Cereton Capsules 400mg N28
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Active ingredients
Choline alfoscerat
Release form
Capsules
Composition
1 capsule contains: active substance: choline alfoscerate (in terms of 100% substance) 400 mg, excipients: glycerol, purified water, capsule composition: gelatin, sorbitol, glycerol, methyl parahydroxybenzoate, propyl parahydroxybenzoate, titanium dioxide, dye, ferric oxide, yellow, purified.
Pharmacological effect
Nootropic drug. Cholinomimetic central action, which contains 40.5% of metabolically protected choline. Metabolic protection contributes to the release of choline in the brain. Provides synthesis of acetylcholine and phosphatidylcholine in neuronal membranes, improves blood flow and enhances metabolic processes in the central nervous system, activates the reticular formation. Increases the linear blood flow rate on the side of traumatic brain damage, contributes to the normalization of the spatial and temporal characteristics of spontaneous bioelectric brain activity, regression of focal neurological symptoms and recovery of consciousness. It has a positive effect on the cognitive and behavioral reactions of patients with vascular diseases of the brain (dyscirculatory encephalopathy and residual cerebrovascular events). It has a preventive and corrective effect on the pathogenetic factors of involutional psychoorganic syndrome, changes the phospholipid composition of neuronal membranes and reduces cholinergic activity. Stimulates the dose-dependent release of acetylcholine under physiological conditions. Participating in the synthesis of phosphatidylcholine (membrane phospholipid), improves synaptic transmission, plasticity of neuronal membranes, receptor function. It does not affect the reproductive cycle and does not have a teratogenic, mutagenic effect.
Pharmacokinetics
Absorption and distribution: With parenteral administration, absorption is 88%, it easily penetrates the BBB (when taken orally, the concentration in the brain is 45% of that in plasma). It accumulates primarily in the brain, lungs and liver. Withdrawal: 85% of the drug in the form of carbon dioxide is excreted by the lungs, the rest (15%) is excreted by the kidneys and through the intestines.
Indications
Acute (injection) and recovery periods of severe TBI and ischemic stroke, recovery period of hemorrhagic stroke, occurring with focal hemispheric symptomatology or symptoms of a brain stem lesion. Psychoorganic syndrome in the background of degenerative and involutionary brain changes Cognitive disorders (mental functions, memory, confusion, disorientation, reduced motivation, initiative and ability to concentrate), including with dementia and encephalopathy. Old pseudomelancholia.
Contraindications
Hypersensitivity to the drug. The acute stage of hemorrhagic stroke. Pregnancy. Breastfeeding period. Children under 18 years (due to lack of data).
Precautionary measures
Cereton has no effect on the speed of psychomotor reactions.
Use during pregnancy and lactation
The drug is contraindicated in pregnancy and lactation (breastfeeding).
Dosage and administration
In the recovery period of traumatic brain injury, ischemic or hemorrhagic stroke, Cereton in the form of capsules is prescribed 800 mg in the morning and 400 mg in the afternoon for 6 months. In chronic cerebrovascular insufficiency and dementia syndromes, Cereton is prescribed 400 mg (1 capsule) 3 times a day, preferably after meals, for 3-6 months.
Side effects
Possible nausea (mainly as a result of dopaminergic activation), in this case, reduce the dose of the drug. Allergic reactions. Solution for injections , aggressiveness, anxiety, nervousness, cerebral ischemia, convulsions, dizziness. From the skin, rash, urticaria. Other pain at the injection site, increased urination.
Overdose
Symptoms: nausea. Treatment: conduct symptomatic therapy.
Interaction with other drugs
Clinically significant drug interactions drug Cereton with other drugs have been identified.
special instructions
Impact on the ability to drive vehicles and control mechanisms: Cereton has no effect on the speed of psychomotor reactions.