Zofran rectal suppositories 16mg N1
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Active ingredients
Ondansetron
Release form
Suppositories
Composition
Plasma protein 4.5% -5.5%.
Pharmacological effect
Pharmacokinetics
Indications
Human Ig, reducing the lack of antibodies, reduces the risk of developing infections in patients with primary and secondary immunodeficiency.
Contraindications
In / in the drip. Before the introduction of the drug should be heated to room temperature or body temperature. You can only enter a clear solution. The initial infusion rate is 30 drops / min (1.65 ml / min), after 10 minutes the rate is increased to 40 drops / min (2.2 ml / min). Replacement therapy for primary and secondary immunodeficiencies (including children with AIDS): 0.1-0.4 g / kg with an interval of 1 month to increase the level of IgG. In the absence of a sufficient increase in the level of IgG or an excessively rapid decrease in the rate, the dose is increased to 0.8 g / kg or the time intervals between injections are reduced. Idiopathic thrombocytopenic purpura - 0.8-1 g / kg (if necessary, repeat the introduction on day 2 or 3) or 0.4 g / kg for 2-5 days. If necessary, repeat the course. Allogeneic bone marrow transplantation - 0.5 g / kg for 7 days. Kawasaki syndrome - 1.6-2 g / kg in several doses (within 2-5 days) or 2 g / kg in a single dose. For severe bacterial infections (including sepsis) and viral infections - 0.4–1 g / kg daily for 1–4 days. For the prevention of infections in premature infants with low birth weight - 0.5-1 g / kg with an interval of 1-2 weeks. With Guillain-Barre syndrome, chronic inflammatory demyelinating neuropathy - 0.4 g / kg for 5 days. If necessary, repeat the treatment at intervals of 4 weeks. In patients with coronary artery disease and cerebral ischemia, 0.4 g / kg daily is administered.
Use during pregnancy and lactation
A temporary increase in the content of antibodies administered in the patient's blood after the introduction of Ig may cause false-positive results of serological tests. Do not exceed the recommended rate of administration of the drug (probably the development of severe side effects). During the entire infusion period and 20 minutes after it, the patient must be under medical supervision.
Dosage and administration
Congenital immunodeficiency states (congenital full or partial immunodeficiency, variational immunodeficiency, severe combined immunodeficiency, Wiskott-Aldrich syndrome) idiopathic thrombocytopenic purpura (especially acute forms in children). Acquired immunodeficiency (chronic lymphocytic leukemia, AIDS in children, bone marrow transplantation, etc.types of transplantation) Kawasaki syndrome (as an adjunct to acetylsalicylic acid therapy) prevention and treatment of infectious diseases.
Side effects
Hypersensitivity, IgA deficiency in the presence of the patient's antibodies against IgA. With care: pregnancy, lactation.
special instructions
Hypersensitivity, IgA deficiency in the presence of the patient's antibodies against IgA. With care: pregnancy, lactation.