Propicil pills 50 mg 20 pcs
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Active ingredients
Propyl thiouracil
Release form
Pills
Composition
Propyl thiouracil 50 mg; excipients: lactose monohydrate; corn starch; colloidal silicon dioxide; Povidone; gelatinized starch; magnesium stearate
Pharmacological effect
It has a pronounced thyreostatic effect. Interferes with the process of iodization of thyroglobulin, reduces the formation of the active form of iodine in the thyroid gland, blocking the system of peroxidases. Inhibits the conversion of T4 to T3 by forming a reverse T3.
Indications
-thyrotoxicosis (diffuse toxic goiter, toxic thyroid adenoma); -preparation for resection of the thyroid gland; -preparation for treatment with radioactive iodine .; To avoid complications, use only after consulting a doctor.
Contraindications
Hypersensitivity - leukopenia, agranulocytosis; - hypothyroidism; - active hepatitis, liver cirrhosis, abnormal liver function.
Use during pregnancy and lactation
Both thyrotoxicosis and hypothyroidism in pregnant women are associated with an increase in the frequency of miscarriages, stillbirth and developmental abnormalities .; The frequency of developmental abnormalities in cases of treatment with Propitsilom; does not differ from the frequency of spontaneous abnormal development of the fetus .; Dose of Propicil; should be as low as possible to avoid miscarriage, as well as the development of hypothyroidism and goiter in the fetus .; In the last three months of pregnancy, there is often a spontaneous decrease in the severity of thyrotoxicosis .; During pregnancy, treatment is carried out under strict supervision (the level of thyroid hormones should be at the upper limit of the norm, the level of thyrotropin should be below the norm) .; B period of breastfeeding Propicil; It is considered the drug of choice, because its concentration in breast milk is 1/10 of the level in the serum of the mother. However, it is necessary to monitor the newborn, because there are reports of individual cases of hypothyroidism .; With a combination of diffuse toxic goiter and pregnancy Propicil; prescribed only as monotherapy.
Dosage and administration
Inside, without chewing, swallowing whole, with a sufficient amount of liquid, every 6–8 hours; At the beginning of treatment, adults and children over 10 years old are prescribed 75–100 mg (from 1.5 to 2 pills) per day.In severe cases and after a previous load with iodine, the initial daily dose is increased to 300–600 mg (6–12 pills, divided into 4–6 single doses) .; Maintenance dose is 25-150 mg (from 0.5 to 3 pills.) Per day .; At the beginning of treatment, children aged 6 to 10 years receive 50–150 mg (from 1 to 3 pills) per day, and with maintenance treatment, about 25–50 mg (from 0.5 to 1 pills) per day. ; When thyrotoxicosis in newborns is prescribed at 5-10 mg / kg / day (the daily dose is divided into 3 doses). In the absence of a response to treatment, an increase in the dose of 1.5–2 times (75–100%) is recommended .; Maintenance dose is 3-4 mg / kg / day; According to existing data, in patients suffering from renal failure or on hemodialysis, there is no need to adjust the dose. In case of liver diseases, the drug can be taken in recommended doses, taking into account the corresponding contraindications .; The duration of treatment is determined by the individual need of the patient .; Experience of therapeutic use of the drug Propicil; shows that the duration of treatment of thyrotoxicosis in diffuse toxic goiter and toxic adenoma of the thyroid gland should be 1.5-2 years .; When preparing for surgery or treatment with radioactive iodine, the duration of use of the drug should correspond to the individual needs of the patient. Propicil; can be used for the treatment of diffuse toxic goiter in the form of monotherapy, as well as in the "block and replace" scheme.
Side effects
Agranulocytosis is a severe but rare side effect, accompanied by septic complications .; Sometimes rash on the skin, urticaria, stomach pain, arthralgia without signs of inflammation of the joints, the formation of goiter in the newborn; in very rare cases (especially when using the drug in high doses), the following side effects were observed: liver damage (hepatocellular necrosis, transient cholestasis), hypersensitivity reactions, drug fever, lymphadenopathy and thrombocytopenia .; There are reports of individual cases of neuromuscular disorders, polyarthritis, lupus-like syndrome, periarteritis nodosa, gastrointestinal disorders (nausea, vomiting), dizziness, disorders of erythropoiesis, hemolysis, Coombs positive reaction, interstitial pneumonia, peripheral edema and alopecia. During treatment with Propitsilom; an enlargement of the thyroid gland may occur.
Overdose
Cases of acute intoxication were not observed. Chronic overdose leads to the development of goiter and hypothyroidism with symptoms that are dependent on the severity of hypothyroidism, due to the specific action of the antithyroid drug .; Treatment: no special measures / measures. Gastric lavage and endoscopic removal of residual pills are not effective due to the rapid absorption of the active substance. With the development of goiter and hypothyroidism, accompanied by symptoms correlated with the severity of hypothyroidism and caused by chronic overdose of the drug, treatment with Propicil, stop and wait for a spontaneous recovery of thyroid function. Thyroxine replacement therapy is performed if this is justified by the severity of hypothyroidism.
Interaction with other drugs
In case of treatment with Propitsilom; carried out according to the “block and replace” scheme in combination with thyroxin, Propicil dose; should be increased .; Thyrostatic effect of Propicil; decreases with simultaneous or previous use of iodine-containing drugs or radiopaque substances .; In connection with the ability of propylthiouracil to affect the effect of the free active fractions of propranolol and coumarin derivatives, an additional correction of the doses of these drugs is necessary.
special instructions
Propitsil; contraindicated in patients who have previously experienced severe side effects of the drug (agranulocytosis, severe liver damage) .; In the event of a pathological change in the number of blood corpuscles and an increase in transaminase activity, Propicil; can only be used under the strict supervision of a doctor .; Influence on ability to driving of the car and to control of cars and mechanisms. Does not affect.