Buy Neovir solution for intramuscular injection of ampoules 2 ml 5 pcs

Neovir solution for intramuscular injection of ampoules 2 ml 5 pcs

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Active ingredients

Sodium oxodihydroacridinyl acetate

Release form

Solution

Composition

Active ingredient: Oxodihydro-acridinyl sodium acetate (Oxodihydroacridinylacetate sodium) Active ingredient concentration (%): 12, 5

Pharmacological effect

Immunostimulating drug. It has antiviral activity against DNA and RNA genomic viruses. It has a pronounced anti-Chlamydia effect. The activity of the drug is associated with its ability to induce the formation of high titers of endogenous interferons in the body, especially interferon alfa. In V / m, administration of Neovir at a dose of 250 mg for detected serum concentrations of interferon is equivalent to the administration of 6–9 million IU of recombinant interferon alpha. Neovir activates bone stem cells brain, T lymphocytes and macrophages. Shows immunomodulating activity, normalizing the balance between subpopulations of T-helper and T-suppressor cells. In a number of diseases, Neovir is able to reduce the production of tumor necrosis factor in the body (HIV infection, herpes) and activate natural killer cells (in case of tumor diseases). Significantly increases the activity of polymorphonuclear leukocytes. In HIV infection, Neovir has an immunomodulating effect: it increases the absorptive activity of blood serum, increases the ability of leukocytes to synthesize interferon alpha, stimulates the formation of reactive oxygen species by phagocytes. The peak of interferon activity in the blood and tissues is observed several hours after Neovir and lasts for 16-20 hours

Pharmacokinetics

AbsorptionWith i / m administration, the bioavailability of Neovir is more than 90%. After administration of Neovir in a dose of 100-500 mg Cmax in the blood plasma is reached in 15-30 minutes and is 8.3 mcg / ml. After 5 hours, only insignificant concentrations of the active substance are determined, and after 6 hours, the drug is not detected in the blood plasma. After 15-30 minutes after administration of Neovir, serum interferon titers begin to increase in the plasma. Two peaks of interferon plasma levels were detected: 70 IU / ml in 1.5-2 hours and 110 IU / ml in 8-10 hours, after which they begin to decline. After 24 h, the concentration of serum interferon remains quite high, and returns to its original values ​​after 46-48 hours. Metabolism and excretion is not metabolized. T1 / 2 is 1 hour. It is excreted by the kidneys in unchanged form.

Indications

In the form of monotherapy or as part of complex therapy: - influenza and other acute respiratory viral diseases, including against the background of immunodeficiency states; - infections caused by the virus Herpes simplex, Varicella zoster, Herpes simplex genitalis, including those with impaired immune systems; - cytomegalovirus infection in persons with immunodeficiency; - radiation immunodeficiency; - HIV infection; - encephalitis and encephalomyelitis of viral etiology; - acute and chronic hepatitis B and C; - urethritis, epididymitis, prostatitis, cervicitis and salpingitis of chlamydial etiology; - venereal lymphogranuloma; - oncological diseases; - multiple sclerosis; - Candida lesions of the skin and mucous membranes; - human papillomavirus infection. Prevention of influenza and other acute respiratory viral diseases.

Contraindications

Individual intolerance to the drug. Severe kidney function (creatinine clearance less than 30 ml / min). Autoimmune diseases. Pregnancy and lactation, children under 18 years.

Precautionary measures

The clouding of the solution for injection to a milky white color indicates a violation of storage conditions and uselessness.

Use during pregnancy and lactation

The drug is contraindicated for use during pregnancy and lactation (breastfeeding).

Dosage and administration

The solution for injection is administered intramuscularly, a single therapeutic dose is 250 mg (1 ampoule) or 4-6 mg per kg of patient's body weight. If necessary, a single dose of the drug Neovir can be increased to 500 mg. The course of treatment, unless otherwise indicated, consists of 5-7 intramuscular injections of Neovir at a dose of 250 mg with an interval of 48 hours, the course dose depends on the clinical picture. Course duration 8–12 days. A single prophylactic dose is 250 mg (1 ampoule) or 4–6 mg per kg of body weight. With prolonged use, the recommended interval between injections of Neovir is 3–7 days. In HIV infection, Neovir solution for injections is used in combination with specific antiviral drugs. The course of treatment consists of 10 injections of 250 mg with an interval of 48 hours between injections. After the course, take a break of 2 months. Application of repeated courses according to indications is possible.

Side effects

In rare cases, you may experience an allergic reaction in the form of a rash on the skin. Possible low-grade fever, local rapidly passing pain at the injection site. In case of poor tolerance or soreness at the injection site, it is recommended to administer Neovir together with a local anesthetic solution (2 ml of a 0.25-0.5% solution of procaine).

Overdose

Data overdose Neovir not provided.

Interaction with other drugs

During clinical trials and use of the drug in clinical practice, there were no cases of incompatibility or potentiation of the drug when interacting with other drugs. There is no information about the physico-chemical incompatibility of Neovir with other drugs.

special instructions

In case of poor tolerance or pain in the place of intramuscular administration of the drug, it is recommended to administer Neovir together with 2 ml of a 0.25-0.5% novocaine solution.

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