Cerepro Capsules 400mg N28
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Description
Cerepro capsules are a nootropic drug. The drug improves brain function by acting on the pathogenetic factors of involutional psychoorganic syndrome, changes the phospholipid composition of neuronal membranes and reduces cholinergic activity.
Active ingredients
Choline alfoscerat
Composition
Choline alfoscerate (glycerylphosphorylcholine hydrate) 400 mg, glycerol (glycerin), purified water. Capsule shell composition: medical gelatin, glycerol (glycerol), methyl parahydroxybenzoate (methyl paraben), propyl parahydroxybenzoate (propyl parabenobropane), and I am using this option. sorbitol (sorbitol).
Pharmacological effect
Cholinomimetic central action, which contains 40.5% of metabolically protected choline (metabolic protection contributes to the release of choline in the brain). When ingested, it is broken down by the action of enzymes on choline and glycerophosphate: choline is involved in the biosynthesis of acetylcholine, one of the main mediators of nervous excitation, glycerophosphate is a precursor of the phospholipids (phosphatidylcholine) of the neural membrane. The drug provides the synthesis of acetylcholine and phosphatidylcholine in neuronal membranes, improves blood flow and enhances metabolic processes in the CNS, activates the reticular formation, increases the linear blood flow rate on the side of the traumatic brain damage, helps normalize the spatial and temporal characteristics of spontaneous bioelectric activity of the brain, has a positive effect on cognitive and behavioral reactions of patients with vascular diseases of the brain. The drug improves the function the brain, by acting on the pathogenetic factors of involutional psychoorganic syndrome, changes the phospholipid composition of neuronal membranes and reduces cholinergic activity. Dose-dependent stimulates the release of acetylcholine, participating in the synthesis of phosphatidylcholine (membrane phospholipid), improves synaptic transmission, plasticity of neuronal membranes, the function of receptors.
Pharmacokinetics
After ingestion, the absorption is 88%. It easily penetrates the BBB, the concentration in the brain reaches 45% level in the blood plasma. In the body of choline alfoscerate, under the action of enzymes biotransformed to choline and glycerol phosphate (which ensures the pharmacological effects of the drug). 85% is excreted by the lungs in the form of carbon dioxide, the rest (15%) is excreted through urine and feces.
Indications
- acute and recovery periods of severe traumatic brain injury and ischemic stroke, recovery period of hemorrhagic stroke, occurring with focal hemispheric symptomatology or symptoms of a brain stem lesion, - psychoorganic syndrome with degenerative and involutionary changes in the brain, chronic insufficiency of cerebral circulation, - cognitive insufficiency of cerebral circulation, - chronic cerebral circulatory insufficiency, - cognitive insufficiency of cerebral circulation, - chronic cerebral circulation insufficiency, - cognitive insufficiency of cerebral circulation, - chronic cerebral circulatory insufficiency, - cognitive insufficiency of cerebral circulation, cerebral insufficiency of cerebral circulation; (impaired mental function, memory, confusion, disorientation, reduced motivation, initiative and ability to end ntratsii attention), including with dementia and encephalopathy, - senile pseudomelancholia.
Contraindications
- pregnancy, - lactation period (breastfeeding), - hypersensitivity to the drug.
Use during pregnancy and lactation
The drug is contraindicated for use during pregnancy and lactation (breastfeeding). In experimental studies have not been identified mutagenic and teratogenic effects of the drug, as well as the effect on reproductive function.
Dosage and administration
In acute conditions, the drug is administered intramuscularly or intravenously (slowly) in a daily dose of 1 g (1 ampoule) for 10-15 days, then transferred to the oral administration of the drug in a daily dose of 1.2 g (800 mg / 2 caps. / in the morning and 400 mg / 1 caps / day) for 6 months. In chronic conditions, the drug is administered orally 400 mg (1 caps) 3 times / day. Duration of therapy - 3-6 months. Capsules are recommended to be taken before meals.
Side effects
On the part of the digestive system: nausea (as a result of dopaminergic activation). Other: allergic reactions.
Overdose
Symptoms: dyspepsia. Treatment: gastric lavage, taking activated charcoal, symptomatic therapy.
special instructions
If nausea occurs after taking the drug, the dose should be reduced. Influence on the ability to drive vehicles and control mechanisms Cerepro does not affect the speed of psychomotor reactions.