Clopixol depot solution for oil in 200mg ml
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Active ingredients
Zuclopentixol
Release form
Solution
Composition
1 ml of zuclopentixol decanoate 200 mg. Excipients: sodium chloride, hydrochloric acid or sodium hydroxide (to adjust the pH), water d / and.
Pharmacological effect
Antipsychotic (neuroleptic), a derivative of thioxanthene. It is believed that the antipsychotic action of zuclopentixol is due to the blockade of dopamine receptors in the CNS. Thioxanthene derivatives have high affinity for the dopamine D1 and D2 receptors. Zuclopentixol causes a fast, transient, dose-dependent sedative effect, prior to the development of antipsychotic action. Unlike zuclopentixol hydrochloride, zuclopentixol acetate has a longer duration of action - 2-3 days, and zuclopentixol decanoate is a depot form and its effect lasts for 2-4 weeks.
Indications
For oral administration: the manic phase of a manic-depressive psychosis, mental retardation in conjunction with psychomotor agitation, agitation and other behavioral disorders. senile dementia with paranoid ideas, confusion, disorientation, behavior disorders. For intramuscular administration: initial treatment of acute psychosis, manic states and chronic psychosis in the acute phase. For intramuscular injection of the depot form: maintenance therapy for schizophrenia and paranoid psychosis.
Contraindications
Acute overdose of barbiturates, opioid receptor agonists, acute alcohol intoxication, coma, hypersensitivity to zuclopentyxol.
Use during pregnancy and lactation
Use during pregnancy and lactation is not recommended. Low concentrations of zuclopentixol are found in breast milk.
Dosage and administration
Dose, frequency and duration of use depend on the evidence, used dosage form and treatment regimen. For oral administration, the initial dose may be 2-20 mg / day. if necessary, a gradual increase in the dose up to 75 mg / day or more is possible. For intramuscular administration of a single dose - 50-150 mg, in case of need for repeated injections, the interval between them should be 2-3 days.For intramuscular administration of the depot form, a single dose is 200-750 mg, the frequency of administration is 1-4 weeks and is determined by the clinical situation.
Side effects
On the part of the central nervous system: dizziness, drowsiness (especially when using the drug in high doses and at the beginning of treatment), the development of extrapyramidal disorders (mainly at the beginning of treatment), accommodation disorder. rarely, with prolonged therapy - tardive dyskinesia. Since the cardiovascular system: tachycardia, orthostatic hypotension. On the part of the digestive system: dry mouth, constipation, rarely - minor transient changes in liver samples. On the part of the urinary system: urinary retention.
special instructions
On the part of the central nervous system: dizziness, drowsiness (especially when using the drug in high doses and at the beginning of treatment), the development of extrapyramidal disorders (mainly at the beginning of treatment), accommodation disorder. rarely, with prolonged therapy - tardive dyskinesia. Since the cardiovascular system: tachycardia, orthostatic hypotension. On the part of the digestive system: dry mouth, constipation, rarely - minor transient changes in liver samples. On the part of the urinary system: urinary retention.