More info
Active ingredients
Kagocel
Release form
Pills
Composition
Active ingredient: Kagocel (Kagocel) Active ingredient concentration (mg): 12
Pharmacological effect
Antiviral drug, inducer of interferon synthesis. The active substance is the sodium salt of the copolymer (1-4) -6-0-carboxymethyl-β-D-glucose, (1-4) -β-D-glucose and (21-24) -2,3,14,15 , 21,24,29,32-octahydroxy-23- (carboxymethoxymethyl) -7,10-dimethyl-4, 13-di (2-propyl) -19,22,26,30,31,3-pentaoxa heptacyclo [23.3.2.216. 20.05.28.08.27.09.18.012.17] dotiaconthus-1,3,5 (28), 6,8 (27), 9 (18), 10, 12 (17), 13,15-decaenea. Causes education in the body human so-called late interferon, which is a mixture of alpha and beta interferon with high antiviral activity. Kagocel causes the production of interferons in virtually all cell populations involved in the antiviral response of the body: T and B lymphocytes, macrophages, granulocytes, fibroblasts, endothelial cells. When ingested a single dose of Kagocel, the titer of interferon in serum reaches its maximum after 48 hours. The interferon response of the body to Kagotsel administration is characterized by prolonged (up to 4-5 days) circulation of interferon in the bloodstream. The dynamics of the accumulation of interferon in the intestine when taking the drug inside does not coincide with the dynamics of the titers of circulating interferon. In the serum, the production of interferon reaches high values only 48 hours after taking Kagocel, while in the intestine the maximum production of interferons is observed already after 4 hours. The preparation Kagocel, when administered in therapeutic doses, is non-toxic and does not accumulate in the body. The drug does not have mutagenic and teratogenic properties, is not carcinogenic and does not have an embryotoxic effect. The most effective treatment with Kagocel is achieved when it is prescribed no later than the 4th day from the onset of acute infection. For prophylactic purposes, the drug can be used at any time, incl. and immediately after contact with the pathogen.
Pharmacokinetics
Absorption and distributionIn case of ingestion, about 20% of the administered dose of the drug enters the general circulation. 24 hours after being introduced into the body, the drug accumulates mainly in the liver, to a lesser extent in the lungs, thymus, spleen, kidneys, lymph nodes.Low concentration is noted in adipose tissue, heart, muscles, testicles, brain, blood plasma. The low content of Kagocel in the brain is explained by the high molecular weight of the drug, which makes it difficult for it to penetrate through the BBB. In the blood plasma, the drug is mainly in bound form: with lipids - 47%, with proteins - 37%. The unbound portion of the drug is about 16%. With daily repeated administration of kagotsel Vd varies widely in all studied organs. The accumulation of the drug in the spleen and lymph nodes is especially pronounced. ExcretionIt is excreted from the body mainly through the intestines: 7 days after ingestion, 88% of the administered dose is excreted from the body, including 90% through the intestines and 10% through the kidneys. In the exhaled air, the drug is not detected.
Indications
Applied in adults and children aged 3 years as a preventive and therapeutic agent for influenza and other acute respiratory viral infections (ARVI), as well as a therapeutic tool for herpes in adults.
Contraindications
Pregnancy and lactation; age up to 3 years; hypersensitivity to the drug components. Lactase deficiency, lactose intolerance, glucose-galactose malabsorption.
Precautionary measures
Do not exceed recommended doses.
Use during pregnancy and lactation
Due to the lack of necessary clinical data, the drug is not recommended for use during pregnancy and lactation (breastfeeding). Effect on the ability to drive motor vehicles and control mechanisms The effect of the drug on the ability to drive vehicles and mechanisms has not been studied.
Dosage and administration
For oral administration.
Side effects
Allergic reactions may develop.
Overdose
Treatment: in case of accidental overdose, it is recommended to prescribe a heavy drink, induce vomiting.
Interaction with other drugs
The drug Kagocel is well combined with other antiviral drugs, immunomodulators and antibiotics (additive effect).
special instructions
To achieve a therapeutic effect, the administration of Kagocel should be started no later than the 4th day from the onset of the disease.