Dexalgin granules for the preparation of suspensions 25mg package 2.5g N10
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Active ingredients
Composition
Granules for the preparation of oral solution irregular shape, yellow with a lemon smell.
| 1 pack | |
| dexketoprofena trometamol | 36.9 mg, |
| what corresponds to the content of dexketoprofen | 25 mg |
Excipients: ammonium glycyrrhizinate - 2 mg, neohesperidin dihydrochalcon - 1.5 mg, quinoline yellow dye (E104) - 1.2 mg, lemon flavoring - 40 mg, sucrose with colloidal silicon dioxide (500: 1) - 2418 mg.
Pharmacological effect
NSAIDs. It has anti-inflammatory, analgesic and antipyretic effects. The mechanism of action is based on the inhibition of the synthesis of prostaglandins due to the suppression of COX.
Analgesic effect occurs 30 minutes after administration, the duration of action - 4-6 hours.
Pharmacokinetics
After taking the drug inside Cmax dexketoprofen in humans is achieved on average after 30 minutes (15-60 minutes). Plasma protein binding - 99%. The average Vd is less than 0.25 l / kg. T1 / 2 is 1.65 hours. It is metabolized. Excreted mainly by the kidneys as metabolites.
Indications
Mild and moderate intensity pain syndrome in the following diseases and conditions: acute and chronic inflammatory diseases of the musculoskeletal system (rheumatoid arthritis, spondylitis, arthrosis, osteochondrosis); dysmenorrhea; toothache.
Contraindications
Peptic ulcer and duodenal ulcer, gastrointestinal bleeding, active bleeding of various origins, increased bleeding, anticoagulant therapy, Crohn's disease, ulcerative colitis, asthma (including history), severe heart failure, renal failure, hepatic insufficiency, pregnancy, lactation, hypersensitivity to dexketoprofen or other NSAIDs.
Contraindicated in renal failure. For patients with impaired renal function, the initial dose is not more than 50 mg / day.
Contraindicated in liver failure. For patients with impaired liver function, the initial dose is not more than 50 mg / day.
Precautionary measures
Caution should be exercised in the appointment of the drug to elderly patients. For the elderly, the initial dose is not more than 50 mg / day.
Use during pregnancy and lactation
Use during pregnancy and lactation is contraindicated.
Dosage and administration
Is ingested. The average recommended single dose is 12.5 mg - 1-6 times / day every 4-6 hours as needed, or 25 mg 1-3 times / day every 8 hours.
The maximum daily dose is 75 mg. Duration of use - no more than 3-5 days.
For patients with impaired liver or kidney function, the elderly, the initial dose is not more than 50 mg / day.
Side effects
On the part of the digestive system: heartburn, abdominal pain; rarely - erosive and ulcerative lesions of the digestive tract.
On the part of the nervous system: headaches, dizziness, nervousness, sleep disturbance, paresthesia.
Since the cardiovascular system: heartbeat, increased blood pressure.
Allergic reactions: skin rash, bronchospasm.
Others: chills, swelling of limbs, photosensitization; rarely - a change in the pattern of peripheral blood, renal dysfunction.
Interaction with other drugs
With the simultaneous use of dexketoprofen with other NSAIDs may increase the risk of side effects.
With simultaneous use with lithium preparations may increase the concentration of the latter in the blood plasma.
Use dexketoprofen with caution in less than 24 hours before the start of application or after the end of therapy with methotrexate, since the plasma concentration of the latter (and, consequently, toxicity) may increase.
Separate cases of bleeding with the simultaneous use of NSAIDs and anticoagulants are described.
special instructions
Care should be taken when prescribing the drug to elderly patients, patients with allergic reactions, systemic connective tissue diseases and patients with impaired blood formation.
It is necessary to inform patients that in the event of side effects, as well as in the absence of clinical effect, it is necessary to inform the attending physician within 3-5 days of treatment.
Special care is required with simultaneous use of dexketoprofen with phenytoin, sulfonamides, and drugs that reduce blood clotting.
Influence on ability to drive motor transport and control mechanisms
Since dexketoprofen can cause a decrease in the ability to concentrate, it should be used with caution in patients engaged in potentially hazardous activities that require increased attention and quickness of psychomotor reactions.