Diclofenac retard pills 100 mg 20 pcs
Condition: New product
1000 Items
Rating:
Be the first to write a review!
More info
Active ingredients
Diclofenac
Release form
Pills
Composition
1 tablet contains: Diclofenac 100 mg.
Pharmacological effect
NSAID, a derivative of phenylacetic acid. It has a pronounced anti-inflammatory, analgesic and moderate antipyretic effect. The mechanism of action is associated with inhibition of the activity of COX - the main enzyme in the metabolism of arachidonic acid, which is a precursor of prostaglandins, which play a major role in the pathogenesis of inflammation, pain and fever. The analgesic effect is due to two mechanisms: peripheral (indirectly, through suppression of prostaglandin synthesis) and central (due to inhibition of prostaglandin synthesis in the central and peripheral nervous system). as well as morning stiffness and swelling of the joints, contributes to an increase in range of motion. Reduces post-traumatic and postoperative pain, as well as inflammatory edema. Suppresses platelet aggregation. With long-term use has a desensitizing effect. When applied topically in ophthalmology, it reduces swelling and pain in inflammatory processes of non-infectious etiology.
Pharmacokinetics
After ingestion is absorbed from the gastrointestinal tract. Food intake slows down the rate of absorption, the degree of absorption does not change. About 50% of the active substance is metabolized during the first passage through the liver. When administered rectally, absorption is slower. The time to reach Cmax in the plasma after oral administration is 2-4 hours, depending on the dosage form used, after rectal administration - 1 hour, intramuscular injection - 20 minutes. The concentration of the active substance in the plasma is linearly dependent on the size of the applied dose. It does not accumulate. Plasma protein binding is 99.7% (mainly albumin). Penetrates into synovial fluid, Cmax is reached 2-4 hours later than in plasma. It is largely metabolized to form several metabolites, among which two are pharmacologically active, but less so than diclofenac. The systemic clearance of the active substance is approximately 263 ml / minT1 / 2 from plasma is 1-2 hours, from synovial fluid - 3-6 hours. Approximately 60% of the dose is excreted as metabolites by the kidneys, less than 1% is excreted in the urine unchanged, the rest is excreted in the form of metabolites with bile.
Indications
Articular syndrome (rheumatoid arthritis, arthrosis, ankylosing spondylitis, osteoarthritis, gout) pains in the spinal cord, neuralgia and pain syndrome, and inflammation after operations and traumatic necrosis inflammatory diseases (as an adjunct).
Contraindications
Erosive and ulcerative lesions of the gastrointestinal tract in the acute phase of aspirin triadobesity (III trimester) children's age and increased sensitivity to the drug.
Use during pregnancy and lactation
Use during pregnancy and lactation is possible in cases where the intended benefit to the mother outweighs the potential risk to the fetus or newborn.
Dosage and administration
Adults are prescribed 100 mg (1 retard tablet) 1 time per day with food.
Side effects
Possible: nausea, anorexia, flatulence, constipation, diarrhea, dizziness, headache, insomnia. Extremely rare: anemia, leukopenia, visual impairment, convulsions, abnormal liver function and / or kidney. In some cases: the occurrence of erosive and ulcerative lesions of the gastrointestinal tract.
Overdose
Currently no data available.
Interaction with other drugs
With simultaneous use of antihypertensive drugs with diclofenac, it is possible to weaken their action. There are isolated reports of convulsions in patients who took both NSAIDs and quinolone antibacterial drugs. When used simultaneously with GCS, the risk of side effects from the digestive system increases. may decrease diuretic effect. With simultaneous use with potassium-sparing diuretics, an increase in the concentration of potassium in the blood is possible. With simultaneous use with other NSAIDs, the risk of side effects may increase. There are reports of hypoglycemia or hyperglycemia in diabetic patients who used diclofenac along with hypoglycemic drugs. acetylsalicylic acid may decrease the concentration of diclofenac in the blood plasma. Although in clinical studies it is not established effects of diclofenac on the effect of anticoagulants,individual cases of bleeding with the simultaneous use of diclofenac and warfarin are described. With simultaneous use, it is possible to increase the concentration of digoxin, lithium and phenytoin in blood plasma. plasma concentrations of methotrexate and its increased toxicity. When used simultaneously, diclofenac may have no effect on bioavailability l morphine, however, the concentration of the active metabolite of morphine may remain elevated in the presence of diclofenac, which increases the risk of side effects of the morphine metabolite, including respiratory depression. When applied concurrently with pentazocine, a case of a large convulsive seizure is described; with rifampicin - perhaps a decrease in the concentration of diclofenac in the blood plasma; with ceftriaxone - the excretion of ceftriaxone with bile increases; with cyclosporine - possible increase in cyclosporine nephrotoxicity.
special instructions
It is used with extreme caution in case of liver, kidney, gastrointestinal tract history, dyspeptic symptoms, bronchial asthma, hypertension, heart failure, immediately after serious surgical interventions, as well as in elderly patients. With a history of allergic reactions to NSAIDs and sulfites Diclofenac is used only in emergency cases. In the course of treatment, systematic monitoring of liver and kidney function, and pictures of peripheral blood is necessary. Rectal administration is not recommended in patients with anorectal diseases or anorectal hemorrhages in history. Externally, it should be used only on intact skin areas. Diclofenac should be avoided in the eyes (except for eye drops) or on the mucous membranes. Patients using contact lenses should use eye drops no earlier than 5 minutes after removing the lenses. It is not recommended for use in children under 6 years of age. Alcohol is not recommended for systemic use during treatment with dosage forms. Effect on driving ability and control mechanismsIn the period of treatment may decrease the speed of psychomotor reactions. If visual clarity deteriorates after applying eye drops, you should not drive a car or engage in other potentially dangerous activities.