Fromilid pills 250 mg 14 pcs
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Active ingredients
Clarithromycin
Release form
Pills
Composition
1 tab. clarithromycin 250 mg. Excipients: corn starch, microcrystalline cellulose (Avicel PH 101, Avicel PH 102), anhydrous colloidal silicon dioxide, pregelatinized starch, potassium polacrilin, talc, magnesium stearate.
Indications
Treatment of infectious and inflammatory diseases caused by pathogens that are susceptible to the drug, including: - infections of the upper respiratory tract (acute and chronic tonsillopharyngitis, acute and chronic recurrent sinusitis, acute otitis media) - infections of the lower respiratory tract (acute bacterial bronchitis , exacerbation of chronic bronchitis, community-acquired bacterial pneumonia, including pneumonia caused by atypical pathogens) - infections of the skin and soft tissues - infections caused by mycobacteria (Mycobacteri um avium complex, Mycobacterium kansasii, Mycobacterium marinum, Mycobacterium leprae) - prevention of the spread of infections caused by the Mycobacterium avium complex (MAC) in HIV-infected patients with a CD4 lymphocyte count (T-helper lymphocyte) of not more than 100 / mm3 - Helicobacterium-eradication in patients with duodenal ulcer or stomach ulcer (always in combination therapy).
Contraindications
- severe liver failure - hepatitis (in history) - porphyria - I trimester of pregnancy - lactation period - simultaneous therapy with terfenadine, cisapride, pimozide or astemizole - children up to 6 months (for the dosage form - granules for suspension for oral administration) - there is not enough experience regarding efficacy and safety of use - children under 12 years old and / or children weighing less than 33 kg (for the dosage form - film-coated pills) - congenital fructose intolerance, glucose / galactose malabsorption syndrome or deficiency of the enzyme sucrase-isomaltase (only for the dosage form - granules for the preparation of oral suspension) - hypersensitivity to the components of the drug - hypersensitivity to other macrolide antibiotics. The drug should be used with caution in patients with moderate to severe renal failure, with liver failure, in the second and third trimesters of pregnancy.
Dosage and administration
The drug is taken orally.Tablets should be swallowed whole, not breaking, with a small amount of liquid. Adults and children over the age of 12 years and / or with a body weight of> 33 kg are usually prescribed 250 mg every 12 hours. For the treatment of acute sinusitis, severe infections and in the case of infection caused by Haemophilus influenzae, 500 mg of clarithromycin is prescribed every 12 h. The course of treatment is 7-14 days. For the purpose of eradication of Helicobacter pylori, Fromilid is administered at a dose of 250-500 mg 2 times / day, usually within 7 days, in combination with other drugs. Children under the age of 12 years and / or with a body weight less than 33 kg are prescribed in the form of a suspension in a dose of 15 mg / kg body weight / day, divided into 2 doses. After taking the suspension, it is recommended to give the child some liquid to drink. The suspension contains tiny granules that should not be chewed, because their contents have a bitter taste. Included is a syringe for oral administration of the drug. One filled syringe holds 5 ml of a suspension containing 125 mg of clarithromycin. The syringe should be washed after each use. The dose of the drug for children is calculated based on the body weight of the child, as presented in the table. Body weight of the child Dose in ml (syringe) Dose in mg from 8 kg to 10 kg 2.5 -3 ml 2 times / day 62.5-75 mg from 10 kg to 12 kg 3-3.6 ml 2 times / day 75-90 mg from 12 kg to 14 kg 3.6-4.2 ml 2 times / day 90-105 mg from 14 kg to 16 kg 4.2-4.8 ml 2 times / day 105-120 mg from 16 kg to 18 kg 4.8-5.4 ml 2 times / day 120- 135 mg from 18 kg to 20 kg 5.4-6.0 ml 2 times / day 135-150 mg from 20 kg to 22 kg 6.0-6.6 ml 2 times / day 150-165 mg from 22 kg to 24 kg 6.6-7.2 ml 2 times / day 165-180 mg from 24 kg to 26 kg 7.2-7.8 ml 2 times / day 180-195 mg from 26 kg to 28 kg 7.8-8.4 ml 2 times / day 195-210 mg from 28 kg to 30 kg 8.4- 9.0 ml 2 times / day 210-225 mg from 30 kg to 33 kg 9.0-10 ml 2 times / day 250 mg The course of treatment usually lasts for 7-14 days d. For the treatment and prevention of the spread of the infection caused by the Mycobacterium avium complex, 500 mg is prescribed every 12 hours. The dose can be increased. The maximum daily dose is 2 g. For children, the drug is prescribed at a dose of 15 mg / kg / day, divided into 2 doses. The dose of the drug should not exceed 500 mg every 12 hours. The maximum daily dose recommended for children is 1 g. The treatment of an infection caused by the Mycobacterium avium complex is prolonged, the duration is 6 months or more. In patients with renal failure with a CC of less than 30 ml / min, or serum creatinine content of more than 290 mcmol / L (3.3 mg / dL), the dose should be reduced by 2 times or the interval between doses should be doubled. The maximum duration of treatment in patients of this group is 14 days.Terms of preparation of the suspension for oral administration To prepare the suspension, you need 42 ml of water. Pre-shake the vial to crumble the granules. Add 1/4 of the volume of water to the vial and shake until the granules dissolve. Add the rest of the water and shake well. The volume of the finished suspension should reach the line mark on the bottle.
Side effects
On the part of the digestive system: nausea, vomiting, diarrhea, abdominal pain, stomatitis, glossitis, short-term discoloration of teeth and tongue, pancreatitis, pseudomembranous enterocolitis, cholestatic jaundice, hepatitis. Impaired liver function can be severe, but usually reversible. Very rarely, cases of liver failure and death, mainly due to severe concomitant diseases and / or concomitant drug therapy. On the part of the central nervous system and peripheral nervous system: headache, vertigo, paresthesias, drowsiness, hallucinations, convulsions, psychosis, dizziness, confusion, fear, insomnia, nightmares, depersonalization, disorientation. From the hematopoietic system: leukopenia, neutropenia, thrombocytopenia. On the part of the senses: a change in taste (dysgeusia), smell, tinnitus, short-term hearing loss, taking place after discontinuation of the drug. Since the cardiovascular system: prolongation of the QT interval on the ECG, ventricular tachycardia of the "pirouette" type. On the part of the respiratory system: shortness of breath. From the musculoskeletal system: arthralgia, myalgia. On the part of the urinary system: interstitial nephritis, renal failure. Metabolism: hypoglycemia in patients taking hypoglycemic drugs. Allergic reactions: skin rash, urticaria, pruritus, swelling of the face, anaphylactic shock, Stevens-Johnson syndrome, toxic epidermal necrolysis (Lyell's syndrome), angioedema, angioedema. On the part of the blood coagulation system: unusual bleeding, hemorrhage. From the laboratory indicators: increased activity of hepatic transaminases and alkaline phosphatase, increased serum levels of bilirubin, creatinine, uric acid, prolongation of prothrombin time.Others: long-term use may develop cases of superinfection, candidiasis, resistance of microorganisms (pseudomembranous colitis, oral candidiasis).