Doxazosin pills 4 mg 20 pcs
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Active ingredients
Doxazosin
Release form
Pills
Composition
Doxazosin (in the form of mesylate) 4 mg
Pharmacological effect
Selective competitive blocker postsynaptic 1-adrenergic receptors. It causes the expansion of peripheral vessels, which leads to a decrease in round focal disease and a decrease in blood pressure. Improves HDL / total cholesterol, lowering total triglycerides and cholesterol.; With prolonged use, left ventricular hypertrophy regresses, platelet aggregation is suppressed and plasminogen activator is increased in the tissues. The blockade of 1-adrenoreceptors located in the stroma and the capsule of the prostate gland in the bladder neck leads to a decrease in resistance and pressure in the urethra, a decrease in resistance in its internal opening. Improves urodynamics and reduces manifestations of benign prostatic hyperplasia.
Pharmacokinetics
After ingestion is well absorbed from the gastrointestinal tract. Cmax in plasma is achieved in 1.5-3.6 h. Plasma protein binding is 98-99%. Intensively metabolized in the liver. T1 / 2 is 19-22 hours. It is mainly excreted through the intestine as metabolites, 5% - unchanged; 9% excreted by the kidneys.
Indications
Arterial hypertension. Benign prostatic hyperplasia (symptomatic treatment).
Contraindications
Severe liver failure; urinary tract infections; anuria; progressive renal failure; hypotension with orthostatic disorders (including in history); hypotension (refers only to the indication of benign prostatic hyperplasia); concomitant obstruction of the upper urinary tract; chronic urinary tract infections; bladder stones; obstructive disorders of the digestive tract; obstruction of the esophagus; reducing the diameter of the lumen of the digestive tract of any degree; lactose intolerance, lactase deficiency or glucose-galactose malabsorption (due to the presence of lactose in the composition); children and adolescents up to 18 years; lactation period (breastfeeding); hypersensitivity to quinazoline derivatives (for example, to prazosin, terazosin, doxazosin); As a monotherapy: for patients with bladder overflow; anuria with or without progressive renal failure.
Use during pregnancy and lactation
Adequate and strictly controlled studies of the safety of doxazosin during pregnancy and lactation (breastfeeding) have not been conducted. Application is possible only in cases where the potential benefit to the mother outweighs the potential risk to the fetus or child.
Dosage and administration
The initial dose is 1 mg / day. After 1-2 weeks, depending on the clinical situation, the dose may be increased to 2 mg / day, and then after 1-2 weeks to 4 mg, 8 mg or 16 mg / day to achieve the optimal therapeutic effect. The average daily dose is 2-4 mg.; The maximum dose: 16 mg / day.
Side effects
On the part of the cardiovascular system: orthostatic reactions (including fainting), tachycardia, arrhythmia, peripheral edema.; On the part of the digestive system: nausea.; On the part of the central nervous system: dizziness, headache, fatigue, irritability, asthenia, drowsiness.; Other: rhinitis.
Overdose
Symptoms: marked decrease in blood pressure, sometimes accompanied by fainting.; Treatment: put the patient on his back, lifting his legs; symptomatic therapy. Dialysis is ineffective.
Interaction with other drugs
With simultaneous use with antihypertensive drugs, mutual enhancement of effects is possible.; Simultaneous use with PDE-5 inhibitors (sildenafil, tadalafil, tardenafil, vardenafil) in some patients may develop symptomatic arterial hypotension. Do not take doxazosin simultaneously with other blockers .; With simultaneous use with calcium channel blockers, there is some risk of developing severe arterial hypotension. nitrates, agents for general anesthesia, tricyclic antidepressants, ethanol may increase the hypotensive effect. With simultaneous use of drugs that affect the metabolic rate in the liver, doxazosin may be slowed or accelerated. By eliminating the alpha-adrenostimulating effects of epinephrine (adrenaline), doxazosin can lead to tachycardia and arterial hypotension.
special instructions
Caution should be used for pulmonary edema caused by mitral stenosis or aortic stenosis; heart failure with increased cardiac output; right ventricular failure due to embolism of the pulmonary artery or exudative pericarditis; left ventricular failure with low filling pressure; disorders of cerebral circulation; in elderly patients; simultaneous use with PDE-5 inhibitors (the threat of symptomatic arterial hypotension); with liver failure; during pregnancy; during surgery for cataract removal. After taking doxazosin in the initial dose, orthostatic hypotension may develop (first dose phenomenon), especially in the standing position. Most often, this condition is observed in patients with hypovolemia, sodium deficiency, and in the elderly. In this regard, the initial dose is recommended to be taken at bedtime.; There is no clinical experience with doxazosin in children.; Impact on the ability to drive vehicles and control mechanisms the speed of psychomotor reactions, in connection with the possible development of drowsiness, dizziness.