Teopek retard pills 100mg N50
Condition: New product
1000 Items
Rating:
Be the first to write a review!
More info
Active ingredients
Theophylline
Release form
Pills
Composition
Theophylline 100 mg; Auxiliary substances: Composite polymer carrier (polymethacrylic acid and macrogol (polyethylene glycol) interpolymer complex), calcium stearate.
Pharmacological effect
Teopek (Theophylline) refers to phosphodiesterase inhibitors .; Theophylline increases accumulation in the tissues of c-AMP, which reduces the contractile activity of the smooth muscles. Theophylline expands the bronchi, blood vessels (mainly the brain, skin and kidney vessels); Reduces pulmonary vascular resistance, lowers pressure in the small circulation,. Increases kidney circulation. blood flow.; It has a moderate diuretic effect.; Inhibits platelet aggregation.; It has a stimulating effect on the respiratory center, increases the frequency and strength of heart contractions .; Slow release of the active substance from the pill ensures the achievement of the therapeutic level of theophylline in the blood 3-5 hours after taking Teopac and lasts for 10-12 hours .; Two times the drug allows you to get effective concentrations of theophylline in the blood during the day .; In connection with the action of the drug, one of the important indicators to use is the prevention of night and pre-morning effects of bronchospasm.
Pharmacokinetics
When ingested, theophylline is rapidly and completely absorbed from the gastrointestinal tract. The presence of food in the stomach can affect the rate (but not the degree) of theophylline absorption, as well as its clearance. When using the dosage form of the usual duration of action Cmax in plasma is achieved in 1-2 hours; After i / m injection, absorption is slow and incomplete.; Plasma protein binding is approximately 40%; Plasma protein binding is approximately 40%; in newborns, as well as in adults with diseases, the binding is reduced.; Theophylline is metabolized in the liver with the participation of several cytochrome P450 isoenzymes, the most important of which is CYP1A2. In the process of metabolism 1,3-dimethyl uric acid, 1-methyl uric acid and 3 methylxanthine are formed. These metabolites are excreted in the urine. Unchanged in adults is 10%. In newborns, a significant part is excreted in the form of caffeine (due to the immaturity of the pathways of its further metabolism), unchanged - 50%; Significant individual differences in theophylline hepatic metabolism rate cause a pronounced variability of clearance values, plasma concentrations, T1 / 2.The hepatic metabolism is influenced by such factors as age, addiction to tobacco smoking, diet, diseases, and simultaneously conducted drug therapy. Theofillin T1 / 2 in non-smoking patients with bronchial asthma with virtually no pathological changes from other organs and systems is 6-12 hours, in children - 1-5 hours, in smokers - 4-5 hours, in newborns and premature babies - 10-45 hours; T1 / 2 of theophylline is increased in the elderly and in patients with heart failure or liver disease.; The clearance decreases with heart edostatochnosti, hepatic dysfunction, chronic alcoholism, pulmonary edema, in patients with COPD.
Indications
Treatment and prevention of broncho-obstructive syndrome in: - Bronchial asthma.; - Chronic obstructive bronchitis.; - Emphysema of the lungs.; - Dermato-respiratory syndrome.; - Other respiratory diseases.
Contraindications
- Hypersensitivity (including to other xanthine derivatives - caffeine, pentoxifylline, theobromine); - Acute myocardial infarction. - Severe hypertension or hypotension; - Common vascular atherosclerosis. - Serious cardiac rhythm disturbances (severe tachyhariarity (severe , extrasystole).; - Hyperfunction of the thyroid gland.; - Peptic ulcer of the stomach and duodenum in the acute stage.; - Gastritis with increased acidity.; - Bleeding from the gastrointestinal tract.; - Epilepsy.; - Increased seizure activity. - Hemorrhagic sky stroke; -. Bleeding in the retina of the eye -. Pregnancy -. Children under 3 years of age .; Use with caution in: - Severe angina.; - Heart failure.; - Hypertrophic cardiomyopathy.; - Severe impaired liver and kidney function. - Gastric ulcer and duodenal ulcer (in anamnesis); - Bleeding from the gastrointestinal tract in recent history.; - Prolonged hyperthermia.; - Gastroesophageal reflux.; - Prostate hypertrophy.
Use during pregnancy and lactation
Theophylline penetrates the placental barrier, is excreted in breast milk.; During pregnancy, theophylline is used only if the intended benefit to the mother outweighs the possible risk to the fetus.; If necessary, use during lactation it should be noted that theophylline is excreted in breast milk.
Dosage and administration
Teopek used inside after a meal, drinking water. The tablet is not crushed, chewed or dissolved in water .; The daily dose is divided into 2 doses with an interval of 12 hours; The optimal dose is selected individually, depending on the nature of the disease, the age and weight of the patient .; The drug is prescribed 2 times a day: - Adults and children over 14 years old, 300 mg., - Children from 7 to 12 years old - 200 mg each. On the first day, treatment begins with half the daily dose in 2 doses. In the absence of adverse reactions, switch to the full daily dose .; The duration of the drug depends on the characteristics of the course of the disease and therapeutic effect.; On average, a course of treatment can last from 2 weeks to 2 months.
Overdose
Symptoms: loss of appetite, gastralgia, diarrhea, nausea, vomiting (including blood), gastrointestinal bleeding, tachypnea, flushing of the skin of the face, tachycardia, ventricular arrhythmias, insomnia, motor agitation, anxiety, photophobia, tremor, convulsions . When severe poisoning may develop epileptoid seizures, hypoxia, metabolic acidosis, hyperglycemia, hypokalemia, lower blood pressure, confusion, renal failure with myoglobinuria.; Treatment: removal of the drug, gastric lavage, the appointment of activated charcoal, laxatives, intestinal washing with a combination of polyethylene glycol and electrolytes, forced diuresis, hemosorption, plasma adsorption, hemodialysis (not effective, peritoneal dialysis is not effective), symptomatic therapy (Including metoclopramide and ondansetron - vomiting). In the event of seizures, maintain airway and pass oxygen therapy. For the relief of seizure - in / in diazepam, 0.1-0.3 mg / kg (but not more than 10 mg). With severe nausea and vomiting - metoclopramide or ondansetron (IV).
Interaction with other drugs
Theophylline is not used in conjunction with other xanthine derivatives .; In combination with phenobarbital, difenin, rifampicin, isoniazid, carbamazepine, sulfinpyrazone, phenytoin, there is a decrease in theophylline efficacy, which may require an increase in the used doses of the drug .; With simultaneous use with macrolide antibiotics, lincomycin,allopurinol, cimetidine, isoprenaline, beta-blockers, oral contraceptives, epoxacin, and during influenza vaccination, the intensity of action may increase, which may require lowering theophylline dose .; Theophylline increases the likelihood of side effects of glucocorticosteroids, mineralocorticosteroids (hypernatremia), agents that excite the central nervous system (increases neurotoxicity) .; The drug inhibits the therapeutic effects of lithium carbonate and beta-blockers .; Theophylline potentiates the action of diuretics by increasing glomerular filtration and reducing tubular reabsorption .; With caution, theophylline is prescribed simultaneously with anticoagulants .; Antidiarrheal drugs and enterosorbents reduce theophylline absorption.
special instructions
In severe diseases of the cardiovascular system, liver, viral infections, as well as in elderly patients, the dose should be reduced .; The effectiveness of theophylline may be reduced in smokers .; Since the bronchodilator effect of Teopac develops gradually 3-6 hours after ingestion, the drug is not prescribed for the relief of emergency conditions .; Use caution when consuming large amounts of caffeine-containing foods or beverages during treatment.