Ciprolet pills 250 mg 10 pcs
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Active ingredients
Ciprofloxacin
Release form
Pills
Composition
1 tablet contains: Ciprofloxacin hydrochloride 291.106 mg, which corresponds to the content of ciprofloxacin 250 mg. Additional substances: corn starch - 50.323 mg, microcrystalline cellulose - 7.486 mg, croscarmellose sodium - 10 mg, colloidal silicon dioxide - 5 mg, 5mg of calcium powder, 5 mg, croscarmellose sodium, 5mg of talc, 5 mg of calcium chloride, 5 mg of charcoallose sodium, 5 mg of talc; - 3.514 mg.
Pharmacological effect
A broad-spectrum antibacterial drug from the group of fluoroquinolones. Bactericidal effect. The drug inhibits the enzyme DNA gyrase of bacteria, as a result of which DNA replication and synthesis of cellular proteins of bacteria are violated. Ciprofloxacin acts both on reproducing microorganisms and on those in the resting phase. Gram-negative aerobic bacteria are sensitive to ciprofloxacin: Escherichia coli, Salmonella spp., Shigella spp., Citrobacter spp., Klebsiella spp., Enterobacter spp. Spp., Citrobacter spp., Klebsiella spp., Enterobacter spp. , Serratia marcescens, Hafhia alvei, Edwardsiella tarda, Providencia spp., Morganella morganii, Vibrio spp., Yersinia spp .; other gram-negative bacteria: Haemophilus spp., Pseudomonas aeruginosa, Moraxella catarrhalis, Aeromonas spp., Pasteurella multocida, Plesiomonas shigelloides, Campylobacter jejuni, Neisseria spp .; Some intracellular pathogens include: Legionella pneumila, Brucella spp., Chlamydia trachomatis, Listeria monocytogenes, Mycobacterium tuberculosis, Mycobacterium kansasii, Mycobacterium avium-intracellulare. (S.aureus, S.haemolyticus, S.hominis, S.saprophyticus), Streptococcus spp. (St. pyogenes, St.agalactiae). Most of the staphylocists The effect of the drug on Treponema pallidum is not well understood.
Pharmacokinetics
When administered orally, ciprofloxacin is rapidly absorbed from the gastrointestinal tract. Bioavailability of the drug is 50-85%. Cmax of the drug in the blood serum of healthy volunteers after oral administration of the drug (before meals) at a dose of 250, 500, 750 and 1000 mg is achieved in 1-1.5 hours and is 1.2, 2.4, 4.3 and 5.4 mcg / ml, respectively. Orally taken ciprofloxacin is distributed in tissues and body fluids. High concentrations of the drug are observed in bile, lungs, kidneys, liver, gallbladder, uterus, seminal fluid, prostate tissue, tonsils, endometrium, fallopian tubes and ovaries. The concentration of the drug in these tissues is higher than in serum. Ciprofloxacin also penetrates well into the bones, eye fluid, bronchial secretions, saliva, skin, muscles, pleura, peritoneum, lymph. The accumulated concentration of ciprofloxacin in blood neutrophils is 2-7 times higher than in serum. The Vd in the body is 2-3.5 liters / kgThe drug penetrates into the cerebrospinal fluid in a small amount, where its concentration is 6-10% of that of serum. The degree of ciprofloxacin binding to plasma proteins is 30%. In patients with unchanged kidney function, T1 / 2 is usually 3-5 hours. ciprofloxacin is excreted through the kidneys. With the urine output 50-70%. From 15 to 30% is excreted with feces. In case of impaired renal function, T1 / 2 increases. Patients with severe renal insufficiency (CC below 20 ml / min / 1.73m2) should be given half the daily dose of the drug.
Indications
Infectious and inflammatory diseases caused by microorganisms susceptible to ciprofloxacin, including: - respiratory tract infections; upper respiratory tract infections; kidney and urinary tract infections; genital infections; gastrointestinal infections (including mouth) , teeth, jaws); - infections of the gallbladder and biliary tract; - infections of the skin, mucous membranes and soft tissues; - infections of the musculoskeletal system; - sepsis; - peritonitis. Prevention and treatment of infections in patients with reduced immunity (during therapy immunosuppressants).
Contraindications
- pseudomembranous colitis; - pregnancy; - lactation period (breastfeeding); - children and adolescents under 18 years of age; - hypersensitivity to ciprofloxacin or other drugs from the fluoroquinolone group.
Precautionary measures
Precautions should be prescribed the drug in patients with severe atherosclerosis of the cerebral vessels, impaired cerebral circulation, mental illness, convulsive syndrome, epilepsy, severe renal and / or hepatic insufficiency, as well as elderly patients.
Use during pregnancy and lactation
The drug is contraindicated for use during pregnancy and lactation.
Dosage and administration
The dose of Ciprolet depends on the severity of the disease, type of infection, body condition, age, body weight and kidney function. In uncomplicated diseases of the kidneys and urinary tract, 250 mg 2 times / day are prescribed, and in severe cases 500 mg 2 times / day. For diseases of the lower respiratory tract of moderate severity - 250 mg 2 times / day, and in more severe cases - 500 mg 2 times / day. For the treatment of gonorrhea, a single dose of the drug Ciprolet is recommended at a dose of 250-500 mg. For gynecological diseases, severe enteritis and colitis Coy temperature, prostatitis,osteomyelitis prescribed 500 mg 2 times / day (for the treatment of conventional diarrhea can be used in a dose of 250 mg 2 times / day). Tablets should be taken on an empty stomach, drinking plenty of fluids. Duration of treatment depends on the severity of the disease, but treatment should always continue at least 2 days after the disappearance of the symptoms of the disease. Usually the duration of treatment is 7-10 days. Patients with severely impaired renal function should be given half the dose of the drug.
Side effects
On the part of the digestive system: nausea, diarrhea, vomiting, abdominal pain, flatulence, anorexia, cholestatic jaundice (especially in patients with past liver diseases), hepatitis, hepatonecrosis, increased activity of hepatic transaminases and alkaline membrane effects. From the nervous system: dizziness, headache , fatigue, anxiety, tremor, insomnia, nightmares, peripheral paralgesia (anomaly of perception of pain), sweating, increased intracranial pressure, anxiety, confusion I, depression, hallucinations, as well as other manifestations of psychotic reactions (rarely progressing to conditions in which the patient can harm himself), migraine, fainting, cerebral arteries thrombosis. On the part of the sense organs: taste and smell disorders, visual impairment (diplopia, change in color perception), tinnitus, hearing loss. From the cardiovascular system: tachycardia, cardiac arrhythmias, lowering blood pressure, flushing to the skin of the face. From the hematopoietic system: leukopenia, granulocytopenia, anemia, thrombocyte heating, leukocytosis, thrombocytosis, hemolytic anemia. On the laboratory side: hypoprothrombinaemia, hypercreatininemia, hyperbilirubinemia, hyperglycemia. On the urinary system: hematuria, crystalluria (especially with alkaline urine and low diuresis, and in the gymnasium; albuminuria, urethral hemorrhages, hematuria, reduced nitrogen-secreting kidney function, interstitial nephritis. Allergic reactions: pruritus, urticaria, blistering, accompanied by blood lesions, and small nodules that form scabs, drug fever, point hemorrhages (petechiae),swelling of the face or larynx, dyspnea, eosinophilia, increased photosensitivity, vasculitis, nodular erythema, exudative erythema multiforme, Stevens-Johnson syndrome (malignant exudative erythema), toxic epidermal necrolysis (Lyell’s syndrome). tendovaginitis, tendon ruptures, myalgia. Others: general weakness, superinfection (candidiasis, pseudomembranous colitis).
Overdose
Treatment: it is necessary to carefully monitor the patient's condition, to do a gastric lavage, to carry out usual emergency measures, to ensure an adequate flow of fluid. With the help of hemo- or peritoneal dialysis, only an insignificant (less than 10%) amount of the drug can be derived. The specific antidote is unknown.
Interaction with other drugs
With simultaneous use with didanosine Ciprolet ciprofloxacin absorption decreases due to formation of complexes with ciprofloxacin didanosine contained in aluminum and magnesium solyami.Odnovremenny reception Ciprolet theophylline and may lead to increased concentrations of theophylline in the plasma, due to competitive inhibition of the binding sites of cytochrome P450, leading to an increase in theophylline T1 / 2 and an increased risk of toxic action associated with theophylline. Simultaneous administration of antacids, also preparations containing ions of aluminum, zinc, iron or magnesium, can cause a decrease in ciprofloxacin absorption, therefore the interval between administration of these drugs should be at least 4 hours. With simultaneous use of Ciprolet and anticoagulants, the bleeding time is prolonged. With simultaneous use of Ciprolet and cyclosporine, nephrotoxic increases the action of the latter.
special instructions
Patients with epilepsy, bouts of convulsions in history, vascular diseases and organic brain damage due to the threat of adverse reactions from the CNS Ciprolet should be prescribed only for health reasons. If you develop severe or prolonged diarrhea during or after Tsiprolet's treatment, pseudomembranous colitis should be excluded , which requires the immediate cancellation of the drug and the appointment of appropriate treatment. In the event of pain in the tendons or the first signs of tendovagini and treatment should be discontinued due to the fact,that individual cases of inflammation and even rupture of the tendons are described during treatment with fluoroquinolones. During treatment with Ciprolet, it is necessary to ensure sufficient amount of fluid while observing normal diuresis. Ciprolet host should be careful when driving a car and doing other potentially dangerous activities that require yshennogo attention and psychomotor speed reactions (especially with simultaneous use of alcohol).