Broxinac eye drops 0.09% 1.7ml
Condition: New product
1000 Items
Rating:
Be the first to write a review!
More info
Active ingredients
Bromfenac
Release form
Drops
Composition
Per 1 ml: sodium bromfenac sesquihydrate 0.9 mg, which corresponds to the content of bromfenac 1.035 mg Auxiliary substances: benzalkonium chloride - 0.05 mg, boric acid - 11 mg, disodium edetate dihydrate - 0.2 mg, polysorbate 80 - 1.5 mg, povidone K-30 - 20 mg , sodium borate decahydrate - 11 mg, sodium anhydrous sulfite - 2 mg, sodium hydroxide - to pH 8.3, water d / and - to 1 ml.
Pharmacological effect
Bromfenac is a nonsteroidal anti-inflammatory drug (NSAID), which has anti-inflammatory and analgesic effects, blocks the synthesis of prostaglandins from arachidonic acid, by inhibiting cyclooxygenase 1 and 2, which reduces inflammation and reduces the pain response. eye inflammation. In animal studies, prostaglandins contributed to the violation of the hematophthalmic barrier, increased vascular permeability, caused vasodilation, leukocytosis, increased intraocular pressure.
Pharmacokinetics
The concentration of the drug in the blood plasma is well below the limit of measurement and has no clinical significance. Bromfenac effectively penetrates the cornea: with a single installation, the concentration in the aqueous humor of the eye is 79 ± 68 ng / ml 150-180 minutes after applying the drug. This concentration is maintained for 12 hours in the aqueous humor of the eye, with a therapeutically significant concentration in the tissues of the eye, including the retina, up to 24 hours. The half-life of aqueous humor is about 1.4 hours.
Indications
Treatment of postoperative inflammation and pain reduction in patients after cataract extraction.
Contraindications
Hypersensitivity to the components of the drug, as well as to other nonsteroidal anti-inflammatory drugs; Use of the drug is contraindicated in patients who have attacks of bronchial asthma, urticaria and symptoms of acute rhinitis, are amplified when taking acetylsalicylic acid and other NSAIDs; Age 18 years (safety and efficacy drug in children have not been studied).
Precautionary measures
Sodium sulfite contained in the preparation can cause an allergic reaction, including anaphylactic shock, asthma attacks in susceptible people.Sensitivity to sulfites is increased in individuals with bronchial asthma and allergic reactions in the history. When using Broxinac, there is a possibility of developing cross-sensitivity to acetylsalicylic acid, derivatives of phenylacetyl acid, and other NSAIDs. Care must be taken when treating individuals who have previously detected sensitivity to these drugs. NSAIDs can increase bleeding time as a result of a violation of platelet aggregation. The use of local NSAIDs in combination with ophthalmologic operations can increase bleeding of eye tissues (including in the anterior chamber of the eye). Broxinac should be used with caution in patients whose history has a tendency to bleeding, or if patients receive other medications that can increase blood clotting time. corneal epithelium, diabetes mellitus, superficial eye diseases (for example, dry eye syndrome), rheumatoid arthritis, or repeated surgical procedures Interventions carried out over a short period of time may have an increased risk of corneal adverse reactions.
Use during pregnancy and lactation
Pregnancy The safety of using bromfenac 0.09% eye drops during pregnancy has not been studied. However, data from several studies of animal embryotoxicity suggest the possibility of reducing the viability of the embryo. The use of the drug is possible if the expected effect for the mother outweighs the potential risk to the fetus. It is necessary to avoid the appointment of the drug in late pregnancy. Breastfeeding period. Care should be taken when applying to women during breastfeeding.
Dosage and administration
Installations in the conjunctival sacIn one drop once a day. Treatment begins 1 day before the surgery and continues during the first 14 days of the postoperative period (including the day of surgery). Instructions in case of missing one or more doses of the drugIf the pass in the use of the drug is approaching 24 hours, the drug should be applied at the next scheduled time, not doubling the dose to compensate for the missed dose. Use in patients over 65 years of age. The mode of taking the drug does not differ from that in younger patients.
Side effects
WHO side effects rate classification: very often (more than 1/10); often (from greater than 1/100 to less than 1/10); sometimes (from greater than 1/1000 to less than 1/100); rarely (from greater than 1/10 000 to less than 1/1000); very rarely (from less than 1 / 10,000, including individual messages). When a single use of the drug, the following side effects were observed: Disturbances of the organs of vision: Often (observed in 2-7% of patients): discomfort and unusual sensations in the eyes, eye irritation, pain, itching and burning in the eyes, redness of the eyes, conjunctival hyperemia, inflammation of the iris of the eye. Very rare: there are isolated post-marketing reports of corneal erosion, corneal perforation, corneal thinning, destruction of the epithelium. Violations of the nervous system Topics: headache. In the double application of a 0.09% solution of bromfenac, the following reactions were also observed: Violations on the part of the organs of vision: Sometimes: reduced visual acuity, retinal hemorrhage, corneal edema, photophobia, bleeding from the eyelid vessels, exudates on the fundus of the eyelid. : corneal ulcer, Disturbances of the respiratory system, chest and mediastinal organs: nosebleeds, cough, nasal discharge, asthma. General disorders and disorders at the injection site: swelling of the face.
Overdose
If you accidentally use the drug inside, you must immediately drink a large amount of liquid to reduce the concentration of the drug in the stomach.
Interaction with other drugs
The drug can be used simultaneously with other ophthalmologic drugs:? -Adrenomimetikami,? -Adrenoblockers, carbonic anhydrase inhibitors, mydriatics. In this case, the drugs should be applied with a break of at least five minutes.
special instructions
The use of local NSAIDs for 24 hours before surgery on the eyes and within 14 days after ophthalmologic surgery may increase the risk of occurrence and severity of adverse reactions from the cornea. The use of local NSAIDs can lead to the development of keratitis.In some susceptible patients, long-term use of local NSAIDs can cause epithelial rupture, corneal thinning, corneal erosion, ulceration of the cornea, or corneal perforation. These side effects may create a risk of vision loss. Patients with signs of corneal epithelium rupture should immediately discontinue use of the drug and be under medical supervision until the cornea is normal. Using NSAIDs can slow the healing process, especially when used together with local corticosteroids. Patients should be warned that delayed healing may occur during the use of NSAIDs. When using Broxinac, patients should not use contact lenses. Patients should be warned not to touch the dropper tip and not to touch any surface, this can lead to contamination the contents of the bottle. The effect on the ability to drive vehicles and control mechanisms The drug has little effect on the ability to drive vehicles and control mechanisms. Perhaps a short-term blurred vision after the injection, it is therefore recommended to wait until the full recovery of vision before proceeding to drive vehicles and control mechanisms.