Tarivid pills 200 mg 10 pcs
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Active ingredients
Ofloxacin
Release form
Pills
Composition
1 tablet contains: 200 Floksatsin mgVspomogatelnye substances: lactose, starch, giproloza (hydroxypropyl cellulose), carmellose (carboxymethylcellulose), magnesium stearate, hypromellose (hydroxypropylmethyl cellulose), Macrogol (polyethylene glycol) 8000, titanium dioxide (E171), talc.
Pharmacological effect
Antimicrobial drug from the group of fluoroquinolones with a wide spectrum of action. Bactericidal effect. The mechanism of action of ofloxacin is associated with the blockade of the DNA gyrase enzyme in bacterial cells. It is highly active against most gram-negative and some gram-positive microorganisms: Aeromonas hydrophila, Branhamella catarrhalis, Brucella spp., Clostridium perfringens, Esherichia coli, Salraelae, an anthramlae, an anthramlamela, an anthramla, an anthracidus, Brucella spp. ., Citrobacter spp, Yersinia spp, Providencia spp, Haemophilus influenzae and parainfluenzae, Haemophilus ducreyi, Plesiomonas, Legionella, Shigella spp, Proteus spp, including Proteus mirabilis, Proteus vulgaris (indole + and indole -)....., Moraxella morganii Klebsiella spp., Including Klebsiella pneumoniae, Helicobacter pylori, Mycoplasma spp., Vibrio spp., Gardnerella vaginalis. Neisseria gonorrhoeae, Neisseria meningitidis, Chlamydia trachomatis, Staphylococcus aureus methi-S, Staphylococcus coagulase negative. Moderately sensitive to ofloxacin Acinetobacter spp., Ureaplasma urealyticum, Bacteroides fragilis, Mycobacterium tuberculosis, Mycobacterium leprae, Chlamidia psittaci, anaerobic gram-positive cocci, Enterococcus faecalis, Streptococcus pneumoniae, Pseudomonas spp, Streptococcus spp. (especially beta-hemolytic). To ofloxacin insensitive Acinetobacter braumanmii, Clostridium difficile, Enterococci, Listeria monocytogenes, Staphylococci methi-R, Nocardia spp..Ofloxacin is inactive against Treponema pallidum.
Pharmacokinetics
After oral administration, ofloxacin is rapidly and almost completely absorbed from the gastrointestinal tract. Bioavailability is almost 100%. Cmax of ofloxacin in the blood plasma after taking a single dose of 200 mg is 2.5-3 μg / ml and is achieved after 1 h. Binding to plasma proteins is 25%. About 5% of ofloxacin is metabolized. T1 / 2 - 6-7 h. Vd is about 120 l. Up to 90% of ofloxacin is excreted by the kidneys unchanged, about 4% with bile.
Indications
Treatment of infectious and inflammatory diseases caused by microorganisms that are sensitive to ofloxacin: - respiratory tract infections (except for cases of pneumococcal infection); - ear, throat, nose infections (except for acute tonsillitis); - infections of the abdominal cavity and biliary tract; - kidney infections , urinary tract, prostate gland, urethra (including gonococcal nature); - infections of the pelvic organs; - infections of bones and joints; - infections of the skin and soft tissues; - prevention of infections in patients with impaired immunity unnogo status (including with neutropenia).
Contraindications
- epilepsy; - lesions of the central nervous system with a reduced seizure threshold (after traumatic brain injury, stroke,inflammation in the central nervous system (CNS); tendon lesions during previous treatment with quinolones; age up to 18 years; pregnancy and lactation; hypersensitivity to ofloxacin, other quinolones or components of the drug.
Precautionary measures
With care: in patients with atherosclerosis of cerebral vessels, impaired blood circulation (in history), chronic renal failure, organic lesions of the central nervous system, with prolongation of the QT interval.
Use during pregnancy and lactation
Contraindicated in pregnancy and lactation
Dosage and administration
Inside. The dose of ofloxacin and the duration of treatment depend on the severity and type of infection, the patient's general condition and kidney function. The average daily dose for adults is from 200 mg to 600 mg. The duration of treatment is 7-10 days. A dose of up to 400 mg / day can be prescribed in one dose, preferably in the morning. Doses above 400 mg / day should be divided into 2 doses with an equal period of time. Tablets should be taken whole, washed down with water, both before and during meals. It is necessary to avoid concurrent use with antacids. In severe infections or in the treatment of overweight patients, the daily dose may be increased to 800 mg. In uncomplicated infections of the lower urinary tract, the drug is prescribed at a dose of 200 mg / day for 3-5 days. gonorrhea is prescribed 400 mg once. In patients with impaired renal function, the dose should be reduced depending on creatinine clearance. In patients with hepatic insufficiency, it is not recommended to exceed the maximum daily dose of 400 mg. Treatment of ofloxacin can be continued with a tablet form of the drug in the same dose (while improving the patient's condition).
Side effects
Selected cases: • Anaphylactic / anaphylactoid reactions, skin and mucous reactions. Frequently encountered: Rare: Symptoms, such as: itching, rash, burning eyes, dry cough, rhinitis. / bronchospasm; hyperemia, sweating, papular rash. Anaphylactic / anaphylactoid shock, erythema multiforme exudative, toxic epidermal necrolysis, photosensitivity,persistent drug rash, vascular purpura, bullous hemorrhagic dermatitis, punctate hemorrhages, vasculitis, which in exceptional cases can lead to skin necrosis. in the stomach, diarrhea, nausea, vomiting, loss of appetite, Occurring: Rare: Anorexia, flatulence, enterocolitis, which may in some cases be hemorrhagic. Very rare: Pseudomembranous colitis. • NeurologicStimulation, dizziness, headache, sleep disturbances / insomnia. Psychotic reactions (eg, hallucinations), anxiety, confusion, intense or “nightmarish” dreams, depression, drowsiness, disturbances of peripheral sensitivity, such as paresthesia, disorders of taste and smell, color disturbance, diplopia. Hearing disorders, such as tinnitus or hearing loss, epileptic seizures, extrapyramidal disorders or other muscle coordination disorders, hypesthesia, tremor, convulsions. Psychotic reactions accompanied by patient-threatening behavior, including suicidal tendencies, increased intracranial pressure. Cardiovascular Decrease blood pressure, tachycardia. MusculoskeletalRare: Tendonitis. Very rare: arthralgia, myalgia. Tendon rupture (ie, Achilles tendon); as with other fluoroquinolones, this side effect can be observed within 48 hours after the start of treatment and can be bilateral. Separate Rhabdomyolysis (acute necrosis of skeletal muscles) and / or myopathy. Case: Muscle weakness, which can be especially important in patients with severe pseudoparalytic myasthenia. • From the side of the liver. Cholestatic jaundice. Hepatitis, which can be severe. Rare: Enhancement of liver enzymes (ACT, ALT, LDH, GTT and / or alkaline phosphatase) and / or bilirubin. tion sistemyGiperkreatinemiya, increasing concentrations of urea. Acute renal failure. Interstitial nephritis. Anemia, hemolytic anemia, leukopenia, eosinophilia, thrombocytopenia. Agranulocytosis, pancytopenia, inhibition of bone marrow hematopoiesis. Development of secondary infection,caused by drug-resistant microorganisms and fungi. Acute attacks of porphyria in patients with porphyria, vaginitis, intestinal dysbacteriosis, hypoglycemia in patients with diabetes mellitus treated with hypoglycemic drugs.
Overdose
The most important symptoms of an overdose are symptoms of the central nervous system: dizziness, confusion, lethargy, disorientation, drowsiness, and reactions from the gastrointestinal tract: vomiting. In case of overdose, gastric lavage is recommended (applies to pills) and symptomatic therapy. There is no specific antidote.
Interaction with other drugs
Antacids containing aluminum hydroxide (including sucralfate) and magnesium, aluminum phosphate, zinc, iron reduce the absorption of ofloxacin. When taking antacids and ofloxacin between their intake should be observed approximately two-hour interval. When using vitamin K antagonists at the same time, control of the blood coagulation system is necessary. Ofloksacin may slightly increase the serum concentrations of glibenclamide while using it. with the help of renal tubular secretion, such as probenicide, cimetidine, furosemide or methotrexate, it is possible to increase of serum concentration of ofloxacin. In clinical studies, no pharmacokinetic interaction of ofloxacin with theophylline was detected. However, a noticeable lowering of the threshold of convulsive activity could be observed when quinolones were prescribed in combination with theophylline, fenbufen or other nonsteroidal anti-inflammatory drugs, as well as other drugs that lower the threshold of seizure activity. neurotoxic effects. When administered simultaneously with glucocorticosteroids, the risk of tendon rupture increases, In the case of co-administration with drugs extending the QT interval (IA and III classes of antiarrhythmic drugs, tricyclic antidepressants, macrolides) the risk of prolonging the QT interval increases. increases the risk of crystalluria and nephrotoxic effects.
special instructions
Renal failure Due to the fact that ofloxacin is excreted mainly through the kidneys, dose adjustment of ofloxacin is necessary in patients with renal insufficiency. Prevention of photosensitization During treatment with ofloxacin, due to the risk of photosensitization, exposure to bright sunlight and ultraviolet rays should be avoided. Secondary infection As When treating with other antibiotics, taking ofloxacin, especially long-lasting, may cause a secondary infection associated with the growth of drug-resistant m microorganisms. Re-evaluation of the patient’s condition is necessary. If a secondary infection occurs during therapy, appropriate measures should be taken. Pseudomembranous colitisDifferent diarrhea, especially in severe form, persistent and / or mixed with blood, during or after treatment with ofloxacin may be a manifestation of pseudomembranous colitis. If pseudomembranous colitis is suspected, treatment with ofloxacin should be immediately discontinued, and appropriate specific antibiotic therapy (for example, oral vayakamitsin, oral teykoplanin or metronidazole) should be immediately appointed. In this clinical situation, drugs that suppress intestinal peristalsis are contraindicated. Patients predisposed to the occurrence of epileptic seizures or drugs that lower the threshold of seizure activity, for example, theophylline). Tendonitis Tendinitis, which occurs very rarely, can sometimes lead to tendon rupture, mainly Achilles tendon, especially in elderly patients. In case of signs of tendinitis (inflammation of the tendon), it is recommended to immediately stop treatment, immobilize the Achilles tendon and provide consultation to the orthopedist. old age; - uncorrectable electrolyte imbalance (for example,hypokalemia, hypomagnesemia); - congenital lengthening of the QT interval; - diseases of the cardiovascular system (heart failure, myocardial infarction, bradycardia) - concurrent use of drugs that prolong the QT interval (IA and III classes of antiarrhythmic drugs, tricyclic antidepressants, macrolides). lead to the deterioration of the course of myasthenia. Porphyria. There may be an increase in attacks of porphyria. During treatment with ofloxacin, false positive results may appear in the determination of opiates and porphyrins in the urine. Others Ofloxacin interferes with the secretion of Mycobacterium tuberculosis, leading to false-negative results in bacteriological diagnosis of tuberculosis. Also, it is not recommended to use hygiene in bacteriological diagnostics of tuberculosis. due to an increased risk of developing thrush. Ofloxacin is not the drug of choice for pneumonia caused by pneumonia. cocci. Not indicated in the treatment of acute tonsillitis. Effects on the ability to drive vehicles and control mechanisms. Some adverse reactions, such as dizziness, drowsiness and visual disturbances may reduce the response and ability to concentrate and therefore increase the risk in situations where these abilities are particularly important (for example when driving a car or other mechanisms).