Buy Ketorolac solution in in mm 30mg ml 1ml amp N10

Ketorolac solution in in mm 30mg ml 1ml amp N10

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11,95 $

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Active ingredients

Ketorolac

Composition

1 ml of ketorolac trometamol 30 mg. Excipients: lactose monohydrate, corn starch, pregelatinized starch, microcrystalline cellulose, povidone, magnesium stearate, carboxymethyl starch sodium.

Pharmacological effect

NSAIDs. Ketorolaka trometamol has a pronounced analgesic effect, also has anti-inflammatory and moderate antipyretic effect. The mechanism of action is associated with the non-selective inhibition of the activity of COX-1 and COX-2, catalyzing the formation of prostaglandins from arachidonic acid, which play an important role in the pathogenesis of pain, inflammation and fever. The strength of the analgesic effect is comparable with morphine, far superior to other NSAIDs. The beginning of the analgesic effect is observed, respectively, in 0.5 h, the maximum effect is achieved in 1-2 h.

Indications

Pain syndrome of strong and moderate severity: - injuries. - toothache . - pain in the postoperative period. - oncological diseases . - myalgia, arthralgia. - neuralgia, sciatica. - sprains, stretching. - rheumatic diseases. Designed for symptomatic therapy, reducing pain and inflammation at the time of application, does not affect the progression of the disease.

Contraindications

- complete or incomplete combination of bronchial asthma, recurrent nasal polyposis and paranasal sinuses and intolerance to acetylsalicylic acid or other NSAIDs (including in history) - urticaria, rhinitis caused by NSAIDs (in history) - intolerance to drugs of pyrazolone diaphragms - hypersensitivity to pyrazolone inhalants - hypoglycemic drugs (in history) - intolerance to drugs of the pyrazolone group - hypoglyphiasis (in the anamnesis) - hypersensitivity to pyrazolone diaphragms - hypersensitivity to pyrazolone diaphragms - hypersensitivity to pyrazolone diaphragms - hypersensitivity to pyrazolone diaphragms - hypersensitivity to pyrazolone diaphragms - hypersensitivity to pyrazolone diaphragms - hypersensitivity to pyrazolone diaphragms - hypersensitivity to pyrazolone diaphragms - hypersensitivity to pyrazolone; (regardless of the cause that caused it) - erosive and ulcerative lesions of the gastrointestinal tract in the acute phase - hypocoagulation (including hemophilia) - bleeding or high risk of their development - severe renal failure (CC less than 30 ml / min) - severe liver failure or active liver disease - condition after coronary artery bypass surgery - confirmed hyperkalemia - inflammatory bowel disease - childbirth period - lactation period - children's age up to 16 years (safety and efficacy have not been established) - hypersensitivity to the components of the drug.With caution: bronchial asthma, factors that increase toxic effects on the gastrointestinal tract (alcoholism, smoking and cholecystitis) postoperative period, chronic heart failure, edematous syndrome, arterial hypertension, impaired renal function (serum creatinine less than 50 mg / l), cholestasis, sepsis, system lupus erythematosus, concurrent use with other NSAIDs, ischemic heart disease, cerebrovascular diseases, dyslipidemia / hyperlipidemia, diabetes mellitus, peripheral artery disease, chronic renal failure (CC 30-60 ml / min), ulcerative lesions of the gastrointestinal tract in history, the presence of Helicobacter pylori infection, long-term use of NSAIDs, severe somatic diseases, simultaneous administration of oral GCS (including prednisolone), anticoagulants (including warfarin ), antiplatelet agents (including clopidogrel), selective serotonin reuptake inhibitors (including citalopram, fluoxetine, paroxetine, sertraline), elderly patients (over 65).

Use during pregnancy and lactation

Use in pregnancy and lactation is contraindicated. At the time of treatment should stop breastfeeding.

Side effects

Frequency of side effects: often (more than 3%), less often (1-3%), rarely (less than 1%). On the part of the digestive system: often - gastralgia, diarrhea. less often - stomatitis, flatulence, constipation, vomiting, feeling of fullness in the stomach. rarely - loss of appetite, nausea, erosive and ulcerative lesions of the gastrointestinal tract (including with perforation and / or bleeding - abdominal pain, spasm or burning in the epigastric region, blood in the feces or melena, vomiting with blood or like "coffee thick ", nausea, heartburn), cholestatic jaundice, hepatitis, hepatomegaly, acute pancreatitis. From the urinary system: rarely - acute renal failure, back pain, hematuria, azotemia, hemolytic-uremic syndrome (hemolytic anemia, renal failure, thrombocytopenia, purpura), increased urination, increased or decreased urine volume, nephritis, edema of the renal origin. From the senses: rarely - hearing loss, tinnitus, blurred vision (including blurred visual perception). On the part of the respiratory system: rarely - bronchospasm or shortness of breath, rhinitis, pulmonary edema, laryngeal edema (difficulty breathing).On the part of the nervous system: often - headache, dizziness, drowsiness. rarely - aseptic meningitis (fever, severe headache, cramps, stiff neck and / or back muscles), hyperactivity (mood changes, anxiety), hallucinations, depression, psychosis, fainting. Since the cardiovascular system: less often - increased blood pressure. On the part of the blood-forming organs: rarely - anemia, eosinophilia, leukopenia. On the part of the blood coagulation system: rarely - bleeding from a postoperative wound, epistaxis, rectal bleeding. On the part of the skin: less often - skin rash (including maculo-papular rash), purpura. rarely, exfoliative dermatitis (fever with or without chills, hyperemia, hardening or peeling of the skin, an increase and / or pain in the tonsils), urticaria, malignant exudative erythema (Stevens-Johnson syndrome), toxic epidermal necrolysis (Lyell's syndrome). Allergic reactions: rarely - anaphylaxis or anaphylactoid reactions (discoloration of the skin, skin rash, urticaria, itchy skin, tachypnea, eyelid edema, periorbital edema, heaviness in the chest, wheezing). Local reactions: less often - burning or pain at the injection site. Other: often - swelling (face, legs, ankles, fingers, feet, weight gain). less often - increased sweating, rarely - swelling of the tongue, fever.

special instructions

Frequency of side effects: often (more than 3%), less often (1-3%), rarely (less than 1%). On the part of the digestive system: often - gastralgia, diarrhea. less often - stomatitis, flatulence, constipation, vomiting, feeling of fullness in the stomach. rarely - loss of appetite, nausea, erosive and ulcerative lesions of the gastrointestinal tract (including with perforation and / or bleeding - abdominal pain, spasm or burning in the epigastric region, blood in the feces or melena, vomiting with blood or like "coffee thick ", nausea, heartburn), cholestatic jaundice, hepatitis, hepatomegaly, acute pancreatitis. From the urinary system: rarely - acute renal failure, back pain, hematuria, azotemia, hemolytic-uremic syndrome (hemolytic anemia, renal failure, thrombocytopenia, purpura), increased urination, increased or decreased urine volume, nephritis, edema of the renal origin.From the senses: rarely - hearing loss, tinnitus, blurred vision (including blurred visual perception). On the part of the respiratory system: rarely - bronchospasm or shortness of breath, rhinitis, pulmonary edema, laryngeal edema (difficulty breathing). On the part of the nervous system: often - headache, dizziness, drowsiness. rarely - aseptic meningitis (fever, severe headache, cramps, stiff neck and / or back muscles), hyperactivity (mood changes, anxiety), hallucinations, depression, psychosis, fainting. Since the cardiovascular system: less often - increased blood pressure. On the part of the blood-forming organs: rarely - anemia, eosinophilia, leukopenia. On the part of the blood coagulation system: rarely - bleeding from a postoperative wound, epistaxis, rectal bleeding. On the part of the skin: less often - skin rash (including maculo-papular rash), purpura. rarely, exfoliative dermatitis (fever with or without chills, hyperemia, hardening or peeling of the skin, an increase and / or pain in the tonsils), urticaria, malignant exudative erythema (Stevens-Johnson syndrome), toxic epidermal necrolysis (Lyell's syndrome). Allergic reactions: rarely - anaphylaxis or anaphylactoid reactions (discoloration of the skin, skin rash, urticaria, itchy skin, tachypnea, eyelid edema, periorbital edema, heaviness in the chest, wheezing). Local reactions: less often - burning or pain at the injection site. Other: often - swelling (face, legs, ankles, fingers, feet, weight gain). less often - increased sweating, rarely - swelling of the tongue, fever.

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