism appear, the drug should be withdrawn.
Interaction with other drugs
No data.
special instructions
Contraindications - bacterial infections of the skin (strepto-and staphyloderma, gram-negative folliculitis), - viral infections of the skin (herpes simplex,chicken pox, herpes zoster), - fungal infections of the skin, - tuberculosis and syphilitic skin lesions, - parasitic infections of the skin, - neoplastic skin changes (benign and malignant tumors), - acne, rosacea, perioral dermatitis, - post-vaccination period, - integrity integuments (wounds, ulcers), - hypersensitivity to the drug.
Storage conditions
In a cool dry place. Keep out of the reach of children. Do not expose to direct sunlight. At room temperature