Hemomycin powder for suspension 200mg 5ml vial 10g
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Active ingredients
Azithromycin
Release form
Powder
Composition
Active ingredient: Azithromycin (Azithromycinum) Active ingredient concentration (mg): 200
Pharmacological effect
Broad-spectrum antibiotic. Azithromycin is a representative of the macrolide antibiotic subgroup - azalides. It has a bactericidal effect in high concentrations. Hemomycin is active against aerobic gram-positive bacteria: Streptococcus pneumoniae, Streptococcus pyogenes, Streptococcus agalactiae, Streptococcus spp. groups C, F and G, Streptococcus viridans, Staphylococcus aureus; Aerobic Gram-negative bacteria: Haemophilus influenzae, Moraxella catarrhalis, Bordetella pertussis, Bordetella parapertussis, Legionella pneumophila, Haemophilus ducreyi, Helicobacter pylori, Campylobacter jejuni, Neisseria gonor rh o rr o syrhacrus, pylori pylori, neyseroslae neyserophylus pylori, Helicobacter pylori Anaerobic Bacterium
Pharmacokinetics
Asythromycin is rapidly absorbed from the gastrointestinal tract, due to its stability in an acidic environment and lipophilicity. After ingestion of Hemomycin in the dose of 500 mg of azithromycin Cmax in the blood plasma is achieved in 2.5-2.96 hours and is 0.4 mg / l. Bioavailability is 37%. DistributionAzithromycin penetrates well into the respiratory tract, organs and tissues of the urogenital tract, into the prostate gland, into the skin and soft tissues. High tissue concentrations (10–50 times higher than in plasma) and prolonged T1 / 2 are due to the low binding of azithromycin to plasma proteins, as well as its ability to penetrate into eukaryotic cells and concentrate in a low pH environment surrounding the lysosomes. This, in turn, determines a large apparent Vd (31.1 l / kg) and high plasma clearance. The ability of azithromycin to accumulate primarily in lysosomes is especially important for the elimination of intracellular pathogens. It has been proven that phagocytes deliver azithromycin to the site of infection, where it is released during phagocytosis. The concentration of azithromycin in the foci of infection is significantly higher than in healthy tissues (by an average of 24–34%) and correlates with the degree of inflammatory edema. Despite the high concentration in phagocytes, azithromycin does not significantly affect their function. Azithromycin remains in bactericidal concentrations in the focus of inflammation for 5-7 days after the last dose,which allowed developing short (3-day and 5-day) courses of treatment. Metabolism In the liver, azithromycin is demethylated, the resulting metabolites are not active. Excretion The removal of azithromycin from blood plasma takes place in 2 stages: T1 / 2 is 14-20 hours in the range from 8 to 24 hours after taking the drug and 41 hours in the range from 24 to 72 hours, which allows you to use the drug 1 time / day.
Indications
Infectious and inflammatory diseases caused by microorganisms sensitive to the drug: infections of the upper respiratory tract and upper respiratory tract (tonsillitis, sinusitis, tonsillitis, pharyngitis, otitis media), scarlet fever, infections of the lower respiratory tract (bacterial and atypical pneumonia, bronchitis), infections skin and soft tissues (erysipelas, impetigo, secondarily infected dermatosis), Lyme disease (borreliosis), for the treatment of the initial stage (erythema migrans).
Contraindications
Hypersensitivity (including to other macrolides); hepatic and / or renal failure; lactation period; children up to 12 months.
Precautionary measures
The drug should be prescribed with caution during pregnancy, with arrhythmias (ventricular arrhythmias and prolongation of the QT interval are possible) in children with severe impaired liver function or kidney problems.
Use during pregnancy and lactation
In pregnancy, Hemomycin is prescribed only when the expected benefit of therapy for the mother outweighs the potential risk to the fetus. If necessary, use of the drug during lactation should decide whether to stop breastfeeding for the duration of the drug.
Dosage and administration
The drug is taken orally once a day, 1 hour before meals or 2 hours after meals. Water (distilled or boiled and cooled) is added to the vial to the mark. The contents of the vial are thoroughly shaken until a homogeneous suspension is obtained. If the level of the prepared suspension is below the label on the bottle label, re-add water to the label and shake. The prepared suspension is stable at room temperature for 5 days. In infections of the upper and lower respiratory tract, skin and soft tissues (except for chronic migrating erythema), the drug is prescribed for children at a dose of 10 mg / kg of body weight once a day for 3 days. Suspension of this dosage is recommended for use in children over 12 months .Depending on the body weight of the child, the following dosing regimen is recommended: Body weight of the patient Daily dose (suspension 200 mg / 5 ml) 10-14 kg 2.5 ml (100 mg) - 1/2 spoon 15-25 kg 5 ml (200 mg) - 1 teaspoon 26-35 kg 7.5 ml (300 mg) - 1.5 spoons 36-45 kg 10 ml (400 mg) - 2 spoons more than 45 kg administered doses for adults In adults with upper and lower respiratory tract infections, 500 mg are administered 1 time per day. for 3 days (course dose 1.5 g); with infections of the skin, soft tissues, as well as Lyme disease (borreliosis) for the treatment of the initial stage (erythema migrans) - 1 g per day on the first day for 1 dose, then 0.5 g per day every day from 2 to 5 days ( course dose - 3 g). In case of chronic migrating erythema - 1 time per day for 5 days: on the 1st day in a dose of 20 mg / kg body weight, and then from the 2nd to the 5th day - 10 mg each / kg of body weight. The following dosing regimen of Chemomycin drug in children with Erythema migrans is recommended: Day 1 Body weight Daily dose (suspension 200 mg / 5 ml) 8-14 kg 5 ml (200 mg) -1 spoon 15-24 kg 10 ml (400 mg) -2 l gels 25-44 kg 12.5 ml (500 mg) -2.5 spoons From the 2nd to the 5th day Body weight Daily dose (suspension 200 mg / 5 ml) 8-14 kg 2.5 ml (100 mg) -1 / 2 spoons15-24 kg 5 ml (200 mg) -1 spoon 25-44 kg 6.25 ml (250 mg) -1.25 spoons Shake before use! Immediately after taking the suspension, the child should be given a few sips of liquid (water, tea) in order to wash off and swallow the remaining suspension in the oral cavity. In case the dose of the drug was missed, it should be taken as soon as possible and then subsequent doses should be taken at intervals of 24 hours.
Side effects
On the part of the gastrointestinal tract: diarrhea (5%), nausea (3%), abdominal pain (3%); 1% or less - dyspepsia (flatulence, vomiting), melena, cholestatic jaundice, increased activity of hepatic transaminases; children have constipation, anorexia, gastritis. Since the cardiovascular system: palpitations, chest pain (1% or less). From the nervous system: dizziness, headache, drowsiness; in children - headache (with otitis media therapy), hyperkinesia, anxiety, neurosis, sleep disturbance (1% or less). From the urogenital system: vaginal candidiasis, nephritis (1% or less). Allergic reactions: rash, angioedema, in children - conjunctivitis, pruritus, urticaria. Others: increased fatigue; photosensitization.
Overdose
Symptoms: nausea, temporary hearing loss, vomiting, diarrhea. Treatment: gastric lavage, conducting symptomatic therapy.
Interaction with other drugs
With simultaneous use of Hemomycin and antacids (aluminum and magnesium), azithromycin absorption is slowed down. Ethanol and food slow down and reduce azithromycin absorption. When co-administered with warfarin and azithromycin (in usual doses), there are no changes in prothrombin time, however, given that warfarin may increase the anticoagulant effect, patients need careful control of prothrombin time. The combined use of azithromycin and digoxin increases the concentration After the simultaneous use of Azithromycin, you can enjoy an increase in the toxicity of the latter to help you to enhance the effect of the company. , felodipine, as well as drugs undergoing microsomal oxidation (carbamazepine, terfenadine, cyclos porhane, hexaboles azithromycin is incompatible with heparin.
special instructions
You should not take the drug during a meal. It is recommended that the interval of at least 2 hours between taking Hemomycin and antacid drugs. After discontinuation of treatment, some patients may persist hypersensitivity reactions, which requires specific therapy and medical control.