Verapamil-Ozone film-coated pills 40mg N50

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Description

Composition of Verapamil Hydrochloride 40 mg Pharmacological action Selective calcium channel blocker class I, a derivative of diphenylalkylamine. It has antianginal, antiarrhythmic and antihypertensive effects. Antianginal effect is associated with a direct effect on the myocardium, and with the effect on peripheral hemodynamics (reduces the tone of peripheral arteries, OPSS). The blockade of calcium in the cell leads to a decrease in the transformation of ATP energy contained in high-energy bonds into mechanical work, a decrease in myocardial contractility. Decreases myocardial oxygen demand, has a vasodilating, negative and chronotropic effect. Increases the period of diastolic relaxation of the left ventricle, reduces the tone of the myocardial wall. The decrease in OPSS may also be due to the antihypertensive effect of verapamil. Verapamil significantly reduces AV conductivity, lengthens the period of refractoriness and suppresses the automatism of the sinus node. It has antiarrhythmic effect in supraventricular arrhythmias.

Dosage and administration

Individual. Inside adults - in the initial dose of 40-80 mg 3 times / day. For dosage forms of prolonged action, a single dose should be increased, and the frequency of administration should be reduced. Children aged 6-14 years - 80-360 mg / day, up to 6 years - 40-60 mg / day. reception frequency - 3-4 times / day. If necessary, verapamil can be administered intravenously (slowly, under the control of blood pressure, heart rate, and ECG). A single dose for adults is 5-10 mg, in the absence of effect after 20 minutes it is possible to re-enter in the same dose. A single dose for children aged 6-14 years is 2.5-3.5 mg, 1-5 years - 2-3 mg, up to 1 year - 0.75-2 mg. For patients with severely impaired liver function, the daily dose of verapamil should not exceed 120 mg. The maximum daily intake for adults when administered is 480 mg. Precautions During the period of treatment may worsen psoriasis. With pheochromocytoma, propranolol can be used only after taking an alpha blocker. After a long course of treatment, propranolol should be discontinued gradually, under the supervision of a physician. Against the background of treatment with propranolol, IV administration of verapamil, diltiazem should be avoided. A few days before anesthesia, you must stop taking propranolol or pick up a remedy for anesthesia with minimal negative inotropic effects.Influence on the ability to drive vehicles and control mechanisms In patients whose activities require increased attention, the question of the use of propranolol on an outpatient basis should be addressed only after evaluating the individual response of the patient. Side effect From the side of the cardiovascular system: bradycardia (less than 50 beats / min), pronounced decrease in blood pressure, development or aggravation of heart failure, tachycardia. rarely - angina, up to the development of myocardial infarction (especially in patients with severe obstructive damage to the coronary arteries), arrhythmia (including flicker and ventricular flutter). with a rapid on / in the introduction - AV-blockade III degree, asystole, collapse. On the part of the central nervous system and peripheral nervous system: dizziness, headache, fainting, anxiety, lethargy, increased fatigue, asthenia, drowsiness, depression, extrapyramidal disorders (ataxia, mask-like face, shuffling gait, stiffness of arms or legs, trembling hands and fingers, difficulty swallowing). On the part of the digestive system: nausea, constipation (rarely - diarrhea), gingival hyperplasia (bleeding, soreness, swelling), increased appetite, increased activity of hepatic transaminases and alkaline phosphatase. Allergic reactions: pruritus, skin rash, flushing of the skin of the face, erythema multiforme exudative (including Stevens-Johnson syndrome). Others: weight gain, very rarely - agranulocytosis, gynecomastia, hyperprolactinemia, galactorrhea, arthritis, transient vision loss on the background of maximum plasma concentration (with intravenous administration), pulmonary edema, asymptomatic thrombocytopenia, peripheral edema. Cautions C caution should be used for AV-blockade of I degree, bradycardia, severe stenosis of the aortic mouth, chronic heart failure, with mild or moderate arterial hypotension, in the acute phase of myocardial infarction, obstructive hypertrophic cardiomyopathy, with hepatic and / or renal failure, elderly patients, in children and adolescents under the age of 18 years (the efficacy and safety of use have not been studied). If necessary, combination therapy of angina and arterial hypertension with verapamil and beta-blockers is possible. However, it should be avoided in / in the introduction of beta-blockers against the background of the use of verapamil.Impact on the ability to drive vehicles and control mechanisms After taking verapamil, individual reactions (drowsiness, dizziness) are possible, affecting the patient's ability to perform work that requires high concentration of attention and speed of psychomotor reactions. Use during pregnancy and lactation Verapamil is contraindicated during pregnancy and lactation. Type: Drug Quantity in the package, pcs: 50 Shelf life: 24 months Active ingredient: Verapamil (Verapamil) Route of administration: Oral Vacation procedure: Prescription Product form: Prescription Storage conditions: In a dry place, In a dark place, Keep out of reach of children Maximum storage temperature, ° С: 25 Pharmacological group: C08DA01 Verapamil Minimum age: 18 years

Active ingredients

Verapamil

Release form

Pills

Composition

Verapamil hydrochloride 40 mg

Pharmacological effect

A selective class I calcium channel blocker, a derivative of diphenylalkylamine. It has antianginal, antiarrhythmic and antihypertensive effects. Antianginal effect is associated with a direct effect on the myocardium, and with the effect on peripheral hemodynamics (reduces the tone of peripheral arteries, OPSS). The blockade of calcium in the cell leads to a decrease in the transformation of ATP energy contained in high-energy bonds into mechanical work, a decrease in myocardial contractility. Decreases myocardial oxygen demand, has a vasodilating, negative and chronotropic effect. Increases the period of diastolic relaxation of the left ventricle, reduces the tone of the myocardial wall. The decrease in OPSS may also be due to the antihypertensive effect of verapamil. Verapamil significantly reduces AV conductivity, lengthens the period of refractoriness and suppresses the automatism of the sinus node. It has antiarrhythmic effect in supraventricular arrhythmias.

Indications

Treatment and prevention of coronary artery disease: chronic stable angina (exertional angina), unstable angina, vasospastic angina (Prinzmetal angina / variant angina). Treatment and prevention of cardiac arrhythmias: paroxysmal supraventricular tachycardia, chronic atrial flutter and atrial fibrillation (tachyarrhythmic variant), supraventricular extrasystole.Arterial hypertension. Hypertensive crisis. Hypertrophic Cardiomyopathy

Contraindications

Cardiogenic shock, heart failure, marked impairment of the contractile function of the left ventricle, severe hypotension (systolic blood pressure less than 90 mm Hg), bradycardia. SSS, sinoatrial block, AV block II and III degrees (except for patients with a pacemaker). atrial flutter and atrial fibrillation in combination with WPW-syndrome or Laun-Ganng-Levine syndrome (except for patients with a pacemaker). simultaneous administration with colchicine, dantrolene, aliskiren, sertindole. pregnancy, lactation (breastfeeding). hypersensitivity to verapamil.

Use during pregnancy and lactation

Verapamil is contraindicated during pregnancy and lactation.

Dosage and administration

Individual. Inside adults - in the initial dose of 40-80 mg 3 times / day. For dosage forms of prolonged action, a single dose should be increased, and the frequency of administration should be reduced. Children aged 6-14 years - 80-360 mg / day, up to 6 years - 40-60 mg / day. reception frequency - 3-4 times / day. If necessary, verapamil can be administered intravenously (slowly, under the control of blood pressure, heart rate, and ECG). A single dose for adults is 5-10 mg, in the absence of effect after 20 minutes it is possible to re-enter in the same dose. A single dose for children aged 6-14 years is 2.5-3.5 mg, 1-5 years - 2-3 mg, up to 1 year - 0.75-2 mg. For patients with severely impaired liver function, the daily dose of verapamil should not exceed 120 mg. The maximum daily intake for adults when administered is 480 mg.

Side effects

Since the cardiovascular system: bradycardia (less than 50 beats./min), a pronounced decrease in blood pressure, the development or aggravation of heart failure, tachycardia. rarely - angina, up to the development of myocardial infarction (especially in patients with severe obstructive damage to the coronary arteries), arrhythmia (including flicker and ventricular flutter). with a rapid on / in the introduction - AV-blockade III degree, asystole, collapse. On the part of the central nervous system and peripheral nervous system: dizziness, headache, fainting, anxiety, lethargy, increased fatigue, asthenia, drowsiness, depression, extrapyramidal disorders (ataxia, mask-like face, shuffling gait, stiffness of arms or legs, trembling hands and fingers, difficulty swallowing).On the part of the digestive system: nausea, constipation (rarely - diarrhea), gingival hyperplasia (bleeding, soreness, swelling), increased appetite, increased activity of hepatic transaminases and alkaline phosphatase. Allergic reactions: pruritus, skin rash, flushing of the skin of the face, erythema multiforme exudative (including Stevens-Johnson syndrome). Others: weight gain, very rarely - agranulocytosis, gynecomastia, hyperprolactinemia, galactorrhea, arthritis, transient vision loss on the background of maximum plasma concentration (with intravenous administration), pulmonary edema, asymptomatic thrombocytopenia, peripheral edema.

special instructions

Since the cardiovascular system: bradycardia (less than 50 beats./min), a pronounced decrease in blood pressure, the development or aggravation of heart failure, tachycardia. rarely - angina, up to the development of myocardial infarction (especially in patients with severe obstructive damage to the coronary arteries), arrhythmia (including flicker and ventricular flutter). with a rapid on / in the introduction - AV-blockade III degree, asystole, collapse. On the part of the central nervous system and peripheral nervous system: dizziness, headache, fainting, anxiety, lethargy, increased fatigue, asthenia, drowsiness, depression, extrapyramidal disorders (ataxia, mask-like face, shuffling gait, stiffness of arms or legs, trembling hands and fingers, difficulty swallowing). On the part of the digestive system: nausea, constipation (rarely - diarrhea), gingival hyperplasia (bleeding, soreness, swelling), increased appetite, increased activity of hepatic transaminases and alkaline phosphatase. Allergic reactions: pruritus, skin rash, flushing of the skin of the face, erythema multiforme exudative (including Stevens-Johnson syndrome). Others: weight gain, very rarely - agranulocytosis, gynecomastia, hyperprolactinemia, galactorrhea, arthritis, transient vision loss on the background of maximum plasma concentration (with intravenous administration), pulmonary edema, asymptomatic thrombocytopenia, peripheral edema.

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