Quetiapine pills 100 mg 60 pcs
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Description
Composition Quetiapine 100 mg Pharmacological action Antipsychotic agent (neuroleptic). Shows higher affinity for serotonin 5HT2 receptors, compared with dopamine D1 and D2 receptors in the brain. It also has a high affinity for histamine and .1 receptors and less pronounced for the .2 receptors. Does not possess affinity to m-cholinergic receptors and benzodiazepine receptors. Quetiapine at a dose that effectively blocks dopamine D2 receptors causes only weak catalepsy. Selectively reduces the activity of mesolimbic A10-dopamine neurons compared to A9 nigrostriatal neurons involved in motor function. Does not cause prolonged increase in prolactin levels. According to the positron emission tomography results, quetiapine acts on serotonin 5HT2 and dopamine D2 receptors for up to 12 hours.
Dosage and administration
When used in adults, the initial dose is 50 mg / day, for elderly patients - 25 mg / day. Then the dose is gradually increased according to the scheme. Depending on the clinical effect and individual sensitivity, the effective therapeutic dose may be 150-750 mg / day. In patients with impaired liver and / or kidney function, the initial dose is 25 mg / day. Daily dose increases should be 25-50 mg to achieve optimal effect. Precautions During the period of treatment may worsen psoriasis. With pheochromocytoma, propranolol can be used only after taking an alpha blocker. After a long course of treatment, propranolol should be discontinued gradually, under the supervision of a physician. Against the background of treatment with propranolol, IV administration of verapamil, diltiazem should be avoided. A few days before anesthesia, you must stop taking propranolol or pick up a remedy for anesthesia with minimal negative inotropic effects. Influence on the ability to drive vehicles and control mechanisms In patients whose activities require increased attention, the question of the use of propranolol on an outpatient basis should be addressed only after evaluating the individual response of the patient. Side effect From the side of the central nervous system: headache, drowsiness, dizziness, anxiety. rarely - ZNS.Since the cardiovascular system: orthostatic hypotension, tachycardia, arterial hypertension. On the part of the digestive system: constipation, dry mouth, dyspepsia, diarrhea, transient increase in liver enzymes (ALT, AST, GGT), abdominal pain. From the side of blood-forming organs: asymptomatic leukopenia and / or neutropenia. rarely eosinophilia. From the musculoskeletal system: myalgia. On the part of the respiratory system: rhinitis. Dermatological reactions: skin rash, dry skin. On the part of the organ of hearing: pain in the ear. On the part of the urogenital system: urinary tract infections. On the part of metabolism: a slight increase in cholesterol and triglycerides in the blood. On the part of the endocrine system: a small dose-dependent reversible decrease in the level of thyroid hormones (in particular, total and free T4). Other: asthenia, back pain, weight gain, fever, chest pain. Cautions Use with caution in patients with cardiovascular diseases and other conditions associated with the risk of arterial hypotension, especially at the beginning of treatment and in the elderly. with indications of a history of seizures. Quetiapine undergoes active metabolism in the liver. In patients with impaired liver and kidney function, the clearance of quetiapine is reduced by approximately 25%. Therefore, quetiapine should be used with caution in patients with impaired liver and / or kidney function. With caution used simultaneously with drugs that extend the QT interval (especially in the elderly). with drugs that have a depressant effect on the central nervous system, as well as with ethanol. with potential inhibitors of an isoenzyme CYP3A4 (including with ketoconazole, erythromycin). With the development during treatment with ZNS, quetiapine should be canceled and appropriate treatment should be prescribed. With prolonged use, there is a likelihood of tardive dyskinesia. In such cases, you must reduce the dose of quetiapine or cancel it. To be used with caution in combination with other drugs that affect the activity of the central nervous system, as well as with ethanol. In experimental studies of the carcinogenicity of quetiapine, there was an increase in the incidence of breast adenocarcinomas in rats (at doses of 20, 75 and 250 mg / kg / day), which is associated with prolonged hyperprolactinemia.In male rats (250 mg / kg / day) and mice (250 and 750 mg / kg / day), there was an increase in the incidence of benign thyroid follicular cell adenomas, which was associated with the known rodent-specific mechanism for increasing thyroid clearance of thyroxine. Influence on the ability to drive vehicles and control mechanisms Quetiapine can cause drowsiness, so patients are not recommended to perform work associated with the need for concentration and high speed psychomotor reactions (including driving). Use during pregnancy and breastfeeding. During pregnancy and lactation, use is possible in cases where the expected benefit to the mother outweighs the potential risk to the fetus. It is not known whether quetiapine is excreted in breast milk. If necessary, use during lactation breastfeeding should be discontinued. In experimental animal studies, no mutagenic and clastogenic effects of quetiapine were detected. No effect of quetiapine on fertility (reduced male fertility, pseudo-pregnancy, an increase in the period between two estrus, an increase in the precoital interval, and a decrease in the frequency of pregnancy), but the data obtained cannot be directly transferred to a person, because There are specific differences in the hormonal control of reproduction. Type: Medicine Quantity in the package, pcs: 60 Shelf life: 24 months Active ingredient: Quetiapine (Quetiapine) Route of administration: Oral Vacation procedure: Prescription Release form: Prescription Storage conditions: In a dry place, In a dark place, Keep out of reach of children Maximum storage temperature, ° С: 25 Pharmacological group: N05AH Derivatives of diazepine, thiazepine and oxazepine Minimum age: 18 yearsActive ingredients
Quetiapine
Release form
Pills
Composition
Quetiapine 100 mg
Pharmacological effect
Antipsychotic (neuroleptic). Shows higher affinity for serotonin 5HT2 receptors, compared with dopamine D1 and D2 receptors in the brain. It also has a high affinity for histamine and & # 945 .1 receptors and less pronounced for & # 945 .2 receptors. Does not possess affinity to m-cholinergic receptors and benzodiazepine receptors.Quetiapine at a dose that effectively blocks dopamine D2 receptors causes only weak catalepsy. Selectively reduces the activity of mesolimbic A10-dopamine neurons compared to A9 nigrostriatal neurons involved in motor function. Does not cause prolonged increase in prolactin levels. In accordance with the results of positron emission tomography, the effect of quetiapine on serotonin 5HT2 and dopamine D2 receptors lasts up to 12 hours.
Indications
Acute and chronic psychoses (including schizophrenia).
Contraindications
Hypersensitivity to quetiapine.
Use during pregnancy and lactation
In pregnancy and lactation, use is possible in cases where the expected benefit to the mother outweighs the potential risk to the fetus. It is not known whether quetiapine is excreted in breast milk. If necessary, use during lactation breastfeeding should be discontinued. In experimental animal studies, no mutagenic and clastogenic effects of quetiapine were detected. No effect of quetiapine on fertility (reduced male fertility, pseudo-pregnancy, an increase in the period between two estrus, an increase in the precoital interval, and a decrease in the frequency of pregnancy), but the data obtained cannot be directly transferred to a person, because There are specific differences in the hormonal control of reproduction.
Dosage and administration
When used in adults, the initial dose is 50 mg / day, for elderly patients - 25 mg / day. Then the dose is gradually increased according to the scheme. Depending on the clinical effect and individual sensitivity, the effective therapeutic dose may be 150-750 mg / day. In patients with impaired liver and / or kidney function, the initial dose is 25 mg / day. Daily dose increases should be 25-50 mg to achieve optimal effect.
Side effects
From the side of the central nervous system: headache, drowsiness, dizziness, anxiety. rarely - ZNS. Since the cardiovascular system: orthostatic hypotension, tachycardia, arterial hypertension. On the part of the digestive system: constipation, dry mouth, dyspepsia, diarrhea, transient increase in liver enzymes (ALT, AST, GGT), abdominal pain.From the side of blood-forming organs: asymptomatic leukopenia and / or neutropenia. rarely eosinophilia. From the musculoskeletal system: myalgia. On the part of the respiratory system: rhinitis. Dermatological reactions: skin rash, dry skin. On the part of the organ of hearing: pain in the ear. On the part of the urogenital system: urinary tract infections. On the part of metabolism: a slight increase in cholesterol and triglycerides in the blood. On the part of the endocrine system: a small dose-dependent reversible decrease in the level of thyroid hormones (in particular, total and free T4). Other: asthenia, back pain, weight gain, fever, chest pain.
special instructions
From the side of the central nervous system: headache, drowsiness, dizziness, anxiety. rarely - ZNS. Since the cardiovascular system: orthostatic hypotension, tachycardia, arterial hypertension. On the part of the digestive system: constipation, dry mouth, dyspepsia, diarrhea, transient increase in liver enzymes (ALT, AST, GGT), abdominal pain. From the side of blood-forming organs: asymptomatic leukopenia and / or neutropenia. rarely eosinophilia. From the musculoskeletal system: myalgia. On the part of the respiratory system: rhinitis. Dermatological reactions: skin rash, dry skin. On the part of the organ of hearing: pain in the ear. On the part of the urogenital system: urinary tract infections. On the part of metabolism: a slight increase in cholesterol and triglycerides in the blood. On the part of the endocrine system: a small dose-dependent reversible decrease in the level of thyroid hormones (in particular, total and free T4). Other: asthenia, back pain, weight gain, fever, chest pain.