More info
Description
Composition Capsules P hard gelatin, size No0, blue. the contents of the capsules are a mixture of powder and granules of white or white with a creamy or pinkish tinge; lumps are allowed (10 pieces per pack). 1 caps paracetamol 360 mg. Excipients: pregelatinized starch - 9 mg, colloidal silicon dioxide - 3 mg, lactose monohydrate - 1.2 mg, magnesium stearate - 3.8 mg, polysorbate 80 - 3 mg. The composition of the hard gelatin capsule: gelatin - 94.795 mg, blue patented dye (E131) or diamond blue dye (E133) - 0.265 mg, titanium dioxide (E171) - 1.94 mg. P capsules are hard gelatinous, size No0, red. the contents of the capsules are a mixture of powder and granules from yellow to yellow with a greenish tint and white color, the presence of lumps is allowed (10 pieces per pack). 1 caps ascorbic acid 300 mg of calcium gluconate monohydrate 100 mg of rimantadine hydrochloride 50 mg of rutoside (as a trihydrate) 20 mg of loratadine 3 mg Excipients: potato starch - 2.2 mg, magnesium stearate - 4.8 mg. The composition of the hard gelatin capsule: gelatin - 94.064 mg, iron dye yellow oxide (E172) - 0.97 mg, iron dye red oxide (E172) - 0.485 mg, crimson dye [Ponzo 4R] (E124) - 0.511 mg, titanium dioxide (E171) - 0.97 mg. Pharmacological action Combined drug, has antiviral, interferonogenic, antipyretic, analgesic, antihistamine and angioprotective effect. Paracetamol has an analgesic and antipyretic effect. Ascorbic acid is involved in the regulation of redox processes, contributes to the normal permeability of capillaries, blood clotting, tissue regeneration, plays a positive role in the development of immune reactions of the body, compensates for vitamin C deficiency, prevents the development of increased permeability and fragility of blood vessels , causing hemorrhagic processes in influenza and acute respiratory viral infections, has antiallergic effect (mechanism is unclear). Rimantadine has antiviral activity against the influenza A virus. Blocking the M2 channels of the influenza A virus, impairs its ability to penetrate cells and release ribonucleoprotein, thereby inhibiting the most important stage of viral replication.Induces the production of interferon alpha and gamma. With influenza B virus, rimantadine has an antitoxic effect. Rutoside is an angioprotector. Reduces capillary permeability, swelling and inflammation, strengthens the vascular wall. It inhibits aggregation and increases the degree of red blood cell deformation. Loratadine, a blocker of histamine H1 receptors, prevents the development of tissue edema associated with the release of histamine.
Dosage and administration
: The drug is taken orally after a meal. Capsules should be washed down with water. The powder (contents of 1 sachet) must be dissolved in 1/2 cup of warm boiled water and stirred. The resulting solution should be consumed immediately after preparation. Adults are prescribed 1 capsule P blue and 1 capsule P red (single dose) or 1 sachet of powder 2-3 times / day. The drug should be taken within 3-5 days (no more than 5 days) until the symptoms of the disease disappear. In the absence of improvement in well-being, the patient should stop using the drug and consult a doctor. Precautions During the period of treatment may worsen psoriasis. With pheochromocytoma, propranolol can be used only after taking an alpha blocker. After a long course of treatment, propranolol should be discontinued gradually, under the supervision of a physician. Against the background of treatment with propranolol, IV administration of verapamil, diltiazem should be avoided. A few days before anesthesia, you must stop taking propranolol or pick up a remedy for anesthesia with minimal negative inotropic effects. Influence on the ability to drive vehicles and control mechanisms In patients whose activities require increased attention, the question of the use of propranolol on an outpatient basis should be addressed only after evaluating the individual response of the patient. Side effect On the part of the nervous system: irritability, drowsiness, tremor, hyperkinesia, dizziness, headache, "flush" of blood to the face. On the part of the digestive system: damage to the mucous membrane of the stomach and duodenum, dyspepsia, dry mucous membrane in the mouth, lack of appetite, flatulence, diarrhea. On the part of the urinary system: moderate pollakiuria. From the hemopoietic system: changes in blood parameters (control is needed).On the part of the endocrine system: inhibition of the function of the insular apparatus of the pancreas (hyperglycemia, glycosuria). Allergic reactions: skin rash, itching, urticaria. If any of the side effects indicated in the instructions are aggravated or any other side effects that are not indicated in the instructions are noted, the patient should immediately inform the doctor. Special instructions Duration of use - no more than 5 days. Do not use the drug in the presence of metastatic tumors. Patients who abuse alcohol should consult a physician before starting treatment with the drug, since paracetamol may have a damaging effect on the liver. Impact on the ability to drive vehicles and control mechanisms During the period of treatment, care must be taken when driving vehicles and doing other potentially hazardous activities that require high concentration of attention and speed of psychomotor reactions. Use during pregnancy and lactation. Use during pregnancy and during breastfeeding is contraindicated. Type: Medicinal product Amount in a package, pcs: 20 Shelf life: 24 months. Route of administration: Oral Vacation procedure: According to the prescription Release form: According to the recipe Storage conditions: In a dry place, In a sun-protected room, Keep away from children Maximum permissible storage temperature , ° C: 25 Pharmacological group: R05X Other combined drugs used for colds Minimum age: 18 yearsActive ingredients
Paracetamol + Rimantadine + Ascorbic Acid + Loratadine + Rutoside + Calcium Carbonate
Release form
Capsules
Composition
Capsules P solid gelatinous, size No0, blue. the contents of the capsules are a mixture of powder and granules of white or white with a creamy or pinkish tinge; lumps are allowed (10 pieces per pack). 1 caps paracetamol 360 mg. Excipients: pregelatinized starch - 9 mg, colloidal silicon dioxide - 3 mg, lactose monohydrate - 1.2 mg, magnesium stearate - 3.8 mg, polysorbate 80 - 3 mg. The composition of the hard gelatin capsule: gelatin - 94.795 mg, blue patented dye (E131) or diamond blue dye (E133) - 0.265 mg, titanium dioxide (E171) - 1.94 mg.P capsules are hard gelatinous, size No0, red. the contents of the capsules are a mixture of powder and granules from yellow to yellow with a greenish tint and white color, the presence of lumps is allowed (10 pieces per pack). 1 caps ascorbic acid 300 mg of calcium gluconate monohydrate 100 mg of rimantadine hydrochloride 50 mg of rutoside (as a trihydrate) 20 mg of loratadine 3 mg Excipients: potato starch - 2.2 mg, magnesium stearate - 4.8 mg. The composition of the hard gelatin capsule: gelatin - 94.064 mg, iron dye yellow oxide (E172) - 0.97 mg, iron dye red oxide (E172) - 0.485 mg, crimson dye [Ponzo 4R] (E124) - 0.511 mg, titanium dioxide (E171) - 0.97 mg.
Pharmacological effect
The combined drug has antiviral, interferonogenic, antipyretic, analgesic, antihistamine and angioprotective effects. Paracetamol has an analgesic and antipyretic effect. Ascorbic acid is involved in the regulation of redox processes, contributes to the normal permeability of capillaries, blood clotting, tissue regeneration, plays a positive role in the development of immune reactions of the body, compensates for vitamin C deficiency, prevents the development of increased permeability and fragility of blood vessels , causing hemorrhagic processes in influenza and acute respiratory viral infections, has antiallergic effect (mechanism is unclear). Rimantadine has antiviral activity against the influenza A virus. Blocking the M2 channels of the influenza A virus, impairs its ability to penetrate cells and release ribonucleoprotein, thereby inhibiting the most important stage of viral replication. Induces the production of interferon alpha and gamma. With influenza B virus, rimantadine has an antitoxic effect. Rutoside is an angioprotector. Reduces capillary permeability, swelling and inflammation, strengthens the vascular wall. It inhibits aggregation and increases the degree of red blood cell deformation. Loratadine, a blocker of histamine H1 receptors, prevents the development of tissue edema associated with the release of histamine.
Indications
- etiotropic treatment of influenza type A. - symptomatic treatment of "cold" diseases, influenza and ARVI, accompanied by fever, muscle pain, headache, chills in adults.
Contraindications
- Hypersensitivity to one or more components that make up the drug. - erosive and ulcerative lesions of the gastrointestinal tract in the acute phase. - gastrointestinal bleeding. - hemophilia. - hemorrhagic diathesis. - hypoprothrombinemia. - portal hypertension. - vitamin deficiency. - renal failure. - diseases of the thyroid gland. - acute diseases of the kidneys, liver (acute glomerulonephritis, acute pyelonephritis, acute hepatitis), or exacerbation of chronic diseases of these organs. - chronic alcoholism. - hypercalcemia, severe hypercalciuria. - Nephrourolithiasis. - sarcoidosis. - simultaneous reception of cardiac glycosides (risk of arrhythmias). - lactose intolerance, lactase deficiency, glucose-galactose malabsorption. - Phenylketonuria (for powder). - pregnancy. - breastfeeding period. - children's and teenage age up to 18 years. Precautions should use the drug and limit its use in epilepsy, cerebral arteriosclerosis, diabetes, deficiency of glucose-6-phosphate dehydrogenase deficiency, hemochromatosis, sideroblastic anemia, thalassemia, hyperoxaluria, kidney stones, dehydration, electrolyte disturbances (risk of hypercalcemia), diarrhea syndrome malabsorption, calcium nephrolourithiasis (in history), hypercalciuria. as well as in elderly patients with arterial hypertension (the risk of hemorrhagic stroke increases, due to rimantadine, which is part of the drug).
Use during pregnancy and lactation
Use during pregnancy and during breastfeeding is contraindicated.
Dosage and administration
The drug is taken orally after a meal. Capsules should be washed down with water. The powder (contents of 1 sachet) must be dissolved in 1/2 cup of warm boiled water and stirred. The resulting solution should be consumed immediately after preparation. Adults are prescribed 1 capsule P blue and 1 capsule P red (single dose) or 1 sachet of powder 2-3 times / day. The drug should be taken within 3-5 days (no more than 5 days) until the symptoms of the disease disappear. In the absence of improvement in well-being, the patient should stop using the drug and consult a doctor.
Side effects
On the part of the nervous system: irritability, drowsiness, tremor, hyperkinesia, dizziness, headache, flushing of the blood to the face. On the part of the digestive system: damage to the mucous membrane of the stomach and duodenum, dyspepsia, dry mucous membrane in the mouth, lack of appetite, flatulence, diarrhea. On the part of the urinary system: moderate pollakiuria. From the hemopoietic system: changes in blood parameters (control is needed). On the part of the endocrine system: inhibition of the function of the insular apparatus of the pancreas (hyperglycemia, glycosuria). Allergic reactions: skin rash, itching, urticaria. If any of the side effects indicated in the instructions are aggravated or any other side effects that are not indicated in the instructions are noted, the patient should immediately inform the doctor.
special instructions
On the part of the nervous system: irritability, drowsiness, tremor, hyperkinesia, dizziness, headache, flushing of the blood to the face. On the part of the digestive system: damage to the mucous membrane of the stomach and duodenum, dyspepsia, dry mucous membrane in the mouth, lack of appetite, flatulence, diarrhea. On the part of the urinary system: moderate pollakiuria. From the hemopoietic system: changes in blood parameters (control is needed). On the part of the endocrine system: inhibition of the function of the insular apparatus of the pancreas (hyperglycemia, glycosuria). Allergic reactions: skin rash, itching, urticaria. If any of the side effects indicated in the instructions are aggravated or any other side effects that are not indicated in the instructions are noted, the patient should immediately inform the doctor.