Duphalac syrup bottles 1000 ml
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Description
Duphalac syrup - a drug with a pronounced laxative effect.
Active ingredients
Lactulose
Release form
Syrup
Composition
Lactulose 66.7g. Excipients: purified water - up to 100 ml.
Pharmacological effect
Laxative. Causes a change in the flora of the colon (an increase in the number of lactobacilli), which leads to an increase in acidity in the lumen of the colon and stimulates its motility. Along with this, the volume increases and the softening of the feces occurs. As a result, a laxative effect develops, without direct influence on the mucous membrane and smooth muscles of the colon. Under the action of lactulose, ammonia is also absorbed in the colon, reducing the formation of nitrogen-containing toxic substances in its proximal section and, accordingly, their absorption into the vena cava system. It has the ability to inhibit the growth of Salmonella in the colon. Does not reduce the absorption of vitamins and is not addictive. Practically not absorbed from the intestines.
Pharmacokinetics
After ingestion lactulose by passage passes into the colon, where it is metabolized by bacteria that break down sugar. As a result, simple organic acids are formed — mainly lactic acid and, to a lesser extent, acetic and formic acid. A small amount of lactulose is absorbed and excreted in the urine unchanged.
Indications
Constipation, incl. chronic, during pregnancy, hemorrhoids, after surgical interventions on the colon and / or in the anus, to prepare for surgical interventions on the colon, to soften the stool (relief of defecation) in pain syndrome after removal of hemorrhoids, hepatic encephalopathy, hepatic precoma and coma.
Contraindications
Rectal bleeding, colo, ileostomy, suspected appendicitis, galactosemia, patients with lactose intolerance, lactase deficiency, glucose-galactose malabsorption, intestinal obstruction, hypersensitivity to lactulose.
Use during pregnancy and lactation
May be used during pregnancy and lactation (breastfeeding) according to indications.
Dosage and administration
The drug is intended for oral administration.The solution of lactulose can be taken both in diluted and undiluted form. It is necessary to immediately swallow the accepted single dose, without delaying the mouth. All dosages must be adjusted individually. In the case of a single daily dose, it must be taken at the same time, for example, during breakfast. During therapy with laxatives, it is recommended to take a sufficient amount of liquid (1.5-2 liters, which is 6-8 cups) per day. Dosage for treating constipation or to soften stools for medical purposes: The daily dose of lactulose can be taken once or by dividing it into two, using a measuring cup. The initial dose can be adjusted to a maintenance dose, depending on the response to taking the drug. The therapeutic effect may occur 2-3 days after the start of the drug. If the supporting daily dose is less than 15 ml, as well as for accurate dosing in children under 7 years of age it is recommended to use the drug in vials. Dose for the treatment of hepatic encephalopathy (adults). Initial dose: 3-4 times a day, 30-45 ml. Then they are transferred to an individually selected maintenance dose so that soft stools are maximally 2-3 times a day. The safety and efficacy of the drug in children (up to 18 years) with hepatic encephalopathy has not been established due to lack of data. Elderly patients and patients with renal or hepatic insufficiency. There are no special recommendations for dosing, since the systemic effect of lactulose is insignificant.
Side effects
On the part of the digestive system: in the first days of admission, meteorism may occur (usually gradually decreases and disappears), when taken in doses exceeding the recommended ones, abdominal pain and diarrhea are possible, which requires dose adjustment, rarely nausea. When used in high doses for a long time: for the prevention and treatment of hepatic precoma and coma, diarrhea and impaired water-electrolyte metabolism are possible. On the part of the nervous system: rarely - cramps, headache, dizziness. Other: possible - allergic reactions, rarely - arrhythmias, myalgia, fatigue, weakness.
Overdose
Symptoms: abdominal pain and diarrhea are possible when taking a very high dose.Treatment: stopping the drug or reducing the dose. In case of large fluid loss due to diarrhea or vomiting, correction of water-electrolyte imbalance may be required.
Interaction with other drugs
With simultaneous use with broad-spectrum antibiotics, it is possible to reduce the therapeutic efficacy of lactulose. With the simultaneous use of lactulose can disrupt the release of active substances from enteric preparations with a pH dependent release due to the fact that it lowers the pH of the intestinal contents.
special instructions
It should not be used for abdominal pain, nausea, vomiting without verification of the diagnosis. It is used with caution in patients with gastrocardiac syndrome. In such cases, treatment should begin with low doses and increase them gradually to avoid the development of flatulence. It is used with caution in patients with diabetes mellitus, especially in inflammatory lesions of the colon. With prolonged treatment (more than 6 months) should regularly monitor the level of potassium, chlorine and carbon dioxide in the blood plasma. If diarrhea occurs, lactulose should be discontinued.