Hydrocortisone ophthalmic ointment 0.5% 3g elf
Condition: New product
1000 Items
Rating:
Be the first to write a review!
More info
Active ingredients
Hydrocortisone
Release form
Ointment
Composition
1 g ointment contains: Active ingredient: hydrocortisone acetate 5 mg.
Pharmacological effect
Pharmacological action - anti-inflammatory, anti-edematous, antiallergic, antipruritic. Inhibits phospholipase a2, disrupts pg synthesis, activation of tissue kinins, inhibits the migration of leukocytes and lymphocytes to the inflammatory focus.
Pharmacokinetics
Binding to plasma proteins - 40-90%. Metabolized mainly in the liver. T1 / 2 - 80-120 min. Excreted by the kidneys mainly in the form of metabolites.
Indications
Hydrocortisone ointment 1% is used for inflammatory and allergic skin diseases of non-microbial etiology: eczema, dermatitis (allergic, contact); diffuse neurodermatitis, pruritic dermatosis, photodermatosis, anogenital itching, insect bite, erythroderma, psoriasis.
Contraindications
Use of the drug is contraindicated in case of hypersensitivity to hydrocortisone or other components of the drug, bacterial, viral and fungal skin diseases, skin tuberculosis, syphilitic skin lesions. dermatitis, post-vaccination period, childish age (up to 2 years, with itching in the anus - up to 12 years).
Precautionary measures
Excessive and / or too frequent during the day use by adults or use in young children may be accompanied by absorption and development of the systemic action of the drug.
Use during pregnancy and lactation
In pregnancy, it is possible if the expected effect of therapy outweighs the potential risk to the fetus. With care and briefly when breastfeeding.
Dosage and administration
Outwardly. Ointment is applied with a thin layer to the affected skin 2-3 times a day. The duration of the course of treatment depends on the nature of the disease and the effectiveness of therapy, making, as a rule, 6-14 days; with persistent disease, it can be extended to 20 days. The dose of the drug, used for 1 week, should not exceed 30-60 g. When itching in the anus, before applying the drug, wash the affected area with warm water and soap, then water and dry the skin surface with a towel or napkin.Occlusive dressings can be used on limited foci to enhance the effect. When using the drug in children aged 2 years and older, the total duration of treatment should be limited and measures leading to increased resorption of steroid absorption (warming, fixing and occlusive dressings) should be excluded. In childhood suppression of the function adrenal cortex can develop faster. In addition, there may be a decrease in growth hormone excretion. When using the drug for a long time, you need to monitor body weight, height, plasma cortisol level.
Side effects
Individual intolerance in the form of hyperemia, swelling and itching may occur in places of application of the ointment. With prolonged use, it is also possible to develop secondary infections of the skin, atrophic changes in it, and hypertrichosis. To prevent infectious skin lesions, it is recommended to prescribe the drug in combination with antibacterial and antifungal agents. With prolonged use of an ointment or use of an occlusive dressing, especially in large areas of damage, hypercortisolism may develop as a manifestation of the resorptive action of hydrocortisone.
Overdose
Cases of overdose are not registered.
Interaction with other drugs
With simultaneous use of hydrocortisone increases the toxicity of cardiac glycosides (due to the resulting hypokalemia increases the risk of arrhythmias); with acetylsalicylic acid - accelerates its excretion and reduces its concentration in the blood plasma (with the withdrawal of hydrocortisone, the concentration of salicylates in the blood increases and the risk of side effects increases); with paracetamol - an increased risk of the development of the hepatotoxic effect of paracetamol (induction of hepatic enzymes and the formation of a toxic metabolite of paracetamol); with cyclosporine - increased side effects of hydrocortisone due to inhibition of its metabolism; with ketoconazole - increased side effects of hydrocortisone due to a decrease in its clearance. Hydrocortisone reduces the effectiveness of hypoglycemic agents; enhances the effect of indirect anticoagulants of coumarin derivatives. Hydrocortisone reduces the effect of vitamin D on the absorption of calcium ions in the intestinal lumen.Ergocalciferol and parathyroid hormone prevent the development of osteopathy caused by GCS. Hydrocortisone enhances the metabolism of isoniazid, meksiletin (especially in fast acetylators), which leads to a decrease in their plasma concentrations; increases (with long-term therapy) the content of folic acid; reduces the concentration of praziquantel in the blood. Hydrocortisone in high doses reduces the effect of somatropin. Hypokalemia caused by GCS may increase the severity and duration of muscle blockade against the background of muscle relaxants. Antacids reduce the absorption of GKS. In increase the risk of hypokalemia, drugs containing sodium ions - edema and increase in blood pressure. swelling, in combination with NSAIDs for the treatment of arthritis may reduce the dose of corticosteroids due to the summation of the therapeutic effect. Indomethacin, displacing the corticosteroids from association with albumin, increases the risk of its side effects. Amphotericin B and carbonic anhydrase inhibitors increase the risk of osteoporosis. rifampicin) due to an increase in the metabolic rate of these substances. Inhibitors of the function of the adrenal cortex (including mitotane) may necessitate an increase in the dose of GCS. The clearance of GCS rises against the background of prep Ratov zhelezy.Immunodepressanty thyroid hormones increase the risk of infections and lymphoma or other lymphoproliferative disorders associated with Epstein-Barr.Estrogeny (including oral contraceptives estrogensoderzhaschie) reduce clearance GCS extend T1 / 2 and their therapeutic and toxic effects. The emergence of hirsutism and acne contributes to the simultaneous use of other steroid hormonal agents - androgens, estrogens, anabolic steroids, oral contraceptives. Tricyclic antidepressants may increase the severity of depression caused by the use of GCS (not shown for the treatment of these side effects). GCS, antipsychotics (neuroleptics), carbutamide and azathioprine.Simultaneous administration with m-holinoblokatorami, as well as with agents that have m-holinoblokiruyuschim action (including antihistamines, tricyclic antidepressants), with nitrates increases intraocular pressure. viruses and the development of infections.
special instructions
Use with caution in parasitic and infectious diseases of viral, fungal or bacterial nature (currently or recently transferred, including recent contact with a patient) - herpes simplex, herpes zoster (viraemic phase), chicken pox, measles, amebiasis, strongyloidosis (established or suspect), systemic mycosis; active and latent tuberculosis. Use in severe infectious diseases is permissible only against the background of specific therapy. Use with caution for 8 weeks before and 2 weeks after vaccination, for lymphadenitis after BCG vaccination, for immunodeficiency states (including AIDS or HIV infection). With caution to be used for gastrointestinal diseases: gastric ulcer and duodenal ulcer, esophagitis, gastritis, acute or latent peptic ulcer, newly created intestinal anastomosis, nonspecific ulcerative colitis with the threat of perforation or abscess iting, diverticulitis. Use with caution in diseases of the cardiovascular system, including after a recent myocardial infarction (patients with acute and subacute myocardial infarction may spread necrosis, slow the formation of scar tissue and, as a result, rupture of the heart muscle), with decompensated chronic heart failure, hypertension, hyperlipidemia), with endocrine diseases - diabetes mellitus ( including violation of tolerance to carbohydrates), thyrotoxicosis, hypothyroidism, Itsenko-Cushing's disease, with severe chronic renal and / or liver failure, nephrourolithiasis, with hypoalbuminemia and conditions predisposing to its occurrence, with systemic osteoporosis, myasthenia, acute psychosis, obesity (III-IV degree), with poliomyelitis (except for the form of bulbar encephalitis),pregnancy, lactation. If intra-articular administration is necessary, use with caution in patients with a general serious condition, inefficiency (or short duration) of the action of 2 previous injections (taking into account the individual properties of GCS). When hydrocortisone is insufficient for 48-72 hours therapy, it is advisable to replace hydrocortisone with another glucocorticoid drug that does not cause sodium retention in the body. During treatment with hydrocortisone, it is recommended to prescribe a diet with sodium restriction and increased potassium content. The relative adrenal insufficiency caused by hydrocortisone may persist for several months after its withdrawal. Given this, in stressful situations that occur during the specified period, hormonal therapy is resumed with simultaneous administration of salts and / or mineralocorticoids. In patients with active tuberculosis, hydrocortisone should be used in combination with appropriate anti-tuberculosis therapy. In the case of latent tuberculosis or during tuberculin turn tests, the patient’s condition should be carefully monitored, and chemoprophylaxis should be carried out if necessary.