Leflobakt film-coated pills 500 mg N5
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Description
Leflobact Tablets is a synthetic broad spectrum antimicrobial bactericidal agent from the group of fluoroquinolones. It is prescribed for a number of infectious diseases caused by various pathogenic microorganisms. For example, chronic bronchitis, pneumonia, sinusitis and kidney disease. Leflobact is also used in the treatment of prostatitis, atheroma with the presence of pus in it, various types of boils, infections of the skin, urinary tract, as well as drug-resistant forms of tuberculosis.
Active ingredients
Levofloxacin
Release form
Pills
Composition
Levofloxacin hemihydrate, calcium stearate, 1500 starch, potato starch, Crospovidone Cal creepne, Povidone (126,4 ± 2700 CI), lactose monohydrate (milk sugar), talc, micro-crystallized, white, white, white, white, black, white, white, white, white, white, white, white, white, white, white, white. (polyethylene glycol 4000), titanium dioxide, tropeolin 0.
Pharmacological effect
Levofloxacin is a levorotatory isomer of ofloxacin. Levofloxacin blocks DNA gyrase enzymes (topoisomerase II) and topoisomerase IV, violates the supercoiling and stitching of DNA breaks, inhibits DNA synthesis, causes profound morphological changes in the cytoplasm, cell wall and bacterial membrane. It is active against most strains of microorganisms, both in vitro and in vivo.
Pharmacokinetics
Quickly and almost completely absorbed after ingestion, food intake has little effect on its absorption. Absolute bioavailability when administered is 99-100%. After a single dose of 500mg of levofloxacin, the maximum plasma concentration (Сmax) is reached within 1-2 hours and is 5.2 ± 1.2 mcg / ml. After ingestion, levofloxacin is relatively slowly excreted from blood plasma (elimination half-life (T1 / 2) - 6-8 h). Excretion, mainly through the kidneys (more than 85% of the dose). The total clearance of levofloxacin after a single dose of 500 mg was 175 ± 29.2 ml / min.
Indications
Levofloxacin-sensitive bacterial infections in adults: acute sinusitis, exacerbation of chronic bronchitis, community-acquired pneumonia, uncomplicated urinary tract infections, complications of urinary tract infections (including pyelonephritis), chronic bacterial prostatitis, infections of the skin and soft tissues, complex of the complex and soft tissue, for the complex and soft tissues, for the complex and soft tissues; resistant forms of tuberculosis, prevention and treatment of anthrax during airborne infection.
Contraindications
Hypersensitivity to levofloxacin, other fluoroquinolones or any other component of the drug, epilepsy, pseudo-paralytic myasthenia (myasthenia gravis), tendon lesions during previous treatment with quinolones, impaired kidney function (with KK less than 20 ml / min), with a quinolone treatment (impaired kidney function (with KK less than 20 ml / min), with a quinolone treatment, impaired renal function (with KK less than 20 ml / min), he is in the presence of a quinolone, impaired kidney function (with KK less than 20 ml / min), with a treatment with quinolones, impaired kidney function (hemorrhagia) lactose intolerance or glucose-galactose malabsorption.
Precautionary measures
With care: patients predisposed to the development of seizures, patients with deficiency of glucose-6-phosphate dehydrogenase, patients with impaired renal function, patients with diabetes receiving oral hypoglycemic drugs, for example, glibenclamide or insulin preparations, patients with psychosis or having anamnesis diseases.
Use during pregnancy and lactation
Contraindicated
Dosage and administration
To accept to food or in a break between meals, without chewing, washing down with enough liquid (from 0.5 to 1 glass). The drug should be taken at least 2 hours before or 2 hours after taking drugs containing magnesium and / or aluminum, iron, zinc, or sucralfate. If you accidentally miss the drug, you should take the next dose as soon as possible and then continue to take Leflobact according to the recommended dosage regimen. Acute sinusitis - 500 mg 1 time per day, for 10-14 days. Exacerbation of chronic bronchitis - 500mg 1 time per day, for 7-10 days. Community-acquired pneumonia - 500 mg 1-2 times a day, for 7-14 days. Uncomplicated urinary tract infections - 250 mg 1 time per day for 3 days. Complicated urinary tract infections - 500 mg 1 time per day, for 7-14 days. Pyelonephritis - 500 mg 1 time per day, for 7-10 days. Chronic bacterial prostatitis - 500 mg 1 time per day, for 28 days. Infections of the skin and soft tissues - 500 mg 1-2 times a day, for 7-14 days. Comprehensive treatment of drug-resistant forms of tuberculosis - 500 mg 1-2 times a day - up to 3 months. Prevention and treatment of anthrax in the airborne route of infection - 500 mg 1 time per day - up to 8 weeks.
Side effects
Headache, dizziness, diarrhea, vomiting, nausea, increased activity of "liver" enzymes in the blood (such as alanine aminotransferase (ALT), aspartate aminotransferase (AST)), elevated alkaline phosphatase (ALP) and gamma-glutamyl transferase (GGT), and insomnia.
Overdose
Symptoms: nausea, erosive lesions of the mucous membranes of the gastrointestinal tract (GIT), prolonged QT interval, confusion, dizziness, convulsions. Treatment: gastric lavage, symptomatic, dialysis is ineffective. There is no specific antidote.
Interaction with other drugs
Preparations containing divalent or trivalent cations, such as zinc or iron salts (preparations for treating anemia), magnesium- and / or aluminum-containing preparations (such as antacids), didanosine (only dosage forms containing aluminum or magnesium as a buffer) It is recommended to take at least 2 hours before or 2 hours after taking Leflobact pills. The action of the drug Leflobact is significantly weakened with simultaneous use of sucralfate (means for protecting the gastric mucosa). Patients receiving levofloxacin and sucralfate are advised to take sucralfate 2 hours after taking levofloxacin. With the simultaneous use of quinolones and theophylline, nonsteroidal anti-inflammatory drugs and other drugs that reduce the threshold of convulsive readiness of the brain, a pronounced decrease in the threshold of convulsive readiness of the brain is possible. In patients treated with levofloxacin in combination with indirect anticoagulants (for example, warfarin), an increase in prothrombin time / international normalized ratio and / or development of bleeding, including severe, was observed. Therefore, with the simultaneous use of indirect anticoagulants and levofloxacin, regular monitoring of blood coagulation parameters is necessary. Simultaneous intake of glucocorticosteroids increases the risk of tendon rupture. Levofloxacin, like other fluoroquinolones, should be used with caution in patients receiving drugs that prolong the QT interval (for example, class IA and III antiarrhythmic drugs, tricyclic antidepressants, macrolides, antipsychotics).
special instructions
May reduce psychomotor reactions and ability to concentrate. This may represent a certain risk in situations where these abilities are of particular importance (for example, when driving a car, when servicing machines and mechanisms, when working in an unstable position).