Mexidol injection 50mg ml ampoule 2ml N50
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Description
Mexidol is an innovative, original domestic drug with a powerful anti-ischemic effect. The drug has a wide range of pharmacological effects, which can be realized at least at two levels - neuronal and vascular. It has powerful anti-ischemic, neuroprotective, antihypoxic, nootropic, vegetotropic, anti-stress, anxiolytic, anticonvulsant and other actions. Mexidol is used in the treatment of urgent conditions, such as acute ischemic stroke, traumatic brain injury, acute purulent-inflammatory processes of the abdominal cavity (acute pancreatitis, peritonitis).
Active ingredients
Ethyl methyl hydroxypyridine succinate
Pharmacological effect
Mexidol has antihypoxic, membrane-protective, nootropic, anticonvulsant, anxiolytic effect, increases the body's resistance to stress. The drug increases the body's resistance to the effects of major damaging factors, to oxygen-dependent pathological conditions (shock, hypoxia and ischemia, impaired cerebral circulation, intoxication with alcohol and antipsychotic drugs (neuroleptics)). Mexidol improves cerebral metabolism and blood circulation of the brain, improves microcirculation and rheology of the blood , reduces platelet aggregation. Stabilizes membrane structures of blood cells (erythrocytes and platelets) during hemolysis. It has a hypolipidemic effect, reduces the level of total cholesterol and LDL. Reduces enzymatic toxemia and endogenous intoxication in acute pancreatitis. The mechanism of action of Mexidol is due to its antihypoxant, antioxidant and membrane-protective action. It inhibits the processes of lipid peroxidation, increases the activity of superoxide dismutase, increases the ratio of lipid-protein, reduces the viscosity of the membrane, increases its fluidity. Modulates the activity of membrane-bound enzymes (calcium-independent phosphodiesterase, adenylate cyclase, acetylcholinesterase), receptor complexes (benzodiazepine, GABA, acetylcholine), which enhances their ability to bind to ligands, helps preserve the structural and functional organization of the biomembrane, and the biomembrane connection and the center of the phone without using the method and the biomembrane that the center of the biomembrane and the center of the biomembrane, and the biomembrane, and the center of a biomembrane, and the biomembrane, and the center of a biomembrane, and the biomembrane, and the center of a biomembrane, and the biomembrane, and the center of a biomembrane, and the biomembrane, and the center of a biomembrane.Mexidol® increases the dopamine content in the brain. It causes an increase in the compensatory activity of aerobic glycolysis and a decrease in the degree of inhibition of oxidative processes in the Krebs cycle under hypoxic conditions, with an increase in ATP, creatine phosphate and activation of energy-synthesizing functions of mitochondria, and stabilization of cell membranes. electrical activity and myocardial contractility, as well as increases coronary blood flow in the ischemic zone, reduces the consequences reperfusion syndrome in acute coronary insufficiency. Increases the antianginal activity of nitro drugs. Mexidol helps to preserve retinal ganglion cells and optic nerve fibers with progressive neuropathy, caused by chronic ischemia and hypoxia. It improves the functional activity of the retina and optic nerve, increasing visual acuity.
Pharmacokinetics
When i / m administration is determined in the blood plasma for 4 hours after administration. The time to reach the maximum concentration of Tmax - 0.45–0.5 h. Cmax with a dose of 400–500 mg is 3.5–4.0 μg / ml. Mexidol quickly moves from the bloodstream to organs and tissues and quickly eliminates from the body. The drug retention time (MRT) is 0.7–1.3 hours. The drug is excreted mainly in the urine, mainly in the glucuronic conjugate form and in small quantities in unchanged form.
Indications
- acute disorders of cerebral circulation, - traumatic brain injury, consequences of traumatic brain injuries, - dyscirculatory encephalopathy, - vegetative dystonia syndrome, - mild cognitive disorders of atherosclerotic genesis, - anxiety disorders in neurotic and neuro-like conditions, - acute infarct, infarct. days) as part of complex therapy, - primary open-angle glaucoma of different stages, as part of complex therapy, - relief of withdrawal syndrome in alcoholism with a prevalence of mnevrozopodobnyh and vegetative-vascular disorders, - acute intoxication with antipsychotics, - acute purulent-inflammatory processes of the abdominal cavity (acute necrotic pancreatitis, peritonitis) as part of complex therapy.
Contraindications
Acute disorders of the liver and kidneys, increased individual sensitivity to the drug. Strictly controlled clinical studies of the safety of the drug Mexidol in children, during pregnancy and breastfeeding were not conducted.
Use during pregnancy and lactation
Strictly controlled clinical studies of the safety of the drug Mexidol in children, during pregnancy and breastfeeding were not conducted.
Dosage and administration
V / m or / in (jet or drip). With the infusion method of administration, the drug should be diluted in a 0.9% solution of sodium chloride. Mexidol is injected slowly for 5–7 minutes in a jet, and 40–60 drops per minute in a drip. The maximum daily dose should not exceed 1200 mg. In acute disorders of cerebral circulation, Mexidol is used in the first 10–14 days - intravenously in a drop of 200–500 mg 2–4 times a day, then in a dose of 200–250 mg 2– 3 times a day for 2 weeks. When traumatic brain injury and the effects of traumatic brain injury, Mexidol is used for 10-15 days intravenously in a drop of 200-500 mg 2-4 times a day. During dyscirculatory encephalopathy in the decompensation phase Mexidol should be administered intravenously in a jet or drip at a dose of 200–500 mg 1–2 times a day for 14 days. Then, the intramuscular dose of 100–250 mg / day for the next 2 weeks. For course prophylaxis of dyscirculatory encephalopathy, the drug is administered intramuscularly at a dose of 200–250 mg twice a day for 10–14 days. For mild cognitive impairment in patients elderly and with anxiety disorders, the drug is administered intramuscularly at a daily dose of 100–300 mg / day for 14–30 days. In acute myocardial infarction as part of complex therapy, Mexidol is administered intravenously or intramuscularly for 14 days, against the background of traditional therapy of heart attack myocardium, including nitra you, beta-blockers, inhibitors of angiotensin-converting enzyme (ACE), thrombolytics, anticoagulant and antiaggregant agents, and symptomatic remedies as indicated. In the first 5 days, for maximum effect, the drug is preferably administered intravenously, in the next 9 days Mexidol can be administered intramuscularly. Intravenous administration of the drug is made by drip infusion, slowly (to avoid side effects) with a 0.9% solution of sodium chloride or 5% solution of dextrose (glucose) in a volume of 100–150 ml during s 30-90 min. If necessary, slow jet administration of the drug is possible, with a duration of at least 5 minutes. The administration of the drug (intravenous or intramuscular) is carried out 3 times a day, every 8 hours.The daily therapeutic dose is 6–9 mg / kg body weight per day, a single dose - 2–3 mg / kg body weight. The maximum daily dose should not exceed 800 mg, a single 250 mg. At open-stage glaucoma of various stages, Mexidol is administered intramuscularly at 100–300 mg / day intramuscularly, 1–3 times per day for 14 days. at a dose of 200–500 mg intravenously in a drip or intramuscularly 2–3 times a day for 5–7 days. In acute intoxication with antipsychotics, the drug is administered intravenously at a dose of 200–500 mg / day for 7–14 days. In acute purulent-inflammatory processes of the abdominal cavity (acute necrotic sky pancreatitis, peritonitis) drug administered in the first day in the preoperative and postoperative. The doses administered depend on the form and severity of the disease, the extent of the process, the clinical course variants. Cancellation of the drug should be made gradually only after a stable positive clinical and laboratory effect. In acute edematous (interstitial) pancreatitis, Mexidol is prescribed 200–500 mg 3 times a day, in / in drip (in 0.9% sodium chloride solution) and / m Mild severity of necrotic pancreatitis - 100–200 mg 3 times a day in / in drip (in 0.9% sodium chloride solution) and in / m. The average severity - 200 mg 3 times a day, in / in the drip (in 0.9% sodium chloride solution). Severe - in the pulse dosage of 800 mg on the first day, with a double mode of administration, then 200-500 mg 2 times a day with a gradual decrease in the daily dose. Extremely severe course is in the initial dosage of 800 mg / day until persistent relief of pancreatic shock, stabilization of 300–500 mg 2 times a day in / in the drip (in 0.9% sodium chloride solution) with a gradual decrease in the daily dosage.
Side effects
Perhaps the appearance of nausea and dryness of the oral mucosa, drowsiness, allergic reactions.
Overdose
Overdose may cause drowsiness.
Interaction with other drugs
Enhances the action of benzodiazepine anxiolytics, anticonvulsants (carbamazepine), anti-Parkinsonian drugs (levodopa). Reduces the toxic effects of ethyl alcohol.
special instructions
In some cases, especially in predisposed patients with bronchial asthma, with increased sensitivity to sulfites, severe hypersensitivity reactions may develop.