Prednisolone ointment 0.5% 15g
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Active ingredients
Prednisolone
Release form
Ointment
Composition
Ointment for external use of 0.5% 1 g of prednisone 5 mg.
Contraindications
For short-term use for health reasons - increased sensitivity to prednisone. For intra-articular administration and administration directly to the lesion: previous arthroplasty, abnormal bleeding (endogenous or caused by the use of anticoagulants), intra-articular bone fracture, infectious (septic) inflammation in the joint and periarticular infections (including history), as well as general infectious disease, marked periarticular osteoporosis, no signs of inflammation in the joint ("dry" joint, for example, in osteoarthritis without synovitis), severe bone destruction and joint deformity (sharp narrowing of the joint space, ankylosis), joint instability as an outcome of arthritis, aseptic necrosis of the epiphysis of the bones forming the joint. For external use: bacterial, viral, fungal skin diseases, skin tuberculosis, skin manifestations of syphilis, skin tumors, post-vaccination period, violation of the integrity of the skin (ulcers, wounds), children (up to 2 years, with itching in the anus - up to 12 years), rosacea, acne vulgaris, perioral dermatitis. For use in ophthalmology: bacterial, viral, fungal diseases of the eye, tuberculous damage to the eyes, trachoma, violation of the integrity of the eye epithelium.
Use during pregnancy and lactation
When pregnancy (especially in the first trimester) is used only for health reasons. If necessary, use during lactation should carefully weigh the expected benefits of treatment for the mother and the risk to the child.
Side effects
On the part of the endocrine system: menstrual disorders, adrenal suppression, Itsenko-Cushing syndrome, suppression of the function of the pituitary-adrenal system, reduced carbohydrate tolerance, steroid diabetes or manifestation of latent diabetes, growth retardation in children, delayed sexual development in children. On the part of the digestive system: nausea, vomiting, steroid gastric and duodenal ulcers, pancreatitis, esophagitis, bleeding and perforation of the gastrointestinal tract, increased or decreased appetite, flatulence, hiccups. In rare cases - increased activity of hepatic transaminases and alkaline phosphatase.On the part of the metabolism: a negative nitrogenous balance due to protein catabolism, increased calcium excretion from the body, hypocalcemia, increased body weight, increased sweating. Since the cardiovascular system: loss of potassium, hypokalemic alkalosis, arrhythmia, bradycardia (up to cardiac arrest); steroid myopathy, heart failure (development or intensification of symptoms), ECG changes characteristic of hypokalemia, increased blood pressure, hypercoagulation, thrombosis. In patients with acute myocardial infarction - the spread of necrosis, slowing the formation of scar tissue, which can lead to rupture of the heart muscle. On the part of the musculoskeletal system: growth retardation and ossification processes in children (premature closure of the epiphyseal growth zones), osteoporosis (very rarely - pathological fractures, aseptic necrosis of the head of the humerus and femur), muscle tendon rupture, muscle weakness, steroid myopathy, reduction muscle mass (atrophy). On the part of the central nervous system: headache, increased intracranial pressure, delirium, disorientation, euphoria, hallucinations, manic-depressive psychosis, depression, nervousness or anxiety, insomnia, dizziness, vertigo, pseudotumor of the cerebellum, seizures. On the part of the organ of vision: posterior subcapsular cataract, increased intraocular pressure (with possible damage to the optic nerve), trophic changes of the cornea, exophthalmos, a tendency to develop a secondary infection (bacterial, fungal, viral). Dermatological reactions: petechiae, ecchymosis, thinning and brittleness of the skin, hyper- or hypopigmentation, acne, stria, tendency to the development of pyoderma and candidiasis. Reactions caused by immunosuppressive effects: slowing down the regeneration processes, reducing resistance to infections. When administered parenterally: in rare cases, anaphylactic and allergic reactions, hyper or hypopigmentation, atrophy of the skin and subcutaneous tissue, exacerbation after intrasynovial use, Charcot’s arthropathy, sterile abscesses, while injected into the nodules on the head - blindness.
Interaction with other drugs
With simultaneous use with salicylates may increase the likelihood of bleeding.With simultaneous use with diuretics may aggravate electrolyte disturbances. With simultaneous use with hypoglycemic drugs decreases the rate of decrease in blood glucose levels. With simultaneous use with cardiac glycosides increases the risk of glycosidic intoxication. With simultaneous use of rifampicin, the therapeutic effect of rifampicin may be reduced. With simultaneous use of antihypertensive drugs may reduce their effectiveness. With the simultaneous use of coumarin derivatives may weaken the anticoagulant effect. With the simultaneous use of rifampicin, phenytoin, barbiturates may weaken the effect of prednisolone. With the simultaneous use of hormonal contraceptives - enhancing the action of prednisone. With simultaneous use of acetylsalicylic acid may decrease the content of salicylates in the blood. With the simultaneous use of praziquantel may decrease its concentration in the blood. The emergence of hirsutism and acne contributes to the simultaneous use of other corticosteroids, androgens, estrogens, oral contraceptives and steroid anabolic steroids. The risk of developing cataracts is increased when antipsychotics, carbutamide and azathioprine are used against the background of GCS. The simultaneous appointment with m-holinoblokatorami (including antihistamines, tricyclic antidepressants), nitrates contributes to the development of increased intraocular pressure.
special instructions
Use with caution in parasitic and infectious diseases of viral, fungal or bacterial nature (currently or recently transferred, including recent contact with a patient) - herpes simplex, herpes zoster (viraemic phase), chicken pox, measles, amebiasis, strongyloidosis (established or suspect), systemic mycosis; active and latent tuberculosis. Use in severe infectious diseases is permissible only against the background of specific therapy. Use with caution for 8 weeks before and 2 weeks after vaccination, for lymphadenitis after BCG vaccination, for immunodeficiency states (including AIDS or HIV infection).Use with caution in diseases of the gastrointestinal tract: gastric ulcer and duodenal ulcer, esophagitis, gastritis, acute or latent peptic ulcer, a newly created intestinal anastomosis, ulcerative colitis with the threat of perforation or abscess formation, diverticulitis. Use with caution in diseases of the cardiovascular system, incl. after a recent myocardial infarction (patients with acute and subacute myocardial infarction may spread necrosis, slow the formation of scar tissue and, as a result, rupture of the heart muscle), with decompensated chronic heart failure, hypertension, hyperlipidemia), with endocrine diseases - diabetes mellitus ( including violation of tolerance to carbohydrates), thyrotoxicosis, hypothyroidism, Itsenko-Cushing's disease, with severe chronic renal and / or liver failure, nephrourolithiasis, with hypoalbuminemia and conditions predisposing to its occurrence, with systemic osteoporosis, myasthenia, acute psychosis, obesity (III-IV degree), with poliomyelitis (except for the form of bulbar encephalitis), open-and-close-angle glaucoma. If necessary, intra-articular administration should be used with caution in patients with a general serious condition, inefficiency (or short duration) of the effect of 2 previous injections (taking into account the individual properties of the used GCS). During treatment (especially long-term), it is necessary to observe an oculist, control of blood pressure and water-electrolyte balance, as well as a picture of peripheral blood, blood glucose; In order to reduce side effects, you can assign anabolic steroids, antibiotics, as well as increase potassium intake (diet, potassium supplements). It is recommended to clarify the need for the introduction of ACTH after a course of treatment with prednisone (after conducting a skin test!). In Addison's disease, concurrent use with barbiturates should be avoided. After discontinuation of treatment, the onset of withdrawal syndrome, adrenal insufficiency, as well as exacerbation of the disease, for which prednisone was prescribed, may occur. For intercurrent infections, septic conditions and tuberculosis, simultaneous antibiotic therapy is necessary.In children during the growth period, GCS should be used only when absolutely indicated and under close medical supervision. Outwardly should not be used for more than 14 days. In case of use in case of common or pink acne, an exacerbation of the disease is possible.