Prednisone pills 5 mg 100 pcs
Condition: New product
993 Items
Rating:
Be the first to write a review!
More info
Description
Prednisolone inhibits the function of leukocytes and tissue macrophages. Limits the migration of leukocytes to the area of inflammation. Violates the ability of macrophages to phagocytosis, as well as the formation of interleukin-1. It contributes to the stabilization of lysosomal membranes, thereby reducing the concentration of proteolytic enzymes in the area of inflammation. Reduces capillary permeability due to histamine release. Suppresses the activity of fibroblasts and the formation of collagen. Inhibits the activity of phospholipase A2, which leads to the suppression of the synthesis of prostaglandins and leukotrienes. Suppresses the release of COX (mainly COX-2), which also helps to reduce the production of prostaglandins. Reduces the number of circulating lymphocytes (T-and B-cells), monocytes, eosinophils and basophils due to their movement from the vascular bed to the lymphoid tissue, inhibits the formation of antibodies. Prednisolone inhibits pituitary ACTH and β-lipotropin, but does not reduce the level of circulating β-endorphin. It inhibits the secretion of TSH and FSH. With the direct application of the vessels has a vasoconstrictor effect. Prednisolone has a pronounced dose-dependent effect on the metabolism of carbohydrates, proteins and fats. Stimulates gluconeogenesis, promotes the uptake of amino acids by the liver and kidneys and increases the activity of gluconeogenesis enzymes. In the liver, prednisone enhances the deposition of glycogen, stimulating the activity of glycogen synthetase and the synthesis of glucose from the products of protein metabolism. An increase in blood glucose activates the release of insulin. Prednisolone inhibits glucose uptake by fat cells, which leads to the activation of lipolysis. However, due to an increase in insulin secretion, lipogenesis is stimulated, which contributes to the accumulation of fat. It has a catabolic effect in the lymphoid and connective tissue, muscles, adipose tissue, skin, bone tissue. To a lesser extent than hydrocortisone, it affects the processes of water-electrolyte metabolism: it promotes the excretion of potassium and calcium ions, the retention of sodium and water ions in the body. Osteoporosis and Itsenko-Cushing syndrome are the main factors limiting long-term therapy of corticosteroids. As a result of the catabolic effect, growth can be suppressed in children.In high doses, prednisone can increase the excitability of brain tissue and contributes to lowering the threshold of convulsive readiness. It stimulates the excess production of hydrochloric acid and pepsin in the stomach, which leads to the development of peptic ulcers. With their systemic use, the therapeutic activity of prednisolone is due to anti-inflammatory, antiallergic, immunosuppressive and anti-proliferative effects. effect) action. Compared with hydrocortisone anti-inflammatory itelnaya activity of prednisolone four times more mineralocorticoid activity 0.6 times lower.
Active ingredients
Prednisolone
Release form
Pills
Composition
1 tablet contains: prednisone 5 mg, excipients: lactose monohydrate, silica, stearic acid, magnesium stearate, talc, povidone, corn starch, potato starch.
Pharmacological effect
Pharmacological action - anti-inflammatory, antiallergic, immunosuppressive, antipruritic, antiexudative. Like other glucocorticoids, it increases the synthesis of peptide inhibitors of phospholipase A2, reduces the level of PG, reduces the secretion of macrophage chemotactic factor, inhibits the migration of macrophages and lymphocytes into the center of inflammation, stabilizes the membranes of lysosomes (preventing the release of lysosomal enzymes), prevents the release of treatment of iffs from the treatment, and prevents the treatment of treatment by treatment of lysosomal enzymes), prevents the release of the treatment of iffs from the treatment of treatment of lysosomal enzymes), prevents the release of treatment of iffs from the treatment of treatment of the body by lysosomes, preventing the release of lysosomal enzymes, and prevents the release of the body count from the stimulation of lysosomes; and other biologically active substances.
Pharmacokinetics
When ingestion is well absorbed from the gastrointestinal tract. Cmax in plasma is noted after 90 min. In plasma, most of the prednisone is associated with transcortin (cortisol-binding globulin). Metabolized mainly in the liver. T1 / 2 is about 200 minutes. Excreted by the kidneys in unchanged form - 20%.
Indications
Allergies, contact dermatitis, adrenal glands shock.
Contraindications
Peptic ulcer and duodenal ulcer, Cushing's syndrome, osteoporosis, predisposition to thromboembolism, renal failure, severe arterial hypertension, chickenpox, simple and herpes zoster, vaccination period.
Precautionary measures
In children during the growth period, GCS should be used only according to absolute indications and under close medical supervision. Contraindications for external use: children's age (up to 2 years, with itching in the anus - up to 12 years).
Use during pregnancy and lactation
With extreme caution, especially in the first trimester of pregnancy, when breastfeeding, care should be taken if the child has hyperbilirubinemia.
Dosage and administration
Inside, without chewing and washing down with a small amount of liquid. The dose is selected individually. The appointment should take into account the circadian secretory rhythm of the GCS: most of the dose (2/3 dose) or the entire dose should be taken in the morning (about 8 am), and 1/3 in the evening. Treatment is stopped slowly, gradually reducing the dose. Adults: in acute conditions and as a replacement therapy, the initial daily dose is 20–30 mg, the supporting daily dose is 5–10 mg. If necessary, the initial daily dose can be 15–100 mg, supporting - 5–15 mg / day. For children: the initial daily dose is 1–2 mg / kg body weight and is divided into 4–6 doses, the supporting daily dose is 300–600 mcg / kg
Side effects
Gastrointestinal ulceration, hyperglycemia, diabetes mellitus, iatrogenic Cushing syndrome, arterial hypertension, osteoporosis, hypokalemia, insufficiency of the adrenal cortex, negative nitrogen balance, decrease in resistance to infections.
Overdose
Symptoms: increased side effects.
Interaction with other drugs
Barbiturates, speeding up the metabolism, weaken the effect. It reduces the effectiveness of oral hypoglycemic drugs, increases hypokalemia in the presence of diuretics, increases the risk of gastrointestinal bleeding when taking NSAIDs and anticoagulants.
special instructions
Use with caution in parasitic and infectious diseases of viral, fungal or bacterial nature (currently or recently transferred, including recent contact with a patient) - herpes simplex, herpes zoster (viraemic phase), chicken pox, measles, amebiasis, strongyloidosis (established or suspect), systemic mycosis, active and latent tuberculosis.Use in severe infectious diseases is permissible only against the background of specific therapy. Use with caution for 8 weeks before and 2 weeks after vaccination, for lymphadenitis after BCG vaccination, for immunodeficiency states (including AIDS or HIV infection). With caution used for gastrointestinal diseases: gastric ulcer and duodenal ulcer, esophagitis, gastritis, acute or latent peptic ulcer, newly created intestinal anastomosis, nonspecific ulcerative colitis with the threat of perforation or abs curing, diverticulitis. Use with caution in diseases of the cardiovascular system, incl. after a recent myocardial infarction (patients with acute and subacute myocardial infarction may spread necrosis, slow the formation of scar tissue and, as a result, rupture of the heart muscle), with decompensated chronic heart failure, hypertension, hyperlipidemia), with endocrine diseases - diabetes mellitus ( including violation of tolerance to carbohydrates), thyrotoxicosis, hypothyroidism, Itsenko-Cushing's disease, with severe chronic renal and / or liver failure, nephrourolithiasis, with hypoalbuminemia and conditions predisposing to its occurrence, with systemic osteoporosis, myasthenia, acute psychosis, obesity (III-IV degree), with polio (except for the form of bulbar encephalitis), open-and-closed-angle glaucoma. long) it is necessary to observe an oculist, control of blood pressure and water-electrolyte balance, as well as pictures of peripheral blood, blood glucose, in order to reduce side effects, you can assign anabolic steroids, antibiotics, and Chit intake of potassium in the body (diet, potassium supplements). It is recommended to clarify the need for administration of ACTH after a course of treatment with prednisone (after a skin test!). In Addison's disease, simultaneous use with barbiturates should be avoided. After discontinuation of treatment, withdrawal syndrome, adrenal insufficiency, and exacerbation of the disease, for which prednisone was prescribed, may occur. When intercurrent infections, septic conditions and tuberculosis, it is necessary to simultaneously conduct antibiotic therapy. In children during the period of growth of GCS should be imenyat only if absolutely indicated and under the close supervision of a physician.